Children's Brain Tumor Network (original) (raw)

Accelerating childhood brain tumor research to faster cures

Over 30 types of pediatric brain and spinal cord tumor clinical and molecular data, biospecimens, and cell-lines are available at no cost to academic researchers. Our open science model has shortened research time by up
to 20 years.

By working together to collect and share resources, we can save more children.

CBTN by the Numbers

Brain and CNS tumors are the most common cause of disease related death in children aged 0–19 years in the U.S. and across the globe, with approximately 412,000 children and young adults living with a brain tumor each year.

SpecimenOngoingGene Expression Analysis Platform Evaluation for FFPE Specimen Material-Based Studies…Newly developed technology is advancing the ability of researchers to gain important insight from small clinical specimens.…Medulloblastoma, HGG…Mateusz KoptyraChildren’s Hospital of PhiladelphiaPhiladelphia, PA, USADataSpecimenOngoingProteogenomic Identification of Structural Variations…Changes to DNA that can give rise to cancers often create fusion proteins, proteins that may be useful as therapeutic targets. Using data from the Pediatric Brain Tumor Atlas, researchers will analyze for the presence of such proteins in an effort to advance treatment options for pediatric brain cancers.…Medulloblastoma, DIPG…Brian RoodChildren’s National HospitalWashington, DC, USADataOngoingDeciphering the Molecular Characteristics of Pediatric Meningiomas…Pediatric meningiomas are extremely rare tumors and are often of an aggressive form unresponsive to available treatments. Specimens from the Pediatric Brain Tumor Atlas will allow researchers to study this rare tumor in an effort to develop targeted therapies.…Medulloblastoma, HGG, LGG, Ependymoma, Meningioma, Schwannoma…Nadia DahmaneWeill Cornell MedicineNew York, NY, USA

Cavatica…Cavatica is a cloud-based portal environment developed to securely store, share and analyze large volumes of pediatric brain tumor genomic data and is the largest, clinically-annotated pediatric database in the world. Named for the popular children’s story Charlotte’s Web, Cavatica allows researchers and investigators to access and share a network of data, pipelines, algorithms, visualizations, and hypotheses’ about specific types of tumors. Cavatica includes data from a number of sources including the Children’s Brain Tumor Tissue Consortium (CBTN), Pacific Neuro-Oncology Consortium (PNOC), Stand Up to Cancer, TARGET and TCGA.…