kalyan hazra | Central Council for Research in Ayurvedic Sciences (original) (raw)
Papers by kalyan hazra
Indian Journal of Traditional Knowledge
Indian Journal of Natural Products and Resources
Uses of Abroma augusta L. stem and root are mentioned in traditional texts where the presence of ... more Uses of Abroma augusta L. stem and root are mentioned in traditional texts where the presence of the alkaloid, betaine in these parts is known. The study was undertaken to generate a pharmacognostical and phytochemical blueprint of Abroma augusta stem bark and detection of the bioactive alkaloid, betaine in it. Authenticated plant materials were subjected to pharmacognostical, physicochemical, and phytochemical studies. HPTLC, HPLC, and FTIR were used for chemical fingerprinting of the plant materials. Diagnostic features of A. augusta stem bark such as organoleptic evaluation, powder microscopic characters, fluorescence profile with various reagents were established. Phytochemical screening of different solvent extracts showed the presence of alkaloids, steroids, saponins, tannins, phenolics, glycosides, but fewer terpenoids, flavonoids, and carbohydrates. This was rationalized by FTIR spectroscopy of the chloroform extract that gave maximum extractive yield. HPTLC and HPLC fingerprint profiling with marker identification was generated. The alkaloid, betaine was isolated and identified by mass spectrum. The botanical and chemical screening suggested that A. augusta stem bark may be a potential substitute for the root or stem of the plant. However, further, bio-evaluations are required to ascertain its possible clinical applications. The generated profile may serve as a reference document in future for identification and authentication of the plant material.
The plant Acacia catechu, commonly known as the cutch tree is a tropically abundant plant which i... more The plant Acacia catechu, commonly known as the cutch tree is a tropically abundant plant which is widely used in Indian subcontinent with some presence in Central Asia and in China. The species has lent its name to important catechins, catechols. The most used part of this plant is stem or heartwood as water extract. Some pharmacological demonstrations have also been done with ethyl acetate extract. Leaves of the plant found some primary applications in biological actions. Presence of several polyphenolic compounds like tannins, flavonoids are responsible for many biological activities. The ethno pharmacological values of the plant make it a potent therapeutic and cosmetic agent. In the present review, comprehensive information on pharmacognostic evaluation, botanical aspects, therapeutic values, modern pharmacological activities and chemical constituents along with their 1 H NMR data are provided to explore the potential and to advance research.
The objective of this research work was to formulate and evaluate the tablets of Tenatoprazole. T... more The objective of this research work was to formulate and evaluate the tablets of Tenatoprazole. The tablets were prepared by direct compression method. The formulations P-I to P-III were optimized by incorporating varying composition of excipients. The different excipients were tested for their compatibility with drug, and revealed that there was no chemical and physical interaction occurred. The thickness, hardness, friability, weight variation and disintegration time were evaluated. The effect of these variables on the drug release profile of drug was also studied. The in-vitro drug releases studied were performed in the USP Apparatus-II (Paddle) at 50 rpm speed and temperature of 37°C ± 2°C. Based on the result P-III formulation was selected as the best formulation. The In-vitro drug release profiles of formulations were found to be optimum.
International Journal of Herbal Medicine, 2019
The plant Euphorbia hirta L. belongs to family Euphorbiaceae. This plant is known for medicinal p... more The plant Euphorbia hirta L. belongs to family Euphorbiaceae. This plant is known for medicinal properties, such as in anti-oxidant, diarrhea, dysentery, anti-tumor, anti-bacterial etc. The present study considers the detail investigation of macroscopy, microscopy, preliminary qualititative phytochemical analysis, physicochemical evaluations, chromatography and infra red spectroscopy profiling. Microscopical investigation was adopted to identify the powder characters of whole plant include multi cellular hirsute covering trichomes, epidermal cells with sinuous wall, anomocytic stomata, spiral and retulate xylem vessels, laticiferous ducts, anther sac with pollen grains etc. Physicochemical parameters reveal the data of quality, purity while phytochemical screening reflects the presence of various secondary metabolites. Data from botanical and chemical screening in combination may be considered for further pharmacological and therapeutical evaluation of the species and will assist in...
The present study aimed to generate the qualitative, quantitative parameters for seeds of Argemon... more The present study aimed to generate the qualitative, quantitative parameters for seeds of Argemone mexicana L. (Family: Papaveraceae) through phyto-pharmacognostical, physicochemical, phytochemical studies. Qualitative chromatographic profiling has been generated. Spectral pattern of the extract by infra-red spectroscopy has also been studied. The pharmacognostical evaluation showed useful characters for the standardization of Argemone mexicana seed. Transverse section showed presence of lignified, non-lignified fibers, scalariform vessels and oil globules in mesocarp region. Lignified stone cells, endosperm and endocarp are observed in powder microscopy. Physicochemical studies of fruit powder shows, total ash (8.79%), and acid insoluble ash (3.16%). Highest extractive value (36.34%) obtained from acetone. Phytochemical analysis revealed the presence several secondary metabolites. Chromatographic profiling done through planar and column and spectral pattern obtained through infra-red. The generated data set by botanical and chemical screening in combination may be considered as a standard for authentication and identification and may be referred in standardisation and monograph preparation.
The plant Euphorbia hirta L. belongs to family Euphorbiaceae. This plant is known for medicinal p... more The plant Euphorbia hirta L. belongs to family Euphorbiaceae. This plant is known for medicinal properties, such as in anti-oxidant, diarrhea, dysentery, anti-tumor, anti-bacterial etc. The present study considers the detail investigation of macroscopy, microscopy, preliminary qualititative phytochemical analysis, physicochemical evaluations, chromatography and infra red spectroscopy profiling. Microscopical investigation was adopted to identify the powder characters of whole plant include multi cellular hirsute covering trichomes, epidermal cells with sinuous wall, anomocytic stomata, spiral and retulate xylem vessels, laticiferous ducts, anther sac with pollen grains etc. Physicochemical parameters reveal the data of quality, purity while phytochemical screening reflects the presence of various secondary metabolites. Data from botanical and chemical screening in combination may be considered for further pharmacological and therapeutical evaluation of the species and will assist in standardization for quality, purity and sample identification.
Indian Journal of Traditional Knowledge
Indian Journal of Natural Products and Resources
Uses of Abroma augusta L. stem and root are mentioned in traditional texts where the presence of ... more Uses of Abroma augusta L. stem and root are mentioned in traditional texts where the presence of the alkaloid, betaine in these parts is known. The study was undertaken to generate a pharmacognostical and phytochemical blueprint of Abroma augusta stem bark and detection of the bioactive alkaloid, betaine in it. Authenticated plant materials were subjected to pharmacognostical, physicochemical, and phytochemical studies. HPTLC, HPLC, and FTIR were used for chemical fingerprinting of the plant materials. Diagnostic features of A. augusta stem bark such as organoleptic evaluation, powder microscopic characters, fluorescence profile with various reagents were established. Phytochemical screening of different solvent extracts showed the presence of alkaloids, steroids, saponins, tannins, phenolics, glycosides, but fewer terpenoids, flavonoids, and carbohydrates. This was rationalized by FTIR spectroscopy of the chloroform extract that gave maximum extractive yield. HPTLC and HPLC fingerprint profiling with marker identification was generated. The alkaloid, betaine was isolated and identified by mass spectrum. The botanical and chemical screening suggested that A. augusta stem bark may be a potential substitute for the root or stem of the plant. However, further, bio-evaluations are required to ascertain its possible clinical applications. The generated profile may serve as a reference document in future for identification and authentication of the plant material.
The plant Acacia catechu, commonly known as the cutch tree is a tropically abundant plant which i... more The plant Acacia catechu, commonly known as the cutch tree is a tropically abundant plant which is widely used in Indian subcontinent with some presence in Central Asia and in China. The species has lent its name to important catechins, catechols. The most used part of this plant is stem or heartwood as water extract. Some pharmacological demonstrations have also been done with ethyl acetate extract. Leaves of the plant found some primary applications in biological actions. Presence of several polyphenolic compounds like tannins, flavonoids are responsible for many biological activities. The ethno pharmacological values of the plant make it a potent therapeutic and cosmetic agent. In the present review, comprehensive information on pharmacognostic evaluation, botanical aspects, therapeutic values, modern pharmacological activities and chemical constituents along with their 1 H NMR data are provided to explore the potential and to advance research.
The objective of this research work was to formulate and evaluate the tablets of Tenatoprazole. T... more The objective of this research work was to formulate and evaluate the tablets of Tenatoprazole. The tablets were prepared by direct compression method. The formulations P-I to P-III were optimized by incorporating varying composition of excipients. The different excipients were tested for their compatibility with drug, and revealed that there was no chemical and physical interaction occurred. The thickness, hardness, friability, weight variation and disintegration time were evaluated. The effect of these variables on the drug release profile of drug was also studied. The in-vitro drug releases studied were performed in the USP Apparatus-II (Paddle) at 50 rpm speed and temperature of 37°C ± 2°C. Based on the result P-III formulation was selected as the best formulation. The In-vitro drug release profiles of formulations were found to be optimum.
International Journal of Herbal Medicine, 2019
The plant Euphorbia hirta L. belongs to family Euphorbiaceae. This plant is known for medicinal p... more The plant Euphorbia hirta L. belongs to family Euphorbiaceae. This plant is known for medicinal properties, such as in anti-oxidant, diarrhea, dysentery, anti-tumor, anti-bacterial etc. The present study considers the detail investigation of macroscopy, microscopy, preliminary qualititative phytochemical analysis, physicochemical evaluations, chromatography and infra red spectroscopy profiling. Microscopical investigation was adopted to identify the powder characters of whole plant include multi cellular hirsute covering trichomes, epidermal cells with sinuous wall, anomocytic stomata, spiral and retulate xylem vessels, laticiferous ducts, anther sac with pollen grains etc. Physicochemical parameters reveal the data of quality, purity while phytochemical screening reflects the presence of various secondary metabolites. Data from botanical and chemical screening in combination may be considered for further pharmacological and therapeutical evaluation of the species and will assist in...
The present study aimed to generate the qualitative, quantitative parameters for seeds of Argemon... more The present study aimed to generate the qualitative, quantitative parameters for seeds of Argemone mexicana L. (Family: Papaveraceae) through phyto-pharmacognostical, physicochemical, phytochemical studies. Qualitative chromatographic profiling has been generated. Spectral pattern of the extract by infra-red spectroscopy has also been studied. The pharmacognostical evaluation showed useful characters for the standardization of Argemone mexicana seed. Transverse section showed presence of lignified, non-lignified fibers, scalariform vessels and oil globules in mesocarp region. Lignified stone cells, endosperm and endocarp are observed in powder microscopy. Physicochemical studies of fruit powder shows, total ash (8.79%), and acid insoluble ash (3.16%). Highest extractive value (36.34%) obtained from acetone. Phytochemical analysis revealed the presence several secondary metabolites. Chromatographic profiling done through planar and column and spectral pattern obtained through infra-red. The generated data set by botanical and chemical screening in combination may be considered as a standard for authentication and identification and may be referred in standardisation and monograph preparation.
The plant Euphorbia hirta L. belongs to family Euphorbiaceae. This plant is known for medicinal p... more The plant Euphorbia hirta L. belongs to family Euphorbiaceae. This plant is known for medicinal properties, such as in anti-oxidant, diarrhea, dysentery, anti-tumor, anti-bacterial etc. The present study considers the detail investigation of macroscopy, microscopy, preliminary qualititative phytochemical analysis, physicochemical evaluations, chromatography and infra red spectroscopy profiling. Microscopical investigation was adopted to identify the powder characters of whole plant include multi cellular hirsute covering trichomes, epidermal cells with sinuous wall, anomocytic stomata, spiral and retulate xylem vessels, laticiferous ducts, anther sac with pollen grains etc. Physicochemical parameters reveal the data of quality, purity while phytochemical screening reflects the presence of various secondary metabolites. Data from botanical and chemical screening in combination may be considered for further pharmacological and therapeutical evaluation of the species and will assist in standardization for quality, purity and sample identification.