Yacine Boumghar - Academia.edu (original) (raw)

Papers by Yacine Boumghar

Lebensmittel-Wissenschaft & Technologie, Jul 1, 2018

Abstract Industrial vegetable wastes contain high amounts of valuable molecules and constitute a ... more Abstract Industrial vegetable wastes contain high amounts of valuable molecules and constitute a valuable source of bioactive compounds providing health benefits. Spinach (Spinacia oleracea), a green leafy vegetable, is known to its valuable phytochemical's content. However, its production yields about 25% of wastes that can be valorized for the production of value-added food supplements. This work focuses on the development and optimization of sustainable extraction using supercritical CO2 (SC-CO2) of the lutein and chlorophyll, two health functional molecules, from spinach by-products. Box–Behnken experimental design was used to optimize the process variables: pressure (10, 30, 50 MPa), co-solvent percentages (0, 5, and 10% (v/v), temperature (40, 50, 60 °C), time (1, 3, 5 h). It was found that the optimum extraction parameters were at temperature of 56 °C, extraction time of 3.6 h, pressure of 39 MPa, and 10% ethanol as cosolvent. Under these conditions, a yield of 72% lutein and 50% of chlorophyll was obtained.

Industrial Crops and Products, Aug 1, 2022

Processes

Research on cannabis oil has evolved to encompass the pharmaceutical industry for the therapeutic... more Research on cannabis oil has evolved to encompass the pharmaceutical industry for the therapeutic potential of the active compounds for pathologies such as Alzheimer, auto-immune disorders, and cancer. These debilitating diseases are best treated with cannabinoids such as tetrahydrocannabinol (∆9-THC), cannabigerol (CBG), and cannabinol (CBN), which relieve neuropathic pain and stimulate the immune system. We extracted cannabinoids from plants with supercritical CO2 and produced an extract with a total yield close to 26%. The three-level Box–Behnken experimental design considered four factors: Temperature, pressure, CO2 flow rate, and processing time, with predetermined parameters at low, medium, and high levels. The mathematical model was evaluated by regression analysis. The yield of ∆9-THC and CBG reached a maximum after 2 h and 15 g/min of CO2, 235 bar, 55 °C (64.3 g THC/100 g of raw material and 4.6 g CBG/100 g of raw material). After another 2 h of extraction time, the yield o...

Molecules

The chemical compositions of eleven wild species of aromatic and medicinal plants indigenous to A... more The chemical compositions of eleven wild species of aromatic and medicinal plants indigenous to Algeria, including Thymus, Mentha, Rosmarinus, Lavandula, and Eucalyptus, were analyzed. The identification of the chemical composition of each oil was conducted using GC-FID and GC-MS capillary gas chromatography. The study investigated the chemical variability of the essential oils based on several parameters. These included the impact of the vegetative cycle on oil composition, variations among subspecies of the same species, variations among species within the same genus, the influence of environmental factors on composition variations within a species, chemo typing, and the genetic factors (such as hybridization) contributing to chemical variability. The concepts of chemotaxonomy, chemotype, and chemical markers were examined to understand their limitations and emphasize the importance of regulating the use of essential oils derived from wild plants. The study advocates for an approa...

The Canadian Journal of Chemical Engineering

Industrial Crops and Products

Industrial Biotechnology, 2019

Yellow birch barks is one of the abundant species in Quebec with harvest surplus in several regio... more Yellow birch barks is one of the abundant species in Quebec with harvest surplus in several regions. Biofuels or biochemicals such as biobutanol can be produced using the surplus feedstock, however challenges such as the cost of pretreatment, production of unwanted by-products in the fermentation process, and the efficient recovery of solvents must be addressed to make it feasible. The objectives of this study are to establish the optimal conditions to produce biobutanol from Eastern Canadian yellow birch; to identify natural/local Clostridium sp. strains that are capable of producing Isopropanol-Butanol-Ethanol (IBE) from synthetic sugar mixtures, as candidates for metabolic engineering and to benchmark solvent producing ability with commercially available strains; and to elucidate the challenges of paradigm shift to IBE production. Alkali pretreatment of the biomass using chemical that are present in the Kraft process were performed, followed by enzymatic hydrolysis to obtain fermentable sugars and subsequent fermentation with Clostridium acetobutylicum DSM 792. The results showed that the produced Acetone-Butanol-Ethanol (ABE) solvent concentration were 6.6-8.2 g/L of acetone; 11.2-13.1 g/L of butanol; and 2.5-2.7 g/L of ethanol. The organic acids concentration was acetic acid, 1.1-1.8 g/L, and butyric acid, 0.1-0.2 g/L. Further fermentation experiments to benchmark IBE were performed using both Clostridium beijerinckii DSM 6423 and wild isolated strains, which revealed the gaps in terms of yields and the need to optimize the fermentation paradigm. Moreover, alternative process sequences for product recovery were identified, and the impact of prior liquid-liquid extraction elucidated.

Biology, 2020

Armillaria sinapina, a fungal pathogen of primary timber species of North American forests, cause... more Armillaria sinapina, a fungal pathogen of primary timber species of North American forests, causes white root rot disease that ultimately kills the trees. A more detailed understanding of the molecular mechanisms underlying this illness will support future developments on disease resistance and management, as well as in the decomposition of cellulosic material for further use. In this study, RNA-Seq technology was used to compare the transcriptome profiles of A. sinapina fungal culture grown in yeast malt broth medium supplemented or not with betulin, a natural compound of the terpenoid group found in abundance in white birch bark. This was done to identify enzyme transcripts involved in the metabolism (redox reaction) of betulin into betulinic acid, a potent anticancer drug. De novo assembly and characterization of A. sinapina transcriptome was performed using Illumina technology. A total of 170,592,464 reads were generated, then 273,561 transcripts were characterized. Approximatel...

Industrial Green Chemistry, 2020

Chemical composition and herbicidal, antifungal, antibacterial and molluscicidal activities of es... more Chemical composition and herbicidal, antifungal, antibacterial and molluscicidal activities of essential oils from Choukzerk, Eryngium triquetrum, and Alexander, Smyrnium olusatrum, from western Algeria were characterized. Capillary GC-FID and GC/MS were used to investigate chemical composition of both essential oils, and the antifungal, antibacterial, molluscicidal and herbicidal activities were determined by % inhibition. Collective essential oil of E. triquetrum was dominated by falcarinol (74.8%) and octane (5.6%). The collective essential oil of S. olusatrum was dominated by furanoeremophilone (31.5%), furanodiene+curzurene (19.3%) and (E)-β-caryophyllene (11%). The E. triquetrum oil was tested and a pure falcarinol (99%) showed virtuous herbicidal and antibacterial activities against potato blackleg disease, Pectobacterium atrosepticum, and Gram-negative soil bacterium, Pseudomonas cichorii (85 and 100% inhibition, respectively), and high ecotoxic activity against brine shrimp...

International Journal of Molecular Sciences

Chaga (Inonotus obliquus) is a medicinal fungus used in traditional medicine of Native American a... more Chaga (Inonotus obliquus) is a medicinal fungus used in traditional medicine of Native American and North Eurasian cultures. Several studies have demonstrated the medicinal properties of chaga’s bioactive molecules. For example, several terpenoids (e.g., betulin, betulinic acid and inotodiol) isolated from I. obliquus cells have proven effectiveness in treating different types of tumor cells. However, the molecular mechanisms and regulation underlying the biosynthesis of chaga terpenoids remain unknown. In this study, we report on the optimization of growing conditions for cultured I. obliquus in presence of different betulin sources (e.g., betulin or white birch bark). It was found that better results were obtained for a liquid culture pH 6.2 at 28 °C. In addition, a de novo assembly and characterization of I. obliquus transcriptome in these growth conditions using Illumina technology was performed. A total of 219,288,500 clean reads were generated, allowing for the identification ...

Molecules (Basel, Switzerland), Jan 10, 2018

Lignin availability has increased significantly due to the commercialization of several processes... more Lignin availability has increased significantly due to the commercialization of several processes for recovery and further development of alternatives for integration into Kraft pulp mills. Also, progress in lignin characterization, understanding of its chemistry as well as processing methods have resulted in the identification of novel lignin-based products and potential derivatives, which can serve as building block chemicals. However, all these have not led to the successful commercialization of lignin-based chemicals and materials. This is because most analyses and characterizations focus only on the technical suitability and quantify only the composition, functional groups present, size and morphology. Optical properties, such as the colour, which influences the uptake by users for diverse applications, are neither taken into consideration nor analysed. This paper investigates the quantification of lignin optical properties and how they can be influenced by process operating co...

Handbook of Industrial Drying, Fourth Edition, 2014

Journal of Supercritical Fluids, 2006

In the pharmaceutical area, fine particles with a narrow particle size distribution are required ... more In the pharmaceutical area, fine particles with a narrow particle size distribution are required to obtain a high surface area. In addition, particle size is one of the critical factors for the determination of appropriate routes of drug administration. In this work, we have used dense-gas anti-solvent crystallization techniques for the straightforward production of micron-sized powders of the chitosan derivatives d-Glucosamine Hydrochloride and d-Glucosamine Sulphate salts, which have increasing interest at present in medicinal research. The use of these crystallization methods permit to avoid the problematic communition and homogenization down-stream processes steps required after conventional crystallization methods. Semicontinuous ASES and batch GAS procedures, which are the two extremes of dense gas anti-solvent precipitation techniques, were successfully used for the micronization of these salts, and the results obtained with both procedures are compared and analysed.