Florestan Ogheard | CETIAT - Academia.edu (original) (raw)

Papers by Florestan Ogheard

Proceedings of the 19th International Flow Measurement Conference 2022 on Flow Measurement - FLOMEKO 2022

CERN European Organization for Nuclear Research - Zenodo, Sep 19, 2022

This report was written as part of activity A 1.1.2 from the EMPIR Establishing Metrology Standar... more This report was written as part of activity A 1.1.2 from the EMPIR Establishing Metrology Standards in Microfluidic Devices (MFMET) project. The three-year European project commenced on 1 st June 2021 and focused on providing a generic methodology of accurate measurement of a particular quantity in a microfluidic device by utilising standardised methods and reference documents, e.g. VIM & GUM. For more details about this project, please visit www.mfmet.eu The help from the members of the Microfluidics Association (www.microfluidics-association.org) is greatly acknowledged.

CERN European Organization for Nuclear Research - Zenodo, Sep 19, 2022

CERN European Organization for Nuclear Research - Zenodo, Feb 4, 2022

This report was written as part of activity A1.3.5 from the EMPIR Metrology for Drug Delivery (Me... more This report was written as part of activity A1.3.5 from the EMPIR Metrology for Drug Delivery (MeDD II) project. The three-year European project commenced on 1 st June 2019 and focused on providing traceable measurements of volume, flow and pressure of existing drug delivery devices and mixing behaviour and occlusion phenomena in multi-infusion systems. For more details about this project, please visit www.drugmetrology.com

Biomedical Engineering / Biomedizinische Technik

Objectives Microflow measurement devices are used in several science and health applications, mai... more Objectives Microflow measurement devices are used in several science and health applications, mainly drug delivery. In the last decade, several new methods based on optical technology were developed, namely the front tracking and interferometric method, in which the knowledge of the inner diameter of the syringe or the capillary used is critical. Only a few National Metrology Institutes (NMIs) can perform inner diameter measurements below 1 mm, which requires expensive technology. Therefore, IPQ, in cooperation with CETIAT, CMI and UNIDEMI, under the EMPIR project 18HLT08 MeDDII – Metrology for Drug Delivery, developed new measurement methods for small inner diameter tubes based on the gravimetric principle and optical methods in order to simplify the apparatus used for this type of measurements without increasing uncertainty. Methods The gravimetric experimental setup consists of measuring the liquid volume on a specific length of the glass tube. The optical method used is based on...

BioBiomedical Engineering / Biomedizinische Technik, 2022

Objectives: Microflow measurement devices are used in several science and health applications, ma... more Objectives: Microflow measurement devices are used in
several science and health applications, mainly drug delivery. In the last decade, several new methods based on
optical technology were developed, namely the front
tracking and interferometric method, in which the knowledge of the inner diameter of the syringe or the capillary
used is critical. Only a few National Metrology Institutes
(NMIs) can perform inner diameter measurements below 1
mm, which requires expensive technology. Therefore, IPQ,
in cooperation with CETIAT, CMI and UNIDEMI, under the
EMPIR project 18HLT08 MeDDII – Metrology for Drug Delivery, developed new measurement methods for small
inner diameter tubes based on the gravimetric principle
and optical methods in order to simplify the apparatus
used for this type of measurements without increasing
uncertainty.
Methods: The gravimetric experimental setup consists of
measuring the liquid volume on a specific length of the
glass tube. The optical method used is based on the front
track principle that uses a high-resolution camera and
ImageJ software, to determine the diameter at both ends of
each capillary.
Results: To validate the developed methods, a comparison was performed between CETIAT, CMI and IPQ and the
results obtained were all consistent.

Biomedical Engineering / Biomedizinische Technik

Improving the accuracy and enabling traceable measurements of volume, flow, and pressure in exist... more Improving the accuracy and enabling traceable measurements of volume, flow, and pressure in existing drug delivery devices and in-line sensors operating at very low flow rates is essential in several fields of activities and specially in medical applications. This can only be achieved through the development of new calibrationmethods and by expanding the existing metrological infrastructure to perform micro-flow and nano-flow measurements. In this paper, we will investigate new traceable techniques for measuring flow rate, from 5 nL/min to 1,500 nL/min and present the results of an inter-comparison between nine laboratories for the calibration of two different flow meters and a syringe pump.

La méthode de mesure de référence du débit d’émission de sources neutroniques se fonde sur la tec... more La méthode de mesure de référence du débit d’émission de sources neutroniques se fonde sur la technique du bain de manganèse. Elle est destinée à étalonner des sources de neutrons utilisant des radionucléides (241AmBe, 239PuBe, 252Cf,…) en termes de débit d’émission neutronique sous 4π sr. Ce dispositif est complété par un banc de mesure de l’anisotropie d’émission utilisant un support rotatif et un compteur long de type BF3. La source à mesurer est immergée dans une solution de sulfate de manganèse et les neutrons émis sont capturés par les constituants du bain. Dans une configuration classique (sphère de bain de manganèse de 1 m de diamètre et solution concentrée), environ la moitié de ces neutrons conduisent à la création de 56Mn par réaction (n, γ) sur 55Mn. Le radionucléide 56Mn a une période radioactive d’environ 2,6 heures et le bain de manganèse atteint son activité de saturation en 56Mn quand le nombre d’atomes radioactifs créés par unité de temps devient égal au nombre d’a...

Microflow measurement devices are used in several science and health applications, mainly drug de... more Microflow measurement devices are used in several science and health applications, mainly drug delivery. In the last decade, several new methods based on optical technology were developed, namely the front tracking and interferometric method, in which the knowledge of the inner diameter of the syringe or the capillary used is critical. There are only a very few National Metrology Institutes (NMIs) that can perform diameter measurements below 10 mm, which needs very expensive technology. Therefore, the Volume and Flow Laboratory (LVC) of the Portuguese Institute for Quality (IPQ), in cooperation with CETIAT, CMI and the Department of Mechanical and Industrial Engineering (DEMI) of The New University of Lisbon, under the EMPIR project MeDDII, developed new measurement methods for small inner diameters tubes based on the gravimetric principle and optical methods. The gravimetric experimental setup consists of measuring the liquid volume on a specific length of the glass tube. Knowing t...

This report was written as part of activity 2.1.1 from the EMPIR Establishing Metrology Standards... more This report was written as part of activity 2.1.1 from the EMPIR Establishing Metrology Standards in Microfluidic Devices (MFMET) project. The three-year European project commenced on 1^st June 2021 and focused on providing a generic methodology of accurate measurement of a particular quantity in a microfluidic device by utilising standardised methods and reference documents, e.g. VIM & GUM. For more details about this project, please visit www.mfmet.eu The document provides a description of a generic methodology of accurate measurement of a quantity by utilizing standardized methods and reference documents, e.g. VIM (International Vocabulary of Metrology) & GUM (Evaluation of measurement data – Guide to the expression of uncertainty in measurement).

This document presents the scientific and technical objectives, state of the art and expected pro... more This document presents the scientific and technical objectives, state of the art and expected progress beyond it, and most importantly the expected impact on metrology, science, standards, and society of the new joint research project - MeDD II, Metrology for drug delivery (follow up of project MeDD I). It was selected for funding through the EURAMET EMPIR program of the European Commission and the participating countries. The project starts in June 2019 and will last for three years. It involves 15 partners from National and Designated Metrology Institutes, companies, and academia. The main objective is to enable traceable measurements of volume, flow and pressure of existing drug delivery devices (for example infusion pumps and analysers) and inline sensors that work at flow rates lower than 100 nL/min, in order to prevent inaccurate measurement results. This project will also investigate fast changing flow rates, liquid mixing behaviour and occlusion phenomena in multi-infusion s...

Flow Measurement and Instrumentation, 2022

Mesures physiques, 2020

Cet article traite de la mesure et du controle de niveau de liquides dans un contexte industriel.... more Cet article traite de la mesure et du controle de niveau de liquides dans un contexte industriel. Les differents chapitres decrivent les differents principes de mesure et technologies presentes sur le marche, en exposant pour chacun le processus de mesure et ses variantes, les bonnes pratiques de mise en œuvre, les avantages et inconvenients de la technologie, les parametres d'influence de l'exactitude de mesure, les regles pratiques et, le cas echeant, legales. Les differentes technologies exposees - a visualisation directe de fluides, a flotteur ou plongeur, par mesure de pression, par dissipation thermique - permettent de repondre a la totalite des problematiques industrielles en selectionnant la solution la plus adaptee au besoin.

Overall Objective: Using input from A1.2.1-A1.2.4, CETIAT, NEL, IPQ, CMI, RISE, METAS and THL wil... more Overall Objective: Using input from A1.2.1-A1.2.4, CETIAT, NEL, IPQ, CMI, RISE, METAS and THL will write a report on calibration methods for measuring the response or delay time of drug delivery devices using Newtonian liquids for flow rates from 5 nL/min to 100 nL/min.<br> Once agreed by the consortium, the coordinator will then submit the report to EURAMET as D1: 'Report on calibration methods for measuring the response or delay time of drug delivery devices using Newtonian liquids for flow rates from 5 nL/min to 100 nL/min'.

19th International Congress of Metrology (CIM2019), 2019

According to its mission of national reference laboratory, LNE-CETIAT maintains and develops the ... more According to its mission of national reference laboratory, LNE-CETIAT maintains and develops the French standard for liquid water flow meters calibration from 1g.h-1 to 36 t.h-1. The reference calibration facilities at LNE-CETIAT are historically based on the flying start and stop gravimetric method. Because of the specificity of micro-flow rates, two separated and dedicated calibration benches are used for flow rates from 1 g.h-1 to 10 kg.h-1 on one side, and from 8 kg.h-1 to 36 t.h-1 on the other side. Continuous improvement of the calibration capabilities pushes LNE-CETIAT to upgrade the existing methods toward a dynamic measurement of the reference flow rate, in the scope of EURAMET EMPIR "METROWAMET" JRP in which CETIAT is a partner of the consortium. After a short review of the state of the art and a description of the current LNE-CETIAT's, this paper will first present the development of a dynamic liquid flow generator required to ensure the measurand's repr...

Cet article traite des differentes methodes d'etalonnage et de verification de debitmetres et... more Cet article traite des differentes methodes d'etalonnage et de verification de debitmetres et compteurs de liquide. Les principes de mesure, modeles de mesure des grandeurs de reference et incertitudes associees sont presentes pour chaque methode. Un bilan d'incertitudes d'etalonnage est presente a titre d'exemple pour les methodes gravimetriques, volumetriques et par comparaison a un debitmetre etalon. Les bonnes pratiques, parametres d'influence et l'expression des resultats d'etalonnage et de leurs incertitudes associees, necessaire a la bonne mise en œuvre des etalonnages en debitmetrie liquide, sont egalement abordes.

Proceedings of the 19th International Flow Measurement Conference 2022 on Flow Measurement - FLOMEKO 2022

CERN European Organization for Nuclear Research - Zenodo, Sep 19, 2022

This report was written as part of activity A 1.1.2 from the EMPIR Establishing Metrology Standar... more This report was written as part of activity A 1.1.2 from the EMPIR Establishing Metrology Standards in Microfluidic Devices (MFMET) project. The three-year European project commenced on 1 st June 2021 and focused on providing a generic methodology of accurate measurement of a particular quantity in a microfluidic device by utilising standardised methods and reference documents, e.g. VIM & GUM. For more details about this project, please visit www.mfmet.eu The help from the members of the Microfluidics Association (www.microfluidics-association.org) is greatly acknowledged.

CERN European Organization for Nuclear Research - Zenodo, Sep 19, 2022

CERN European Organization for Nuclear Research - Zenodo, Feb 4, 2022

This report was written as part of activity A1.3.5 from the EMPIR Metrology for Drug Delivery (Me... more This report was written as part of activity A1.3.5 from the EMPIR Metrology for Drug Delivery (MeDD II) project. The three-year European project commenced on 1 st June 2019 and focused on providing traceable measurements of volume, flow and pressure of existing drug delivery devices and mixing behaviour and occlusion phenomena in multi-infusion systems. For more details about this project, please visit www.drugmetrology.com

Biomedical Engineering / Biomedizinische Technik

Objectives Microflow measurement devices are used in several science and health applications, mai... more Objectives Microflow measurement devices are used in several science and health applications, mainly drug delivery. In the last decade, several new methods based on optical technology were developed, namely the front tracking and interferometric method, in which the knowledge of the inner diameter of the syringe or the capillary used is critical. Only a few National Metrology Institutes (NMIs) can perform inner diameter measurements below 1 mm, which requires expensive technology. Therefore, IPQ, in cooperation with CETIAT, CMI and UNIDEMI, under the EMPIR project 18HLT08 MeDDII – Metrology for Drug Delivery, developed new measurement methods for small inner diameter tubes based on the gravimetric principle and optical methods in order to simplify the apparatus used for this type of measurements without increasing uncertainty. Methods The gravimetric experimental setup consists of measuring the liquid volume on a specific length of the glass tube. The optical method used is based on...

BioBiomedical Engineering / Biomedizinische Technik, 2022

Objectives: Microflow measurement devices are used in several science and health applications, ma... more Objectives: Microflow measurement devices are used in
several science and health applications, mainly drug delivery. In the last decade, several new methods based on
optical technology were developed, namely the front
tracking and interferometric method, in which the knowledge of the inner diameter of the syringe or the capillary
used is critical. Only a few National Metrology Institutes
(NMIs) can perform inner diameter measurements below 1
mm, which requires expensive technology. Therefore, IPQ,
in cooperation with CETIAT, CMI and UNIDEMI, under the
EMPIR project 18HLT08 MeDDII – Metrology for Drug Delivery, developed new measurement methods for small
inner diameter tubes based on the gravimetric principle
and optical methods in order to simplify the apparatus
used for this type of measurements without increasing
uncertainty.
Methods: The gravimetric experimental setup consists of
measuring the liquid volume on a specific length of the
glass tube. The optical method used is based on the front
track principle that uses a high-resolution camera and
ImageJ software, to determine the diameter at both ends of
each capillary.
Results: To validate the developed methods, a comparison was performed between CETIAT, CMI and IPQ and the
results obtained were all consistent.

Biomedical Engineering / Biomedizinische Technik

Improving the accuracy and enabling traceable measurements of volume, flow, and pressure in exist... more Improving the accuracy and enabling traceable measurements of volume, flow, and pressure in existing drug delivery devices and in-line sensors operating at very low flow rates is essential in several fields of activities and specially in medical applications. This can only be achieved through the development of new calibrationmethods and by expanding the existing metrological infrastructure to perform micro-flow and nano-flow measurements. In this paper, we will investigate new traceable techniques for measuring flow rate, from 5 nL/min to 1,500 nL/min and present the results of an inter-comparison between nine laboratories for the calibration of two different flow meters and a syringe pump.

La méthode de mesure de référence du débit d’émission de sources neutroniques se fonde sur la tec... more La méthode de mesure de référence du débit d’émission de sources neutroniques se fonde sur la technique du bain de manganèse. Elle est destinée à étalonner des sources de neutrons utilisant des radionucléides (241AmBe, 239PuBe, 252Cf,…) en termes de débit d’émission neutronique sous 4π sr. Ce dispositif est complété par un banc de mesure de l’anisotropie d’émission utilisant un support rotatif et un compteur long de type BF3. La source à mesurer est immergée dans une solution de sulfate de manganèse et les neutrons émis sont capturés par les constituants du bain. Dans une configuration classique (sphère de bain de manganèse de 1 m de diamètre et solution concentrée), environ la moitié de ces neutrons conduisent à la création de 56Mn par réaction (n, γ) sur 55Mn. Le radionucléide 56Mn a une période radioactive d’environ 2,6 heures et le bain de manganèse atteint son activité de saturation en 56Mn quand le nombre d’atomes radioactifs créés par unité de temps devient égal au nombre d’a...

Microflow measurement devices are used in several science and health applications, mainly drug de... more Microflow measurement devices are used in several science and health applications, mainly drug delivery. In the last decade, several new methods based on optical technology were developed, namely the front tracking and interferometric method, in which the knowledge of the inner diameter of the syringe or the capillary used is critical. There are only a very few National Metrology Institutes (NMIs) that can perform diameter measurements below 10 mm, which needs very expensive technology. Therefore, the Volume and Flow Laboratory (LVC) of the Portuguese Institute for Quality (IPQ), in cooperation with CETIAT, CMI and the Department of Mechanical and Industrial Engineering (DEMI) of The New University of Lisbon, under the EMPIR project MeDDII, developed new measurement methods for small inner diameters tubes based on the gravimetric principle and optical methods. The gravimetric experimental setup consists of measuring the liquid volume on a specific length of the glass tube. Knowing t...

This report was written as part of activity 2.1.1 from the EMPIR Establishing Metrology Standards... more This report was written as part of activity 2.1.1 from the EMPIR Establishing Metrology Standards in Microfluidic Devices (MFMET) project. The three-year European project commenced on 1^st June 2021 and focused on providing a generic methodology of accurate measurement of a particular quantity in a microfluidic device by utilising standardised methods and reference documents, e.g. VIM & GUM. For more details about this project, please visit www.mfmet.eu The document provides a description of a generic methodology of accurate measurement of a quantity by utilizing standardized methods and reference documents, e.g. VIM (International Vocabulary of Metrology) & GUM (Evaluation of measurement data – Guide to the expression of uncertainty in measurement).

This document presents the scientific and technical objectives, state of the art and expected pro... more This document presents the scientific and technical objectives, state of the art and expected progress beyond it, and most importantly the expected impact on metrology, science, standards, and society of the new joint research project - MeDD II, Metrology for drug delivery (follow up of project MeDD I). It was selected for funding through the EURAMET EMPIR program of the European Commission and the participating countries. The project starts in June 2019 and will last for three years. It involves 15 partners from National and Designated Metrology Institutes, companies, and academia. The main objective is to enable traceable measurements of volume, flow and pressure of existing drug delivery devices (for example infusion pumps and analysers) and inline sensors that work at flow rates lower than 100 nL/min, in order to prevent inaccurate measurement results. This project will also investigate fast changing flow rates, liquid mixing behaviour and occlusion phenomena in multi-infusion s...

Flow Measurement and Instrumentation, 2022

Mesures physiques, 2020

Cet article traite de la mesure et du controle de niveau de liquides dans un contexte industriel.... more Cet article traite de la mesure et du controle de niveau de liquides dans un contexte industriel. Les differents chapitres decrivent les differents principes de mesure et technologies presentes sur le marche, en exposant pour chacun le processus de mesure et ses variantes, les bonnes pratiques de mise en œuvre, les avantages et inconvenients de la technologie, les parametres d'influence de l'exactitude de mesure, les regles pratiques et, le cas echeant, legales. Les differentes technologies exposees - a visualisation directe de fluides, a flotteur ou plongeur, par mesure de pression, par dissipation thermique - permettent de repondre a la totalite des problematiques industrielles en selectionnant la solution la plus adaptee au besoin.

Overall Objective: Using input from A1.2.1-A1.2.4, CETIAT, NEL, IPQ, CMI, RISE, METAS and THL wil... more Overall Objective: Using input from A1.2.1-A1.2.4, CETIAT, NEL, IPQ, CMI, RISE, METAS and THL will write a report on calibration methods for measuring the response or delay time of drug delivery devices using Newtonian liquids for flow rates from 5 nL/min to 100 nL/min.<br> Once agreed by the consortium, the coordinator will then submit the report to EURAMET as D1: 'Report on calibration methods for measuring the response or delay time of drug delivery devices using Newtonian liquids for flow rates from 5 nL/min to 100 nL/min'.

19th International Congress of Metrology (CIM2019), 2019

According to its mission of national reference laboratory, LNE-CETIAT maintains and develops the ... more According to its mission of national reference laboratory, LNE-CETIAT maintains and develops the French standard for liquid water flow meters calibration from 1g.h-1 to 36 t.h-1. The reference calibration facilities at LNE-CETIAT are historically based on the flying start and stop gravimetric method. Because of the specificity of micro-flow rates, two separated and dedicated calibration benches are used for flow rates from 1 g.h-1 to 10 kg.h-1 on one side, and from 8 kg.h-1 to 36 t.h-1 on the other side. Continuous improvement of the calibration capabilities pushes LNE-CETIAT to upgrade the existing methods toward a dynamic measurement of the reference flow rate, in the scope of EURAMET EMPIR "METROWAMET" JRP in which CETIAT is a partner of the consortium. After a short review of the state of the art and a description of the current LNE-CETIAT's, this paper will first present the development of a dynamic liquid flow generator required to ensure the measurand's repr...

Cet article traite des differentes methodes d'etalonnage et de verification de debitmetres et... more Cet article traite des differentes methodes d'etalonnage et de verification de debitmetres et compteurs de liquide. Les principes de mesure, modeles de mesure des grandeurs de reference et incertitudes associees sont presentes pour chaque methode. Un bilan d'incertitudes d'etalonnage est presente a titre d'exemple pour les methodes gravimetriques, volumetriques et par comparaison a un debitmetre etalon. Les bonnes pratiques, parametres d'influence et l'expression des resultats d'etalonnage et de leurs incertitudes associees, necessaire a la bonne mise en œuvre des etalonnages en debitmetrie liquide, sont egalement abordes.