Vitalii Kaliberdenko | V.I. Vernadsky Crimean Federal University (original) (raw)

Papers by Vitalii Kaliberdenko

Reviews on Recent Clinical Trials

Background: One of the most important problem associated with treatment of the rheumatoid arthrit... more Background: One of the most important problem associated with treatment of the rheumatoid arthritis (RA) is erosive-ulcerative lesions (EUL) of the gastroduodenal zone, which is associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs). Aim: Aim of our research is to study the clinical and histo-morphological criteria for the formation of the EUL of the gastroduodenal zone in patients with RA. Methods: Patients were divided into 3 groups, depending on the presence of an EUL, according to fibrogastroduodenoscopy (FGDS) data with a negative test for H. pylori. Group 1 included RA patients without EUL (n = 18), group 2 RA patients with erosive lesions of the gastroduodenal zone (n = 57), group 3 consisted of RA patients with ulcerative lesions (n = 17). As a norm, we used data from a survey of 18 healthy donors corresponding to RA patient’s age and sex distribution, where no somatic pathology was revealed. GSRS questionnaire used for assessment of subjective symptoms. F...

Current Rheumatology Reviews, 2021

Background: Cryopyrin-Associated Periodic Syndrome (CAPS) is a variety of clinical variants of au... more Background: Cryopyrin-Associated Periodic Syndrome (CAPS) is a variety of clinical variants of autoinflammatory diseases. The pathology is based on a mutation in the NLRP3 gene encoding the cryopyrin protein, which leads to the uncontrolled production of interleukin-1β. Particular attention should be paid to the rarity of this disease and the lack of clinical knowledge about it in therapeutic and rheumatological practice, which leads to an erroneous diagnosis and the appointment of ineffective treatment for a long time, leading to the progression of the disease and disability of the patient. Case Presentation: This article describes a clinical case of this disease. The first manifestations of the disease in a woman appeared from the age of 2 years, in the form of a rash and fever. Since school age, there have been signs of arthritis. By the age of 24, sensorineural hearing loss and pain in the spine were evident. The disease occurred under the clinical manifestations of spondyloarth...

Tavricheskiy Mediko-Biologicheskiy Vestnik

Currently, pandemic caused by coronavirus infection is the most acute and serious problem in the ... more Currently, pandemic caused by coronavirus infection is the most acute and serious problem in the world. It’s known that the virus damage`s the alveocytes of the lungs, causing pneumonia and / or acute respiratory distress syndrome. However, it is not only the lungs are targeted by SARS-CoV-2. The article provides an overview of cases of heart damage in sick sufferers COVID-19 infection. We have studied foreign and domestic scientific publications concerning cases of damage to the cardiovascular system in general, and the heart in particular. The study, analysis and review of the data was carried out from December 2019 to June 2020. Scientific papers on this topic have been found on platforms such as PubMed, Europe PubMed Central, Elsevier Science Direct, Elsevier Open Science, Springer Open, Bielefeld Academic Search Engine, and Scientific electronic library eLibrary.ru.

Nauchno-prakticheskii zhurnal «Patogenez», 2020

Актуальность. Поскольку роль эндотоксина в индукции бронхообструктивного синдрома сегодня уже не ... more Актуальность. Поскольку роль эндотоксина в индукции бронхообструктивного синдрома сегодня уже не вызывает сомнений, представляется целесообразным и определение роли антиэндотоксинового иммунитета (АЭИ) в формировании различных биофенотипов хронического воспаления, которые лежат в основе особенностей течения бронхиальной астмы (БА). Цель настоящего исследования - определение роли гуморального и мукозального звеньев АЭИ и системного воспаления при различных биофенотипах воспаления у больных БА, которые могли бы быть полезны для разработки персонифицированной терапии. Материалы и методы. В исследование включены 109 больных с верифицированным диагнозом среднетяжёлой и тяжёлой бронхиальной астмы. Пациенты были разделены на 3 группы в зависимости от типа воспаления в дыхательных путях: 1-я группа - эозинофильный, 2-я группа - нейтрофильный, 3-я группа - смешанный гранулоцитарный. Гуморальное и мукозальное звенья эндотоксин-связывающих систем оценивали по уровням специфических эндотоксин-с...

Reviews on recent clinical trials, 2020

BACKGROUND Under normal physiological conditions, endotoxin (ET) released during self-renewal of ... more BACKGROUND Under normal physiological conditions, endotoxin (ET) released during self-renewal of the colibacillus pool is an obligate stimulus for the formation of the immune system and homeostasis of the body. Violation of the barrier function of the intestinal wall and the mechanisms of neutralization of endotoxin leads to systemic endotoxemia of intestinal origin. It's development is facilitated by: stress, intoxication, a decrease in nonspecific resistance of the body, as well as damage to the intestinal mucosa and dysbiosis, where the mucous membrane is more vulnerable and permeable to endotoxin. PURPOSE OF THE RESEARCH To compare and assess the severity and nature of hepatocyte damage from endotoxin exposure and the degree of manifestation of stress due to oxidation. To determine the characteristics of structural changes in hepatocytes and to assess the oxidation stress during endotoxin intoxication in the experiment with biochemical markers. MATERIALS AND METHODS The expe...

Проанализированы данные, полученные при иммуноферментном анализе крови больных с анемическим синд... more Проанализированы данные, полученные при иммуноферментном анализе крови больных с анемическим синдромом различной этиологии у 87 больных. Выявлено повышение уровня тропонина I у 14 обследованных пациентов с гемической гипоксией на фоне анемического синдрома различной степени тяжести. Обнаружена взаимосвязь между уровнем тропонина и степенью тяжестью анемии.

У больных возрастом 35-45 лет с сахарным диабетом первого и второго типа проведен сравнительный с... more У больных возрастом 35-45 лет с сахарным диабетом первого и второго типа проведен сравнительный скрининговый анализ когнитивных дисфункций. Расстройства когнитивных функций чаще обнаруживались у больных диабетом второго типа, причем за счет увеличения доли преддементных умеренных когнитивных расстройств. Для диабета второго типа характерно преобладание когнитивных дисфункций у мужчин, за счет легких и умеренных когнитивные расстройств в сумме отмечающихся в два раза чаще, чем у женщин. При этом у женщин с диабетом второго типа когнитивных расстройств не обнаруживалось в 52% случаев, что чаще чем у мужчин в 2,6 раза.

Indian Journal of Public Health Research & Development, 2019

At present, the question of the effectiveness of the use of bioflavonoids in the treatment of the... more At present, the question of the effectiveness of the use of bioflavonoids in the treatment of the alcoholic liver disease is of practical interest and attention from modern medicine. Aim of our research is to analyse the antioxidant properties of Enoant in alcoholic liver and to establish the ultra morphostructural changes in liver tissue. Materials and methods - assessment of changes in alcohol-impaired rat liver were studied before and after administration of Enoant bioflavonoid concentrate. Results - The positive effect of “Enoant” is explained by the antioxidant properties of bioflavonoids, their ability to reduce peroxidation of proteins, stimulate reparative processes, activate protein synthesis and enhance the system of antioxidant protection of hepatocytes. All this allows to attribute the concentrate of bioflavonoids “Enoant” to highly active hepatoprotectors and is of practical interest at all stages of treatment of patients with different stages of liver lesions.

У больных с эпилепсией и эпилептическими синдромами проведен сравнительный анализ когнитивных рас... more У больных с эпилепсией и эпилептическими синдромами проведен сравнительный анализ когнитивных расстройств. Установлено, что выраженность когнитивных расстройств при эписиндромах у пациентов идущих на медико-социальную экспертную комиссию растет в следующем порядке: 1) идиопатическая эпилепсия (соответствует легким когнитивным расстройствам); 2) эписиндром алкогольного генеза, в результате черепно-мозговой травмы и нейрохирургический постоперационный эписиндром, соответствуют умеренным когнитивным расстройствам; 3) эписиндром при цереброваскулярной патологии, соответствует легкой деменции.

Indian Journal of Public Health Research & Development

У больных раком молочной железы проведен анализ личностного профиля с помощью опросника ММPI. Обн... more У больных раком молочной железы проведен анализ личностного профиля с помощью опросника ММPI. Обнаружено значимое увеличение уровня депрессии, истерии, психастении, паранойяльности как в периоде постановки диагноза так и в отдалённом периоде после хирургического лечения. Это указывает на необходимость использовать психокоррекционные методики на всех этапах лечения.

Journal of Pediatric Neurology

A retrospective multicenter chart review was conducted with the objective of evaluating the hypot... more A retrospective multicenter chart review was conducted with the objective of evaluating the hypothesis that certain cases diagnosed as tension-type headache (TTH) in pediatric neurology are not stress-related or central sensitization-related conditions but may mimic an autoimmune disorder of the dura mater. Of the 29,642 patient charts reviewed, 12,424 charts (42%) were excluded because of incomplete data and 17,218 cases were analyzed. For all the 29,642 charts, TTH or chronic daily headaches were diagnosed in 29.2% of cases. Among the 17,218 cases subjected to detailed diagnostic procedures, TTH was diagnosed in only 5%. In 7,044 cases, the initial diagnosis of TTH was changed to headache attributed to infection (87.4%), which was supported by the presence of meningeal signs, high antistreptolysin-O titers, and, in 46% of cases, magnetic resonance imaging (MRI)-detected thickening of the cranial dura mater. The initial diagnosis of migraine was confirmed in 87.7% of cases (8,034/9...

Central Nervous System Agents in Medicinal Chemistry

Background: Motion sickness occurs worldwide in healthy individuals regardless of age, ethnicity,... more Background: Motion sickness occurs worldwide in healthy individuals regardless of age, ethnicity, or gender. It is an acute disorder; it can also present as a chronic disorder in some individuals. Motion sickness not only includes vomiting and nausea, but also includes other features such as pallor of varying degrees, cold sweating, headache, drowsiness, increased salivation, and cranial pain, which are severe. Some of the other assessment scales can interpret sickness on exposure to virtual or visual stimulation and while travelling in different types of transport. Aim: The aim of our research is to study the effect of the drug on the level of blood flow and vascular reactivity of cerebral vessels when simulating changes in the cerebral circulation in terrestrial conditions characteristic of hypogravity. Methods: Chronic experiments were performed on non-anesthetized rabbits with large hemispheres, thalamus and hypothalamus were implanted with the needle-platinum electrodes 150 mm ...

Current Womens Health Reviews

: Letter to the editor on research article entitled “Development of Secondary Osteoporosis in Tee... more : Letter to the editor on research article entitled “Development of Secondary Osteoporosis in Teenage Girls with Menstrual Disorders” by Popova-Petrosyan E.V, Shanmugaraj Kulanthaivel and Keerthanaa Balasundaram which was published in CWHR. Nowadays we have more research and review papers available on osteoporosis in post menopausal women, however we are still lacking on researches for osteoporosis in teenage girls in our current literature. Authors did a wonderful research work in the field of Obstetrics and Gynecology. This research paper has significant and appreciable scope in the field of pediatrics and pediatric gynecology as well. It is really interesting and exciting, because there is no research paper published on osteoporosis in teenage girls due to menstrual disorders such as oligomenorrhea, secondary amenorrhea and polymenorrhea. As osteoporosis is one of the emerging medical and socioeconomic threat we need more researches similar to this, in order to improve the women health in future. Hereby we would like to appreciate the work of authors on their significant and interesting research paper. Further we are eagerly expecting more researches like this from “Current Women`s Health Reviews”.

Arterial Hypertension

Background: Calcium is the most common cation in the human body. An abnormal distribution of intr... more Background: Calcium is the most common cation in the human body. An abnormal distribution of intracellular and extracellular ionized Ca plays a significant role in the formation of arterial hypertension. The purpose of the study is to analyze the fractional composition of calcium in blood serum and urinary calcium excretion in patients with hypertension, as well as to identify the features of the distribution of these. Material and methods: The study included 80 patients. The population of the study consisted of 60 patients with various degrees of hypertension (38 women and 22 men) aged from 65 to 74 years old and the control group composed of 20 patients (12 men and 8 women) in the same age group without signs of hypertension. The patients with clinically expressed coronary heart disease requiring specific therapy, heart defects, impaired liver function and impaired kidney function were excluded from this study. Patients were divided into three groups, according to the World Health Organization (WHO) classification of arterial hypertension. Indicators of calcium concentration in blood and urine were determined using test kits for determining calcium with glyoxal bis-2 hydroxyanil from LACHEMA. To determine the ionized calcium, a standard technique of ion-selective electrode was used. Results and conclusion: 1. In patients with arterial hypertension, a redistribution of the calcium pool in the blood is noted due to a decrease in the concentration of ionized calcium and an increase in the bound calcium, depending on the severity of the disease. 2. An increase in urinary calcium excretion in patients with arterial hypertension is characteristic of moderate and severe forms of arterial hypertension, which given the age of patients, may be one of the causes of osteoporosis. 3. The increase in the level of intracellular calcium with the progression of arterial hypertension is an example of pathophysiological reactions that occur at the body level, the result of which can be not only banal muscle constriction but also a violation of the synthesis and production of biologically active substances that regulate blood pressure.

Current Womens Health Reviews

Background:: The actual question on the health care system all over the world is gender inequity ... more Background:: The actual question on the health care system all over the world is gender inequity in some specialties. In spite of different influencing factors for choosing their specialty by medical students and residents, the recent research studies show that gender is significantly influencing on their specialty. Especially gender disparity or inequity is mostly seen in the field of Obstetrics and gynecology. Aim of the Research:: The purpose of our study is to understand the actual problems for male specialists in the field of obstetrics and gynecology in health care system and to understand how it affects the nation’s health care system and to analyze the possible solutions. Materials and Methods:: The research consists of 815 respondents, which includes medical students, obstetricians and gynecologists and ObsGyn patients. Average age of the respondents were 20 - 50 years. They were divided into three groups. Questionnaire consists of 15 different questions for each group of p...

Reviews on Recent Clinical Trials

Introduction: Common purulent peritonitis is one of the most formidable complications in abdomina... more Introduction: Common purulent peritonitis is one of the most formidable complications in abdominal surgery. Evidence of this is the continuing high mortality rate, which according to various authors, ranges from 11% to 83%. According to modern concepts, the leading role in the development and progression of widespread purulent peritonitis is assigned to enteric insufficiency syndrome (EIS), which occurs in 90-100% of cases. Aim: The aim of the study was to improve the treatment outcomes of patients with peritonitis complicated by the development of enteric insufficiency syndrome and also by developing and introducing into clinical practice a complex of therapeutic measures, including the combined use of enterosorption in combination with antioxidant and antihypoxant therapy. Materials and Methods: The evaluation of the effectiveness of the proposed complex therapeutic measures was carried out on the basis of a prospective examination of 83 patients (26 men and 57 women) aged 24 to 7...

Journal of Pediatric Neurology

A retrospective multicenter chart review was conducted with the objective of evaluating the hypot... more A retrospective multicenter chart review was conducted with the objective of evaluating the hypothesis that certain cases diagnosed as tension-type headache (TTH) in pediatric neurology are not stress-related or central sensitization-related conditions but may mimic an autoimmune disorder of the dura mater. Of the 29,642 patient charts reviewed, 12,424 charts (42%) were excluded because of incomplete data and 17,218 cases were analyzed. For all the 29,642 charts, TTH or chronic daily headaches were diagnosed in 29.2% of cases. Among the 17,218 cases subjected to detailed diagnostic procedures, TTH was diagnosed in only 5%. In 7,044 cases, the initial diagnosis of TTH was changed to headache attributed to infection (87.4%), which was supported by the presence of meningeal signs, high antistreptolysin-O titers, and, in 46% of cases, magnetic resonance imaging (MRI)-detected thickening of the cranial dura mater. The initial diagnosis of migraine was confirmed in 87.7% of cases (8,034/9...

Reviews on Recent Clinical Trials

Introduction: Coronavirus is a group of viruses which causes diseases in mammals and birds. In hu... more Introduction: Coronavirus is a group of viruses which causes diseases in mammals and birds. In humans, these family of viruses can cause the respiratory infections from mild form to fatal forms. It is preferably called as coronavirus. Formally it known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or 2019 novel coronavirus (2019- nCoV) and this disease is called as coronavirus disease 2019 (COVID-19). SARS-CoV-2 is infectious in humans and world health organization has announced that Covid-19 as a pandemic disease. Tocilizumab is a biological agent which inhibits the cytokine, interleukin 6 (IL-6 inhibitor). As SARS-CoV-2 infection leads to the development of cytokine storm syndrome, the drug tocilizumab seems to have positive effect in patients with covid-19. Purpose of the Study: To analyze and review the possible effects and efficacy of the tocilizumab (monoclonal antibody against IL-6 receptors) in SARS-CoV-2 patients. Materials and methods: The search strategy...

Reviews on Recent Clinical Trials

Background: One of the most important problem associated with treatment of the rheumatoid arthrit... more Background: One of the most important problem associated with treatment of the rheumatoid arthritis (RA) is erosive-ulcerative lesions (EUL) of the gastroduodenal zone, which is associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs). Aim: Aim of our research is to study the clinical and histo-morphological criteria for the formation of the EUL of the gastroduodenal zone in patients with RA. Methods: Patients were divided into 3 groups, depending on the presence of an EUL, according to fibrogastroduodenoscopy (FGDS) data with a negative test for H. pylori. Group 1 included RA patients without EUL (n = 18), group 2 RA patients with erosive lesions of the gastroduodenal zone (n = 57), group 3 consisted of RA patients with ulcerative lesions (n = 17). As a norm, we used data from a survey of 18 healthy donors corresponding to RA patient’s age and sex distribution, where no somatic pathology was revealed. GSRS questionnaire used for assessment of subjective symptoms. F...

Current Rheumatology Reviews, 2021

Background: Cryopyrin-Associated Periodic Syndrome (CAPS) is a variety of clinical variants of au... more Background: Cryopyrin-Associated Periodic Syndrome (CAPS) is a variety of clinical variants of autoinflammatory diseases. The pathology is based on a mutation in the NLRP3 gene encoding the cryopyrin protein, which leads to the uncontrolled production of interleukin-1β. Particular attention should be paid to the rarity of this disease and the lack of clinical knowledge about it in therapeutic and rheumatological practice, which leads to an erroneous diagnosis and the appointment of ineffective treatment for a long time, leading to the progression of the disease and disability of the patient. Case Presentation: This article describes a clinical case of this disease. The first manifestations of the disease in a woman appeared from the age of 2 years, in the form of a rash and fever. Since school age, there have been signs of arthritis. By the age of 24, sensorineural hearing loss and pain in the spine were evident. The disease occurred under the clinical manifestations of spondyloarth...

Tavricheskiy Mediko-Biologicheskiy Vestnik

Currently, pandemic caused by coronavirus infection is the most acute and serious problem in the ... more Currently, pandemic caused by coronavirus infection is the most acute and serious problem in the world. It’s known that the virus damage`s the alveocytes of the lungs, causing pneumonia and / or acute respiratory distress syndrome. However, it is not only the lungs are targeted by SARS-CoV-2. The article provides an overview of cases of heart damage in sick sufferers COVID-19 infection. We have studied foreign and domestic scientific publications concerning cases of damage to the cardiovascular system in general, and the heart in particular. The study, analysis and review of the data was carried out from December 2019 to June 2020. Scientific papers on this topic have been found on platforms such as PubMed, Europe PubMed Central, Elsevier Science Direct, Elsevier Open Science, Springer Open, Bielefeld Academic Search Engine, and Scientific electronic library eLibrary.ru.

Nauchno-prakticheskii zhurnal «Patogenez», 2020

Актуальность. Поскольку роль эндотоксина в индукции бронхообструктивного синдрома сегодня уже не ... more Актуальность. Поскольку роль эндотоксина в индукции бронхообструктивного синдрома сегодня уже не вызывает сомнений, представляется целесообразным и определение роли антиэндотоксинового иммунитета (АЭИ) в формировании различных биофенотипов хронического воспаления, которые лежат в основе особенностей течения бронхиальной астмы (БА). Цель настоящего исследования - определение роли гуморального и мукозального звеньев АЭИ и системного воспаления при различных биофенотипах воспаления у больных БА, которые могли бы быть полезны для разработки персонифицированной терапии. Материалы и методы. В исследование включены 109 больных с верифицированным диагнозом среднетяжёлой и тяжёлой бронхиальной астмы. Пациенты были разделены на 3 группы в зависимости от типа воспаления в дыхательных путях: 1-я группа - эозинофильный, 2-я группа - нейтрофильный, 3-я группа - смешанный гранулоцитарный. Гуморальное и мукозальное звенья эндотоксин-связывающих систем оценивали по уровням специфических эндотоксин-с...

Reviews on recent clinical trials, 2020

BACKGROUND Under normal physiological conditions, endotoxin (ET) released during self-renewal of ... more BACKGROUND Under normal physiological conditions, endotoxin (ET) released during self-renewal of the colibacillus pool is an obligate stimulus for the formation of the immune system and homeostasis of the body. Violation of the barrier function of the intestinal wall and the mechanisms of neutralization of endotoxin leads to systemic endotoxemia of intestinal origin. It's development is facilitated by: stress, intoxication, a decrease in nonspecific resistance of the body, as well as damage to the intestinal mucosa and dysbiosis, where the mucous membrane is more vulnerable and permeable to endotoxin. PURPOSE OF THE RESEARCH To compare and assess the severity and nature of hepatocyte damage from endotoxin exposure and the degree of manifestation of stress due to oxidation. To determine the characteristics of structural changes in hepatocytes and to assess the oxidation stress during endotoxin intoxication in the experiment with biochemical markers. MATERIALS AND METHODS The expe...

Проанализированы данные, полученные при иммуноферментном анализе крови больных с анемическим синд... more Проанализированы данные, полученные при иммуноферментном анализе крови больных с анемическим синдромом различной этиологии у 87 больных. Выявлено повышение уровня тропонина I у 14 обследованных пациентов с гемической гипоксией на фоне анемического синдрома различной степени тяжести. Обнаружена взаимосвязь между уровнем тропонина и степенью тяжестью анемии.

У больных возрастом 35-45 лет с сахарным диабетом первого и второго типа проведен сравнительный с... more У больных возрастом 35-45 лет с сахарным диабетом первого и второго типа проведен сравнительный скрининговый анализ когнитивных дисфункций. Расстройства когнитивных функций чаще обнаруживались у больных диабетом второго типа, причем за счет увеличения доли преддементных умеренных когнитивных расстройств. Для диабета второго типа характерно преобладание когнитивных дисфункций у мужчин, за счет легких и умеренных когнитивные расстройств в сумме отмечающихся в два раза чаще, чем у женщин. При этом у женщин с диабетом второго типа когнитивных расстройств не обнаруживалось в 52% случаев, что чаще чем у мужчин в 2,6 раза.

Indian Journal of Public Health Research & Development, 2019

At present, the question of the effectiveness of the use of bioflavonoids in the treatment of the... more At present, the question of the effectiveness of the use of bioflavonoids in the treatment of the alcoholic liver disease is of practical interest and attention from modern medicine. Aim of our research is to analyse the antioxidant properties of Enoant in alcoholic liver and to establish the ultra morphostructural changes in liver tissue. Materials and methods - assessment of changes in alcohol-impaired rat liver were studied before and after administration of Enoant bioflavonoid concentrate. Results - The positive effect of “Enoant” is explained by the antioxidant properties of bioflavonoids, their ability to reduce peroxidation of proteins, stimulate reparative processes, activate protein synthesis and enhance the system of antioxidant protection of hepatocytes. All this allows to attribute the concentrate of bioflavonoids “Enoant” to highly active hepatoprotectors and is of practical interest at all stages of treatment of patients with different stages of liver lesions.

У больных с эпилепсией и эпилептическими синдромами проведен сравнительный анализ когнитивных рас... more У больных с эпилепсией и эпилептическими синдромами проведен сравнительный анализ когнитивных расстройств. Установлено, что выраженность когнитивных расстройств при эписиндромах у пациентов идущих на медико-социальную экспертную комиссию растет в следующем порядке: 1) идиопатическая эпилепсия (соответствует легким когнитивным расстройствам); 2) эписиндром алкогольного генеза, в результате черепно-мозговой травмы и нейрохирургический постоперационный эписиндром, соответствуют умеренным когнитивным расстройствам; 3) эписиндром при цереброваскулярной патологии, соответствует легкой деменции.

Indian Journal of Public Health Research & Development

У больных раком молочной железы проведен анализ личностного профиля с помощью опросника ММPI. Обн... more У больных раком молочной железы проведен анализ личностного профиля с помощью опросника ММPI. Обнаружено значимое увеличение уровня депрессии, истерии, психастении, паранойяльности как в периоде постановки диагноза так и в отдалённом периоде после хирургического лечения. Это указывает на необходимость использовать психокоррекционные методики на всех этапах лечения.

Journal of Pediatric Neurology

A retrospective multicenter chart review was conducted with the objective of evaluating the hypot... more A retrospective multicenter chart review was conducted with the objective of evaluating the hypothesis that certain cases diagnosed as tension-type headache (TTH) in pediatric neurology are not stress-related or central sensitization-related conditions but may mimic an autoimmune disorder of the dura mater. Of the 29,642 patient charts reviewed, 12,424 charts (42%) were excluded because of incomplete data and 17,218 cases were analyzed. For all the 29,642 charts, TTH or chronic daily headaches were diagnosed in 29.2% of cases. Among the 17,218 cases subjected to detailed diagnostic procedures, TTH was diagnosed in only 5%. In 7,044 cases, the initial diagnosis of TTH was changed to headache attributed to infection (87.4%), which was supported by the presence of meningeal signs, high antistreptolysin-O titers, and, in 46% of cases, magnetic resonance imaging (MRI)-detected thickening of the cranial dura mater. The initial diagnosis of migraine was confirmed in 87.7% of cases (8,034/9...

Central Nervous System Agents in Medicinal Chemistry

Background: Motion sickness occurs worldwide in healthy individuals regardless of age, ethnicity,... more Background: Motion sickness occurs worldwide in healthy individuals regardless of age, ethnicity, or gender. It is an acute disorder; it can also present as a chronic disorder in some individuals. Motion sickness not only includes vomiting and nausea, but also includes other features such as pallor of varying degrees, cold sweating, headache, drowsiness, increased salivation, and cranial pain, which are severe. Some of the other assessment scales can interpret sickness on exposure to virtual or visual stimulation and while travelling in different types of transport. Aim: The aim of our research is to study the effect of the drug on the level of blood flow and vascular reactivity of cerebral vessels when simulating changes in the cerebral circulation in terrestrial conditions characteristic of hypogravity. Methods: Chronic experiments were performed on non-anesthetized rabbits with large hemispheres, thalamus and hypothalamus were implanted with the needle-platinum electrodes 150 mm ...

Current Womens Health Reviews

: Letter to the editor on research article entitled “Development of Secondary Osteoporosis in Tee... more : Letter to the editor on research article entitled “Development of Secondary Osteoporosis in Teenage Girls with Menstrual Disorders” by Popova-Petrosyan E.V, Shanmugaraj Kulanthaivel and Keerthanaa Balasundaram which was published in CWHR. Nowadays we have more research and review papers available on osteoporosis in post menopausal women, however we are still lacking on researches for osteoporosis in teenage girls in our current literature. Authors did a wonderful research work in the field of Obstetrics and Gynecology. This research paper has significant and appreciable scope in the field of pediatrics and pediatric gynecology as well. It is really interesting and exciting, because there is no research paper published on osteoporosis in teenage girls due to menstrual disorders such as oligomenorrhea, secondary amenorrhea and polymenorrhea. As osteoporosis is one of the emerging medical and socioeconomic threat we need more researches similar to this, in order to improve the women health in future. Hereby we would like to appreciate the work of authors on their significant and interesting research paper. Further we are eagerly expecting more researches like this from “Current Women`s Health Reviews”.

Arterial Hypertension

Background: Calcium is the most common cation in the human body. An abnormal distribution of intr... more Background: Calcium is the most common cation in the human body. An abnormal distribution of intracellular and extracellular ionized Ca plays a significant role in the formation of arterial hypertension. The purpose of the study is to analyze the fractional composition of calcium in blood serum and urinary calcium excretion in patients with hypertension, as well as to identify the features of the distribution of these. Material and methods: The study included 80 patients. The population of the study consisted of 60 patients with various degrees of hypertension (38 women and 22 men) aged from 65 to 74 years old and the control group composed of 20 patients (12 men and 8 women) in the same age group without signs of hypertension. The patients with clinically expressed coronary heart disease requiring specific therapy, heart defects, impaired liver function and impaired kidney function were excluded from this study. Patients were divided into three groups, according to the World Health Organization (WHO) classification of arterial hypertension. Indicators of calcium concentration in blood and urine were determined using test kits for determining calcium with glyoxal bis-2 hydroxyanil from LACHEMA. To determine the ionized calcium, a standard technique of ion-selective electrode was used. Results and conclusion: 1. In patients with arterial hypertension, a redistribution of the calcium pool in the blood is noted due to a decrease in the concentration of ionized calcium and an increase in the bound calcium, depending on the severity of the disease. 2. An increase in urinary calcium excretion in patients with arterial hypertension is characteristic of moderate and severe forms of arterial hypertension, which given the age of patients, may be one of the causes of osteoporosis. 3. The increase in the level of intracellular calcium with the progression of arterial hypertension is an example of pathophysiological reactions that occur at the body level, the result of which can be not only banal muscle constriction but also a violation of the synthesis and production of biologically active substances that regulate blood pressure.

Current Womens Health Reviews

Background:: The actual question on the health care system all over the world is gender inequity ... more Background:: The actual question on the health care system all over the world is gender inequity in some specialties. In spite of different influencing factors for choosing their specialty by medical students and residents, the recent research studies show that gender is significantly influencing on their specialty. Especially gender disparity or inequity is mostly seen in the field of Obstetrics and gynecology. Aim of the Research:: The purpose of our study is to understand the actual problems for male specialists in the field of obstetrics and gynecology in health care system and to understand how it affects the nation’s health care system and to analyze the possible solutions. Materials and Methods:: The research consists of 815 respondents, which includes medical students, obstetricians and gynecologists and ObsGyn patients. Average age of the respondents were 20 - 50 years. They were divided into three groups. Questionnaire consists of 15 different questions for each group of p...

Reviews on Recent Clinical Trials

Introduction: Common purulent peritonitis is one of the most formidable complications in abdomina... more Introduction: Common purulent peritonitis is one of the most formidable complications in abdominal surgery. Evidence of this is the continuing high mortality rate, which according to various authors, ranges from 11% to 83%. According to modern concepts, the leading role in the development and progression of widespread purulent peritonitis is assigned to enteric insufficiency syndrome (EIS), which occurs in 90-100% of cases. Aim: The aim of the study was to improve the treatment outcomes of patients with peritonitis complicated by the development of enteric insufficiency syndrome and also by developing and introducing into clinical practice a complex of therapeutic measures, including the combined use of enterosorption in combination with antioxidant and antihypoxant therapy. Materials and Methods: The evaluation of the effectiveness of the proposed complex therapeutic measures was carried out on the basis of a prospective examination of 83 patients (26 men and 57 women) aged 24 to 7...

Journal of Pediatric Neurology

A retrospective multicenter chart review was conducted with the objective of evaluating the hypot... more A retrospective multicenter chart review was conducted with the objective of evaluating the hypothesis that certain cases diagnosed as tension-type headache (TTH) in pediatric neurology are not stress-related or central sensitization-related conditions but may mimic an autoimmune disorder of the dura mater. Of the 29,642 patient charts reviewed, 12,424 charts (42%) were excluded because of incomplete data and 17,218 cases were analyzed. For all the 29,642 charts, TTH or chronic daily headaches were diagnosed in 29.2% of cases. Among the 17,218 cases subjected to detailed diagnostic procedures, TTH was diagnosed in only 5%. In 7,044 cases, the initial diagnosis of TTH was changed to headache attributed to infection (87.4%), which was supported by the presence of meningeal signs, high antistreptolysin-O titers, and, in 46% of cases, magnetic resonance imaging (MRI)-detected thickening of the cranial dura mater. The initial diagnosis of migraine was confirmed in 87.7% of cases (8,034/9...

Reviews on Recent Clinical Trials

Introduction: Coronavirus is a group of viruses which causes diseases in mammals and birds. In hu... more Introduction: Coronavirus is a group of viruses which causes diseases in mammals and birds. In humans, these family of viruses can cause the respiratory infections from mild form to fatal forms. It is preferably called as coronavirus. Formally it known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or 2019 novel coronavirus (2019- nCoV) and this disease is called as coronavirus disease 2019 (COVID-19). SARS-CoV-2 is infectious in humans and world health organization has announced that Covid-19 as a pandemic disease. Tocilizumab is a biological agent which inhibits the cytokine, interleukin 6 (IL-6 inhibitor). As SARS-CoV-2 infection leads to the development of cytokine storm syndrome, the drug tocilizumab seems to have positive effect in patients with covid-19. Purpose of the Study: To analyze and review the possible effects and efficacy of the tocilizumab (monoclonal antibody against IL-6 receptors) in SARS-CoV-2 patients. Materials and methods: The search strategy...