Stellan Holgersson | Chalmers University of Technology (original) (raw)
Papers by Stellan Holgersson
A preliminary safety assessment of the deep repository for long-lived, low and intermediate level... more A preliminary safety assessment of the deep repository for long-lived, low and intermediate level waste, SFL 3-5, has been made. This report contains a compilation of data selected for the calculations of the migration of radionuclides and toxic metals from the waste to the biosphere. It also contains the data needed for the next step, which is to calculate dose to man from the far-field release figures. In the preliminary safety assessment it is assumed that SFL 3-5 is located in connection to the deep repository for spent fuel. This makes it possible to utilise site-specific information derived within the safety assessment of the deep repository for spent fuel, SR 97, for the sites Aberg, Beberg and Ceberg. When information from SR 97 is utilised, the values selected are as far as possible those proposed as a ‘reasonable estimate’ for the migration calculations in SR 97. The selection of values for parameters specific for the calculation of migration from the SFL 3-5 repository is...
Surface area / Particle size / Radionuclide / Magnetite / Plagioclase Summary. In order to assess... more Surface area / Particle size / Radionuclide / Magnetite / Plagioclase Summary. In order to assess the geochemical retention properties of rocks, which will be the final barrier for radionu-clide transport to the biosphere in the case of a failed deep underground repository for spent nuclear fuel, radionuclide sorption experiments are usually made with crushed material. This raises the issue of extrapolating results obtained from laboratory experiments to the field scale. As sorption is gen-erally related to the surface area of the geological material, it is then important to consider the dependency of the spe-cific surface area on the particle size. In this work, BET surface area determinations of samples of different particle sizes are conducted on two minerals commonly found in granite: labradorite and magnetite. The results show a linear relationship between BET surface area and the inverse of the particle size, up to a certain particle size. Furthermore, results also show that t...
Nuclear Engineering and Design, 2006
… -Rock Interaction. B. …, 2010
The specific surface area as determined by BET analysis is often used for scaling mineral surface... more The specific surface area as determined by BET analysis is often used for scaling mineral surface reaction capacities and rates between particles of different sizes as found in nature. Generally, an inverse proportionality between BET area and particle size is assumed, ...
Applied Radiation and Isotopes, 2002
Cancer biotherapy & radiopharmaceuticals, 2015
Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it ... more Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity and the complex radiochemistry of (211)At are major obstacles for research and prospective clinical applications. In the present study, astatination of immunoconjugates, already prepared well in advance before radiolabeling, was performed to investigate the possibility of formulating a kit-like reagent for the production of (211)At radiopharmaceuticals. The shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates was evaluated, that is, the effect of different storage times on the quality of the immunoconjugates. The quality being referred to is the capacity to maintain a good radiochemical yield and good cell-binding property after labeling with (211)At. The stability of the con...
A preliminary safety assessment of the deep repository for long-lived, low and intermediate level... more A preliminary safety assessment of the deep repository for long-lived, low and intermediate level waste, SFL 3-5, has been made. This report contains a compilation of data selected for the calculations of the migration of radionuclides and toxic metals from the waste to the biosphere. It also contains the data needed for the next step, which is to calculate dose to man from the far-field release figures. In the preliminary safety assessment it is assumed that SFL 3-5 is located in connection to the deep repository for spent fuel. This makes it possible to utilise site-specific information derived within the safety assessment of the deep repository for spent fuel, SR 97, for the sites Aberg, Beberg and Ceberg. When information from SR 97 is utilised, the values selected are as far as possible those proposed as a ‘reasonable estimate’ for the migration calculations in SR 97. The selection of values for parameters specific for the calculation of migration from the SFL 3-5 repository is...
Surface area / Particle size / Radionuclide / Magnetite / Plagioclase Summary. In order to assess... more Surface area / Particle size / Radionuclide / Magnetite / Plagioclase Summary. In order to assess the geochemical retention properties of rocks, which will be the final barrier for radionu-clide transport to the biosphere in the case of a failed deep underground repository for spent nuclear fuel, radionuclide sorption experiments are usually made with crushed material. This raises the issue of extrapolating results obtained from laboratory experiments to the field scale. As sorption is gen-erally related to the surface area of the geological material, it is then important to consider the dependency of the spe-cific surface area on the particle size. In this work, BET surface area determinations of samples of different particle sizes are conducted on two minerals commonly found in granite: labradorite and magnetite. The results show a linear relationship between BET surface area and the inverse of the particle size, up to a certain particle size. Furthermore, results also show that t...
Nuclear Engineering and Design, 2006
… -Rock Interaction. B. …, 2010
The specific surface area as determined by BET analysis is often used for scaling mineral surface... more The specific surface area as determined by BET analysis is often used for scaling mineral surface reaction capacities and rates between particles of different sizes as found in nature. Generally, an inverse proportionality between BET area and particle size is assumed, ...
Applied Radiation and Isotopes, 2002
Cancer biotherapy & radiopharmaceuticals, 2015
Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it ... more Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity and the complex radiochemistry of (211)At are major obstacles for research and prospective clinical applications. In the present study, astatination of immunoconjugates, already prepared well in advance before radiolabeling, was performed to investigate the possibility of formulating a kit-like reagent for the production of (211)At radiopharmaceuticals. The shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates was evaluated, that is, the effect of different storage times on the quality of the immunoconjugates. The quality being referred to is the capacity to maintain a good radiochemical yield and good cell-binding property after labeling with (211)At. The stability of the con...