Martina Mogl | Charité - Universitätsmedizin Berlin / Charité Medical University Berlin (original) (raw)

Papers by Martina Mogl

Journal of Clinical Medicine, 2022

Parathyroidectomy (PTX) is a mainstay of treating secondary hyperparathyroidism (SHPT) in patient... more Parathyroidectomy (PTX) is a mainstay of treating secondary hyperparathyroidism (SHPT) in patients with kidney failure in order to reduce the incidence of cardiovascular events (CVE), increase overall survival and improve quality of life. Perioperative hyperkalemia may lead to devastating cardiac complications. Distinct preoperative thresholds for serum potassium levels (SPL) were defined, but neither their usefulness nor consecutive risks are understood. This study compared the results and efficacy of different clinical procedures in preventing or treating perioperative hyperkalemia, including postoperative urgent hemodialysis (UHD). Methods: Patients from Charité-Universitätsmedizin Berlin and Rheinland Klinikum Lukaskrankenhaus, Neuss, undergoing PTX due to SHPT between 2008 and 2018 were analyzed retrospectively with regard to demographic parameters, surgery specific conditions and perioperative laboratory results. Comparisons of patient values from both centers with focus on pe...

Allgemein- und Viszeralchirurgie II, 2022

Background: Reoperations for persistent or recurrent renal hyperparathyroidism are often extremel... more Background: Reoperations for persistent or recurrent renal hyperparathyroidism are often extremely difficult and require exact preoperative imaging. Even in experienced centers, failure and complication rates are relatively high. Materials and methods: We performed a retrospective analysis of 547[for full text, please go to the a.m. URL]

Background: The number of parathyroidectomies steadily decreased from 36 per year to 15 per year ... more Background: The number of parathyroidectomies steadily decreased from 36 per year to 15 per year between 2008 (approval of cinacalcet for use in rHPT) and 2012 at our institution. Since 2014, the number is increasing again. Materials and methods: The perioperative course of parathyroidectomy with[for full text, please go to the a.m. URL]

Simple Summary Quantification of liver metastases on imaging is of utmost importance in therapy r... more Simple Summary Quantification of liver metastases on imaging is of utmost importance in therapy response assessment, wherein gadoxetic acid (Gd-EOB)-enhanced magnetic resonance imaging (MRI) shows the highest accuracy. Common criteria for assessing therapy response simplify measuring liver metastasis, as full 3D quantification is very time-consuming. Therefore, we trained a deep-learning model using manual 3D segmentation of liver metastases and hepatic parenchyma in 278 Gd-EOB MRI scans of 149 patients with neuroendocrine neoplasms (NEN). The clinical relevance of the model was evaluated in 33 additional consecutive patients with NEN and liver metastases, comparing the model’s segmentation of baseline and follow-up examinations with the therapy response evaluation of an expert multidisciplinary cancer conference (MCC). The model showed high accuracy in quantifying liver metastases and hepatic tumor load, and its measurements matched the response evaluation of an MCC so that its use...

Kidney International, 2021

Deutsches Aerzteblatt Online, 2021

Biomedical Optics Express, 2011

Micrometer-sized iron oxide particles (MPIOs) attract increasing interest as contrast agents for ... more Micrometer-sized iron oxide particles (MPIOs) attract increasing interest as contrast agents for cellular tracking by clinical Magnetic Resonance Imaging (MRI). Despite the great potential of MPIOs for in vivo imaging of labeled cells, little is known on the intracellular localization of these particles following uptake due to the lack of techniques with the ability to monitor the particle uptake in vivo at single-cell level. Here, we show that coherent anti-Stokes Raman scattering (CARS) microscopy enables non-invasive, label-free imaging of MPIOs in living cells with submicron resolution in three dimensions. CARS allows simultaneous visualization of the cell framework and the MPIOs, where the particles can be readily distinguished from other cellular components of comparable dimensions, and localized inside the cell.

Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie, 2018

Das intraoperative Neuromonitoring (IONM) hat zunehmenden Routinecharakter in der Schilddrüsenchi... more Das intraoperative Neuromonitoring (IONM) hat zunehmenden Routinecharakter in der Schilddrüsenchirurgie in Deutschland erlangt. Dies unterscheidet sich von anderen Ländern wie z. B. den USA und UK, bei denen das intraoperative Neuromonitoring in weniger als der Hälfte der Schilddrüsenoperationen genutzt wird [1]. Für die Nutzung des IONM spricht jedoch die damit verbundene Sicherheit, postoperative Stimmbandparesen bereits intraoperativ zu detektieren und entsprechend die OP-Strategie anpassen zu können. Ob die Zahl der einseitigen N.-laryngeus-recurrens-Paresen (NLRP) dadurch gesenkt wird, ist jedoch weiterhin fraglich und hängt von unterschiedlichsten Faktoren ab.

Journal of the Pancreas, Sep 2, 2008

The development of pancreatic tissue outside the confines of the main gland represents a congenit... more The development of pancreatic tissue outside the confines of the main gland represents a congenital abnormality referred to as heterotopic pancreas. This is a rare pathological and surgical entity which remains mostly asymptomatic. We present the case of a 28-year-old male, who was admitted to hospital because of a history of blood in bowel movements. After a normal gastroscopy and colonoscopy, Tc99m-tagged red blood cells scintigraphy showed enrichment in the right lower abdomen. At double-balloon endoscopy, a intraluminal polypoid mass 8 cm in diameter was revealed 120 cm from the ileocecal valve. The initial macroscopic diagnosis was a gastrointestinal stromal tumor. During surgery, the diagnosis of heterotopic pancreas with lipoma and fibromatosis was made. To our knowledge this is the first case of ileal heterotopic pancreatic tissue and lipoma described to date in the literature. Ileal heterotopic pancreas is a rare entity with potentially life-threatening complications, local...

Springer Reference Medizin

Rare Tumors

Insulinomas are rare, benign and functional tumors that coincidentally may become overt during pr... more Insulinomas are rare, benign and functional tumors that coincidentally may become overt during pregnancy or in the post-partum period. As the general symptoms of a pregnancy might cover the clinical presentation, diagnosing remains challenging. We present one additional case of a post-partum insulinoma, combined with a systematic review of the literature to sum up relevant details in diagnosis and treatment. A systematic request of Pubmed/Medline was conducted using the following terms: “insulinoma AND pregnancy” and “insulinoma” for a second request of ClinicalTrials.gov. All publications concerning pregnant or post-partum women with insulinoma were included. Thirty-six cases could be identified for analysis. Each publication was reviewed for demographic, diagnostic and therapeutic data. The most frequent clinical signs were unconsciousness and neurological symptoms. 64.9% were diagnosed during early pregnancy and 35.1% post-partum. 91.9% underwent surgery with a third resected dur...

Molecular and Clinical Oncology

Transplantation Proceedings

International Journal of Surgical Oncology

Introduction. Adrenal metastasis of hepatocellular carcinoma (HCC) is a rare entity and can be tr... more Introduction. Adrenal metastasis of hepatocellular carcinoma (HCC) is a rare entity and can be treated by resection, local ablative therapy, or systemic therapy. Unfortunately, data about treatment outcome, especially in liver transplant recipients, are rare. Patients and Methods. From 2005 to 2015, 990 liver resections and 303 liver transplantations because of HCC were performed at our clinic. We retrospectively analyzed treatment outcome of the patients with metachronous adrenal metastasis of HCC, who received either resection, local ablation, or surveillance only. Results. 10 patients were identified (0.8%). 7 patients received liver transplantation for primary HCC therapy, 3 liver resection, and 1 a local ablative therapy. 8 patients underwent adrenalectomy (one via retroperitoneoscopy), one was treated with local ablation, and one had surveillance only. Seven out of eight patients had no surgical complications and one experienced a pancreatic fistula, treated conservatively. 37...

Visceral Medicine

Introduction: Gender-specific treatment is gaining growing attention in various fields of medicin... more Introduction: Gender-specific treatment is gaining growing attention in various fields of medicine. In gastrointestinal cancer, influence of sex on outcome has been discussed, while this has not been the case in neuroendocrine tumors. Overall, the incidence of neuroendocrine neoplasms is rising, especially for appendiceal neuroendocrine neoplasms in women. Also, women seem to have a slight advantage in response to therapy, especially for liver metastases. Objectives: This single-center analysis aimed to investigate gender-specific differences in our cohort related to distribution, therapy, and outcome. Methods: Patients from the NET registry as well as the clinic database were evaluated retrospectively concerning overall survival and response to therapy with respect to gender. A subgroup analysis was carried out for patients with low grading and response to chemotherapy, as well as for patients with good and moderate grading receiving peptide receptor radionuclide therapy and for a group of patients with liver surgery. Results: No specific differences could be detected for overall survival or response to therapy between male and female patients. Mean survival was estimated with 242.2 months (±10.39 SD) altogether and 221.7 months (± 13.02 SD) for male patients and 253.5 months (±15.24 SD) for female patients from the NET registry from initial diagnosis. There was no significant difference between female and male patients (p = 0.136). For patients receiving chemotherapy, overall survival from initial diagnosis was calculated with 26 months (±2.59) and did not show any significant differences between female and male patients 24.8 months (±2.81 SD) vs. 27.8 months (±3.86 SD, p = 0.87). Patients undergoing peptide receptor radionuclide therapy showed a median progression-free survival of 26.9 months (±2.82 SD), with 16.9 (±5.595 SD) and 26.9 months (±3.019 SD) for male and female patients, respectively (p = 0.2). In the group of patients with liver surgery, female patients reached an estimated overall survival of 64.7 months (±4.16 SD), male patients 65.1 months (±2.79 SD, p = 0.562). Conclusion: Our cohort did not reveal significant differences in outcome and response to therapy with regards to gender.

Reviews in Endocrine and Metabolic Disorders