Dr. A. M. Abu Ahmed | University of Chittagong (original) (raw)

Papers by Dr. A. M. Abu Ahmed

Research paper thumbnail of Root Exudates of Fifteen Common Weed Species: Phytochemical Screening and Allelopathic Effects on T. aestivum L

Agronomy

Through allelopathic interactions, plants may either suppress competing species or promote those ... more Through allelopathic interactions, plants may either suppress competing species or promote those that may help them better adapt to their environment. The purpose of this research was to determine how the root exudates of 15 common weeds affected the germination of wheat (Triticum aestivum L.). Every other day, 15 seeds were dispersed over Petri dishes (with filter paper) and pots (with garden soil) and treated with 1 mL and 5 mL of aqueous root exudates, respectively. Distilled water had the highest germination rate at 86.33% and the lowest at 64.00% (p = 0.001) for Commelina benghalensis in the Petri dish containing root exudates. The seed germination percentage of the pot condition was the lowest, at 68.45% (p = 0.004), for Solanum nigrum, while the control was 87.23%. Similarly, the lowest shoot length, 12.01 cm (p = 0.0025) in Mikania micrantha, and the lowest root length of 2.17 cm (p = 0.0048) in Leucas aspera, were recorded, whereas the control was 19.13 cm and 3.46 cm, resp...

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Research paper thumbnail of Correction: Water hyacinth (Eichhornia crassipes) fractions potentially normalize the lead (Pb) poisoning and enhance in vitro thrombolysis

Advances in Traditional Medicine

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Research paper thumbnail of Edible freshwater snail ( Paludomas conica ) attenuates STZ ‐induced diabetic complications by regulating PFK ‐1 and PON ‐1 gene expression

International Journal of Food Science & Technology

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Research paper thumbnail of Author response for "Edible freshwater snail ( Paludomas conica ) attenuates STZ ‐induced diabetic complications by regulating PFK ‐1 and PON ‐1 gene expression

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Research paper thumbnail of Correction: Rashid et al. Natural Compounds of Lasia spinosa (L.) Stem Potentiate Antidiabetic Actions by Regulating Diabetes and Diabetes-Related Biochemical and Cellular Indexes. Pharmaceuticals 2022, 15, 1466

Pharmaceuticals

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Research paper thumbnail of Natural Compounds of Lasia spinosa (L.) Stem Potentiate Antidiabetic Actions by Regulating Diabetes and Diabetes-Related Biochemical and Cellular Indexes

Pharmaceuticals

Natural biometabolites of plants have been reported to be useful in chronic diseases including di... more Natural biometabolites of plants have been reported to be useful in chronic diseases including diabetes and associated complications. This research is aimed to investigate how the biometabolites of Lasia spinosa methanol stem (MEXLS) extract ameliorative diabetes and diabetes-related complications. MEXLS was examined for in vitro antioxidant and in vivo antidiabetic effects in a streptozotocin-induced diabetes model, and its chemical profiling was done by gas chromatography-mass spectrometry analysis. The results were verified by histopathological examination and in silico ligand-receptor interaction of characterized natural biometabolites with antidiabetic receptor proteins AMPK (PDB ID: 4CFH); PPARγ (PDB ID: 3G9E); and mammalian α-amylase center (PDB ID: 1PPI). The MEXLS was found to show a remarkable α-amylase inhibition (47.45%), strong antioxidant action, and significant (p < 0.05) decrease in blood glucose level, serum aspartate aminotransferase (AST), alanine aminotransfer...

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Research paper thumbnail of Upregulation of Antioxidative Gene Expression by Lasia spinosa Organic Extract Improves the Predisposing Biomarkers and Tissue Architectures in Streptozotocin-Induced Diabetic Models of Long Evans Rats

Antioxidants

Plants are an entity essential to the function of the biosphere as well as human health. In the c... more Plants are an entity essential to the function of the biosphere as well as human health. In the context of human health, this research investigated the effect of Lasia spinosa (Lour) leaf methanolic extracts (LSML) on antioxidative enzymes and gene expression as well as biochemical and histological markers in a streptozotocin (STZ)-induced diabetes model. Fructose-fed streptozotocin (STZ)-induced diabetic animals were subjected to a four-week intervention followed by the assessment of the animal’s blood and tissues for enzymatic, biochemical, histological, and genetic changes. LSML-treated groups were shown to decrease plasma glucose levels and improve body and organ weights compared to the untreated group in a dose-dependent manner. At the doses of 125 and 250 mg/kg b.w., LSML were able to normalize serum, hepatic, and renal biochemical parameters and restore the pancreas, kidney, liver, and spleen tissue architectures to their native state. A considerable increase (p < 0.01) of...

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Research paper thumbnail of Incredible affinity of Kattosh with PPAR‐γ receptors attenuates STZ‐induced pancreas and kidney lesions evidenced in chemicobiological interactions

Journal of Cellular and Molecular Medicine

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Research paper thumbnail of In vitro thrombolytic assay of Alpinia zerumbet, Alpinia nigra and Urena sinuata

ijrpp.pharmascope.org

Atherothrombotic diseases are serious impacts of the thrombus formed in blood vessels. Thrombolyt... more Atherothrombotic diseases are serious impacts of the thrombus formed in blood vessels. Thrombolytic agents are used to dissolve the already formed clots in the blood vessels; but these drugs have certain limitations which can lead to serious and sometimes ...

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Research paper thumbnail of Epiphytic Acampe ochracea orchid relieves paracetamol-induced hepatotoxicity by inhibiting oxidative stress and upregulating antioxidant genes in in vivo and virtual screening

Biomedicine & Pharmacotherapy

Orchids are basically ornamental, and biological functions are seldom evaluated. This research in... more Orchids are basically ornamental, and biological functions are seldom evaluated. This research investigated the effects of Acampe ochracea methanol extract (AOME) in ameliorating the paracetamol (PCM) induced liver injury in Wistar albino rats, evaluating its phytochemical status through UPLC-qTOF-MS analysis. With molecular docking and network pharmacology, virtual screening verified the inevitable interactions between the UPLC-qTOF-MS-characterized compounds and hepatoprotective drug receptors. The AOME has explicit a dose-dependent decrease of liver enzymes acid phosphatase (ACP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), total bilirubin, as well as an increase of serum total protein and antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GSH) with a virtual normalization (p < 0.05-p < 0.001) and the values were almost equivalent to the reference drug silymarin. After pretreatment with AOME, PCM-induced malondialdehyde (MDA) levels were considerably decreased (p < 0.001). Histopathological examinations corroborated the functional and biochemical findings. The AOME upregulated the genes involved in antioxidative (CAT, SOD, β-actin, PON1, and PFK1) and hepatoprotective mechanisms in PCM intoxicated rats. An array of 103 compounds has been identified from AOME through UPLC-qTOF-MS analysis. The detected compounds were substantially related to the targets of several liver proteins and antioxidative enzymes, according to an in silico study. Virtual prediction by SwissADME and admetSAR showed that AOME has drug-like, non-toxic, and potential pharmacological activities in hepatic damage. Furthermore, VEGFA, CYP19A1, MAPK14, ESR1, and PPARG genes interact with target compounds impacting the significant biological actions to recover PCM-induced liver damage.

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Research paper thumbnail of Pretreatment of Blumea lacera leaves ameliorate acute ulcer and oxidative stress in ethanol-induced Long-Evan rat: A combined experimental and chemico-biological interaction

Biomedicine & Pharmacotherapy

Blumea lacera (Burm.f.) DC. is described as a valuable medicinal plant in various popular systems... more Blumea lacera (Burm.f.) DC. is described as a valuable medicinal plant in various popular systems of medicine. The aim of the experiment reports the in vivo antiulcer activity of methanol extract of Blumea lacera (MEBLL) and in silico studies of bioactive constituents of MEBLL. In this study, fasted Long-Evans rat treated with 80 % ethanol (0.5 mL) to induce gastric ulcer, were pretreated orally with MEBLL at different doses (250 and 500 mg/kg, p.o., b.w) and omeprazole (20 mg/kg, p.o.) and distilled water were used as a reference drug and normal control respectively. In silico activity against gastric H+-K+ATPase enzyme was also studied. The findings demonstrated that the treatment with MEBLL attenuated markedly ulcer and protected the integrity of the gastric mucosa by preventing the mucosal ulceration altered biochemical parameters of gastric juice such total carbohydrate, total protein and pepsin activity. Additionally, the experimental groups significantly (p < 0.001) inhibited gastric lesions and malondealdehyde (MDA) levels and upregulated antioxidant enzymes level. Furthermore, nine compounds were documented as bioactive, displayed good binding affinities to against gastric H+-K+ATPase enzyme while these compounds illustrated inhibitory effect. From these studies, it is established MEBLL has ulcer healing property as unveiled by in vivo and in silico studies.

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Research paper thumbnail of Thrombolytic, Cytotoxic and Antidiabetic Effects of Paederia foetida L. Leaf Extract

British Journal of Medicine and Medical Research

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Research paper thumbnail of Water hyacinth (Eichhornia crassipes fractions potentially normalize the lead (Pb) poisoning and enhance in vitro thrombolysis

Oriental Pharmacy and Experimental Medicine, 2016

Water hyacinth (Eichhornia crassipes) has been used in phytoextraction to uptake heavy metals and... more Water hyacinth (Eichhornia crassipes) has been used in phytoextraction to uptake heavy metals and trace elements in various experiments. This research investigated the protective effects of Water hyacinth extracts on Lead (Pb)-induced toxicity in the albino rat. Forty-eight six-weeks-old Wistar albino male rats (average weight, 180 ± 6.45 g) were divided into six groups: normal control (NC), Pb control (PbC), Chloroform extract (ChEx), Ethyl acetate extract (EAEx), Methanol extract (MeEx) and Ascorbic acid treated groups (AA, positive control). All animals except NC group have been administered with Lead acetate (Pb(CH3COOH)2) before the therapeutic dose. Thrombolytic and cytotoxic effects were evaluated by modified clot lysis and Brine shrimp lethality tests respectively. Biochemical analyses reports revealed that ChEx significantly (P ≤ 0.05) reduced the elevated alkaline phosphatase (ALP) and aspartate amino transferase (AST) whereas MeEx did the alanine amino transferase (ALT) in comparison to positive control. ChEx significantly inhibited the Pb deposition in kidney and liver than two other extracts. ChEx significantly increased the liver protein compared to PbC group. In the thrombolytic assay, EAEx showed the pronounced clot lysis (49.24 %) while ChEx and MeEx showed 45.18 % and 29.13 % of clot lysis respectively. In Brine shrimp lethality bioassay, the LC50 value of the ChEx, EAEx and MeEx were 4.16, 4.47 and 9.27 μg/mg respectively and values were statistically significant (p < 0.05) compared to that of reference cytotoxic agent, Vincristine sulfate (LC50’ 0.55). Histopathological screening of kidney, liver and spleen showed that ethyl acetate extract recovered the highest of the cellular damage caused by Lead acetate. Biochemical and histopathological screening, therefore, demonstrate that Water hyacinth could be one of the promising sources of normalizing the Pb-poisoning and enhancing the thrombolysis in an animal model. Therapeutic prospects of Water hyacinth could be further studied through highlighting a dose-response study.

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Research paper thumbnail of Investigation of in vivo neuropharmacological effect of Alpinia nigra leaf extract

Asian Pacific journal of tropical biomedicine, 2014

To analyze in vivo neuro-pharmacological effects of Alpinia nigra as anxiety is a particular form... more To analyze in vivo neuro-pharmacological effects of Alpinia nigra as anxiety is a particular form of behavioral inhibition that occurs in response to novel environmental events. In present study, the extract of Alpinia nigra was evaluated for its central nervous system depressant effect using mice behavioral models, such as hole cross, open field and thiopental sodium induced sleeping time tests for its sedative properties and an elevated plus-maze test for its anxiolytic potential, respectively. In anxiolytic study, the extract displayed increased percentage of entry into open arm at the dose of 400 and 200 mg/kg. The extract produced a significant (P<0.01) increase in sleeping duration and reduction of onset of sleep compared to sodium thiopental at both doses (200 and 400 mg/kg). The extract (200 and 400 mg/kg) also showed a dose-dependent suppression of motor activity and exploratory activity of the mice in both open field and hole cross test. This study demonstrates that the...

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Research paper thumbnail of Phytochemical, analgesic, antibacterial, and cytotoxic effects of Alpinia nigra (Gaertn.) Burtt leaf extract

Journal of Traditional and Complementary Medicine, 2015

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Research paper thumbnail of Antibacterial Activities of Extracts Obtained from five Important Medicinal Plants of Bangladesh

Editorial Advisory Board e, 2005

... z. 106: 183-185. [3] Anwar, MN, Shing, P., Begum, J. And Choudhury, JU, 1994. ... Bangladesh ... more ... z. 106: 183-185. [3] Anwar, MN, Shing, P., Begum, J. And Choudhury, JU, 1994. ... Bangladesh (Sc.) 12 (1&amp;2) 72-82. [9] Kurian, JC 1995.“Plants That Heal” Oriental Watchman publishing House, Punne, India. [10] Rahman, MS, Anwar, MN, begum, J. and chowdhury, JU, 1997. ...

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Research paper thumbnail of Wild epiphytic Bangladeshi orchids Cymbidium aloifolium (L.) Sw. and Papilionanthe teres (Roxb.) Lindl. potentially modulate the immune functions in Swiss albino mice

Journal of Advanced Veterinary and Animal Research

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Research paper thumbnail of Wild epiphytic Bangladeshi orchids Cymbidium aloifolium (L.) Sw. and Papilionanthe teres (Roxb.) Lindl. potentially modulate the immune functions in Swiss albino mice

This research investigated the immunomodulatory potentials of two medicinally important wild epip... more This research investigated the immunomodulatory potentials of two medicinally important wild epiphytic Bangladeshi orchids Cymbidium aloifolium and Papilionanthe teres using Swiss albino mice. Materials and Methods: Orchid extracts were prepared using a cold methanol extraction procedure. To assess the immunomodulatory action, Swiss albino mice of either sex weighing 25-35 gm were divided into five groups each with six animals. Sheep red blood cells (SRBC) of 0.5 × 10 9 cells/ml were used to immunize all mice on the 7th day, and a booster dose of the same quantity of SRBC was given on the 11th day of the experiment. After 14 days of oral treatment with 100 and 200 mg/kg bw of orchid extract, the mice were sacrificed to collect serum and organs. Hematological assays, delayed type of hypersensitivity assays, phagocytic index (PI), and histopathological investigations were used to assess in vivo immunomodulatory efficacy. Results: The body weight changes of the experimental animals were considerably greater at 100 mg/kg bw than at a higher dose (200 mg/kg bw). There was a substantial improvement of relative organ weights of the thymus and spleen at the low dose, but no effect on kidney weights was evident. The liver weight increased significantly (p < 0.05) at both doses. Total neutrophil, leukocyte, and lymphocyte counts, hemoglobin percentage, delayed hypersensitivity reaction, and PI were all significantly (p < 0.05) increased in mice receiving the lower dose. In contrast to the control group, the higher dose reduced immunological response, suggesting the negative influence of a higher dose of extracts on the immune reaction. Conclusions: The results demonstrate that orchid extracts can potentially modulate the innate immune system in the experimental animal.

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Research paper thumbnail of A Demographic Approach for Understanding the Prevalence of β Thalassemia Patterns and Other Hemoglobinopathies: Selective Study in Chittagong City Perspective

Asian Journal of Biological Sciences, 2013

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Research paper thumbnail of Assessment of antibacterial, thrombolytic and cytotoxic potential of Cassia alata seed oil

Cassia alata is a pan tropical shrub. It has been reported to have medicinal activities like laxa... more Cassia alata is a pan tropical shrub. It has been reported to have medicinal activities like laxative effect and active against ringworm, skin diseases and ulcer. The leaf extract of this plant has shown antibacterial activity. In this study, seed oil extracted from Cassia alata , was studied for Antibacterial, Thrombolytic and Cytotoxic activity by using in vitro techniques. Chloroform extract of the seed oil was tested for Antibacterial activity using disc diffusion method and that extract showed potent antibacterial activity against both Gram(+) and Gram(-) bacteria. DMSO extract of the seed oil was tested for Brine shrimp lethality bioassay using Brine shrimp nauplii. The LC50 of DMSO extract of Cassia alata seed oil was found to be 250µg/ml, indicates that the oil has moderate pharmacological action. The DMSO extract of the seed oil was also tested for in vitro thrombolytic activity. The extract showed reasonable thrombolytic activity against negative control (water).Further in...

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Research paper thumbnail of Root Exudates of Fifteen Common Weed Species: Phytochemical Screening and Allelopathic Effects on T. aestivum L

Agronomy

Through allelopathic interactions, plants may either suppress competing species or promote those ... more Through allelopathic interactions, plants may either suppress competing species or promote those that may help them better adapt to their environment. The purpose of this research was to determine how the root exudates of 15 common weeds affected the germination of wheat (Triticum aestivum L.). Every other day, 15 seeds were dispersed over Petri dishes (with filter paper) and pots (with garden soil) and treated with 1 mL and 5 mL of aqueous root exudates, respectively. Distilled water had the highest germination rate at 86.33% and the lowest at 64.00% (p = 0.001) for Commelina benghalensis in the Petri dish containing root exudates. The seed germination percentage of the pot condition was the lowest, at 68.45% (p = 0.004), for Solanum nigrum, while the control was 87.23%. Similarly, the lowest shoot length, 12.01 cm (p = 0.0025) in Mikania micrantha, and the lowest root length of 2.17 cm (p = 0.0048) in Leucas aspera, were recorded, whereas the control was 19.13 cm and 3.46 cm, resp...

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Research paper thumbnail of Correction: Water hyacinth (Eichhornia crassipes) fractions potentially normalize the lead (Pb) poisoning and enhance in vitro thrombolysis

Advances in Traditional Medicine

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Research paper thumbnail of Edible freshwater snail ( Paludomas conica ) attenuates STZ ‐induced diabetic complications by regulating PFK ‐1 and PON ‐1 gene expression

International Journal of Food Science & Technology

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Research paper thumbnail of Author response for "Edible freshwater snail ( Paludomas conica ) attenuates STZ ‐induced diabetic complications by regulating PFK ‐1 and PON ‐1 gene expression

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Research paper thumbnail of Correction: Rashid et al. Natural Compounds of Lasia spinosa (L.) Stem Potentiate Antidiabetic Actions by Regulating Diabetes and Diabetes-Related Biochemical and Cellular Indexes. Pharmaceuticals 2022, 15, 1466

Pharmaceuticals

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Research paper thumbnail of Natural Compounds of Lasia spinosa (L.) Stem Potentiate Antidiabetic Actions by Regulating Diabetes and Diabetes-Related Biochemical and Cellular Indexes

Pharmaceuticals

Natural biometabolites of plants have been reported to be useful in chronic diseases including di... more Natural biometabolites of plants have been reported to be useful in chronic diseases including diabetes and associated complications. This research is aimed to investigate how the biometabolites of Lasia spinosa methanol stem (MEXLS) extract ameliorative diabetes and diabetes-related complications. MEXLS was examined for in vitro antioxidant and in vivo antidiabetic effects in a streptozotocin-induced diabetes model, and its chemical profiling was done by gas chromatography-mass spectrometry analysis. The results were verified by histopathological examination and in silico ligand-receptor interaction of characterized natural biometabolites with antidiabetic receptor proteins AMPK (PDB ID: 4CFH); PPARγ (PDB ID: 3G9E); and mammalian α-amylase center (PDB ID: 1PPI). The MEXLS was found to show a remarkable α-amylase inhibition (47.45%), strong antioxidant action, and significant (p < 0.05) decrease in blood glucose level, serum aspartate aminotransferase (AST), alanine aminotransfer...

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Research paper thumbnail of Upregulation of Antioxidative Gene Expression by Lasia spinosa Organic Extract Improves the Predisposing Biomarkers and Tissue Architectures in Streptozotocin-Induced Diabetic Models of Long Evans Rats

Antioxidants

Plants are an entity essential to the function of the biosphere as well as human health. In the c... more Plants are an entity essential to the function of the biosphere as well as human health. In the context of human health, this research investigated the effect of Lasia spinosa (Lour) leaf methanolic extracts (LSML) on antioxidative enzymes and gene expression as well as biochemical and histological markers in a streptozotocin (STZ)-induced diabetes model. Fructose-fed streptozotocin (STZ)-induced diabetic animals were subjected to a four-week intervention followed by the assessment of the animal’s blood and tissues for enzymatic, biochemical, histological, and genetic changes. LSML-treated groups were shown to decrease plasma glucose levels and improve body and organ weights compared to the untreated group in a dose-dependent manner. At the doses of 125 and 250 mg/kg b.w., LSML were able to normalize serum, hepatic, and renal biochemical parameters and restore the pancreas, kidney, liver, and spleen tissue architectures to their native state. A considerable increase (p < 0.01) of...

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Research paper thumbnail of Incredible affinity of Kattosh with PPAR‐γ receptors attenuates STZ‐induced pancreas and kidney lesions evidenced in chemicobiological interactions

Journal of Cellular and Molecular Medicine

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Research paper thumbnail of In vitro thrombolytic assay of Alpinia zerumbet, Alpinia nigra and Urena sinuata

ijrpp.pharmascope.org

Atherothrombotic diseases are serious impacts of the thrombus formed in blood vessels. Thrombolyt... more Atherothrombotic diseases are serious impacts of the thrombus formed in blood vessels. Thrombolytic agents are used to dissolve the already formed clots in the blood vessels; but these drugs have certain limitations which can lead to serious and sometimes ...

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Research paper thumbnail of Epiphytic Acampe ochracea orchid relieves paracetamol-induced hepatotoxicity by inhibiting oxidative stress and upregulating antioxidant genes in in vivo and virtual screening

Biomedicine & Pharmacotherapy

Orchids are basically ornamental, and biological functions are seldom evaluated. This research in... more Orchids are basically ornamental, and biological functions are seldom evaluated. This research investigated the effects of Acampe ochracea methanol extract (AOME) in ameliorating the paracetamol (PCM) induced liver injury in Wistar albino rats, evaluating its phytochemical status through UPLC-qTOF-MS analysis. With molecular docking and network pharmacology, virtual screening verified the inevitable interactions between the UPLC-qTOF-MS-characterized compounds and hepatoprotective drug receptors. The AOME has explicit a dose-dependent decrease of liver enzymes acid phosphatase (ACP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), total bilirubin, as well as an increase of serum total protein and antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GSH) with a virtual normalization (p < 0.05-p < 0.001) and the values were almost equivalent to the reference drug silymarin. After pretreatment with AOME, PCM-induced malondialdehyde (MDA) levels were considerably decreased (p < 0.001). Histopathological examinations corroborated the functional and biochemical findings. The AOME upregulated the genes involved in antioxidative (CAT, SOD, β-actin, PON1, and PFK1) and hepatoprotective mechanisms in PCM intoxicated rats. An array of 103 compounds has been identified from AOME through UPLC-qTOF-MS analysis. The detected compounds were substantially related to the targets of several liver proteins and antioxidative enzymes, according to an in silico study. Virtual prediction by SwissADME and admetSAR showed that AOME has drug-like, non-toxic, and potential pharmacological activities in hepatic damage. Furthermore, VEGFA, CYP19A1, MAPK14, ESR1, and PPARG genes interact with target compounds impacting the significant biological actions to recover PCM-induced liver damage.

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Research paper thumbnail of Pretreatment of Blumea lacera leaves ameliorate acute ulcer and oxidative stress in ethanol-induced Long-Evan rat: A combined experimental and chemico-biological interaction

Biomedicine & Pharmacotherapy

Blumea lacera (Burm.f.) DC. is described as a valuable medicinal plant in various popular systems... more Blumea lacera (Burm.f.) DC. is described as a valuable medicinal plant in various popular systems of medicine. The aim of the experiment reports the in vivo antiulcer activity of methanol extract of Blumea lacera (MEBLL) and in silico studies of bioactive constituents of MEBLL. In this study, fasted Long-Evans rat treated with 80 % ethanol (0.5 mL) to induce gastric ulcer, were pretreated orally with MEBLL at different doses (250 and 500 mg/kg, p.o., b.w) and omeprazole (20 mg/kg, p.o.) and distilled water were used as a reference drug and normal control respectively. In silico activity against gastric H+-K+ATPase enzyme was also studied. The findings demonstrated that the treatment with MEBLL attenuated markedly ulcer and protected the integrity of the gastric mucosa by preventing the mucosal ulceration altered biochemical parameters of gastric juice such total carbohydrate, total protein and pepsin activity. Additionally, the experimental groups significantly (p < 0.001) inhibited gastric lesions and malondealdehyde (MDA) levels and upregulated antioxidant enzymes level. Furthermore, nine compounds were documented as bioactive, displayed good binding affinities to against gastric H+-K+ATPase enzyme while these compounds illustrated inhibitory effect. From these studies, it is established MEBLL has ulcer healing property as unveiled by in vivo and in silico studies.

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Research paper thumbnail of Thrombolytic, Cytotoxic and Antidiabetic Effects of Paederia foetida L. Leaf Extract

British Journal of Medicine and Medical Research

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Research paper thumbnail of Water hyacinth (Eichhornia crassipes fractions potentially normalize the lead (Pb) poisoning and enhance in vitro thrombolysis

Oriental Pharmacy and Experimental Medicine, 2016

Water hyacinth (Eichhornia crassipes) has been used in phytoextraction to uptake heavy metals and... more Water hyacinth (Eichhornia crassipes) has been used in phytoextraction to uptake heavy metals and trace elements in various experiments. This research investigated the protective effects of Water hyacinth extracts on Lead (Pb)-induced toxicity in the albino rat. Forty-eight six-weeks-old Wistar albino male rats (average weight, 180 ± 6.45 g) were divided into six groups: normal control (NC), Pb control (PbC), Chloroform extract (ChEx), Ethyl acetate extract (EAEx), Methanol extract (MeEx) and Ascorbic acid treated groups (AA, positive control). All animals except NC group have been administered with Lead acetate (Pb(CH3COOH)2) before the therapeutic dose. Thrombolytic and cytotoxic effects were evaluated by modified clot lysis and Brine shrimp lethality tests respectively. Biochemical analyses reports revealed that ChEx significantly (P ≤ 0.05) reduced the elevated alkaline phosphatase (ALP) and aspartate amino transferase (AST) whereas MeEx did the alanine amino transferase (ALT) in comparison to positive control. ChEx significantly inhibited the Pb deposition in kidney and liver than two other extracts. ChEx significantly increased the liver protein compared to PbC group. In the thrombolytic assay, EAEx showed the pronounced clot lysis (49.24 %) while ChEx and MeEx showed 45.18 % and 29.13 % of clot lysis respectively. In Brine shrimp lethality bioassay, the LC50 value of the ChEx, EAEx and MeEx were 4.16, 4.47 and 9.27 μg/mg respectively and values were statistically significant (p < 0.05) compared to that of reference cytotoxic agent, Vincristine sulfate (LC50’ 0.55). Histopathological screening of kidney, liver and spleen showed that ethyl acetate extract recovered the highest of the cellular damage caused by Lead acetate. Biochemical and histopathological screening, therefore, demonstrate that Water hyacinth could be one of the promising sources of normalizing the Pb-poisoning and enhancing the thrombolysis in an animal model. Therapeutic prospects of Water hyacinth could be further studied through highlighting a dose-response study.

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Research paper thumbnail of Investigation of in vivo neuropharmacological effect of Alpinia nigra leaf extract

Asian Pacific journal of tropical biomedicine, 2014

To analyze in vivo neuro-pharmacological effects of Alpinia nigra as anxiety is a particular form... more To analyze in vivo neuro-pharmacological effects of Alpinia nigra as anxiety is a particular form of behavioral inhibition that occurs in response to novel environmental events. In present study, the extract of Alpinia nigra was evaluated for its central nervous system depressant effect using mice behavioral models, such as hole cross, open field and thiopental sodium induced sleeping time tests for its sedative properties and an elevated plus-maze test for its anxiolytic potential, respectively. In anxiolytic study, the extract displayed increased percentage of entry into open arm at the dose of 400 and 200 mg/kg. The extract produced a significant (P<0.01) increase in sleeping duration and reduction of onset of sleep compared to sodium thiopental at both doses (200 and 400 mg/kg). The extract (200 and 400 mg/kg) also showed a dose-dependent suppression of motor activity and exploratory activity of the mice in both open field and hole cross test. This study demonstrates that the...

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Research paper thumbnail of Phytochemical, analgesic, antibacterial, and cytotoxic effects of Alpinia nigra (Gaertn.) Burtt leaf extract

Journal of Traditional and Complementary Medicine, 2015

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Research paper thumbnail of Antibacterial Activities of Extracts Obtained from five Important Medicinal Plants of Bangladesh

Editorial Advisory Board e, 2005

... z. 106: 183-185. [3] Anwar, MN, Shing, P., Begum, J. And Choudhury, JU, 1994. ... Bangladesh ... more ... z. 106: 183-185. [3] Anwar, MN, Shing, P., Begum, J. And Choudhury, JU, 1994. ... Bangladesh (Sc.) 12 (1&amp;2) 72-82. [9] Kurian, JC 1995.“Plants That Heal” Oriental Watchman publishing House, Punne, India. [10] Rahman, MS, Anwar, MN, begum, J. and chowdhury, JU, 1997. ...

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Research paper thumbnail of Wild epiphytic Bangladeshi orchids Cymbidium aloifolium (L.) Sw. and Papilionanthe teres (Roxb.) Lindl. potentially modulate the immune functions in Swiss albino mice

Journal of Advanced Veterinary and Animal Research

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Research paper thumbnail of Wild epiphytic Bangladeshi orchids Cymbidium aloifolium (L.) Sw. and Papilionanthe teres (Roxb.) Lindl. potentially modulate the immune functions in Swiss albino mice

This research investigated the immunomodulatory potentials of two medicinally important wild epip... more This research investigated the immunomodulatory potentials of two medicinally important wild epiphytic Bangladeshi orchids Cymbidium aloifolium and Papilionanthe teres using Swiss albino mice. Materials and Methods: Orchid extracts were prepared using a cold methanol extraction procedure. To assess the immunomodulatory action, Swiss albino mice of either sex weighing 25-35 gm were divided into five groups each with six animals. Sheep red blood cells (SRBC) of 0.5 × 10 9 cells/ml were used to immunize all mice on the 7th day, and a booster dose of the same quantity of SRBC was given on the 11th day of the experiment. After 14 days of oral treatment with 100 and 200 mg/kg bw of orchid extract, the mice were sacrificed to collect serum and organs. Hematological assays, delayed type of hypersensitivity assays, phagocytic index (PI), and histopathological investigations were used to assess in vivo immunomodulatory efficacy. Results: The body weight changes of the experimental animals were considerably greater at 100 mg/kg bw than at a higher dose (200 mg/kg bw). There was a substantial improvement of relative organ weights of the thymus and spleen at the low dose, but no effect on kidney weights was evident. The liver weight increased significantly (p < 0.05) at both doses. Total neutrophil, leukocyte, and lymphocyte counts, hemoglobin percentage, delayed hypersensitivity reaction, and PI were all significantly (p < 0.05) increased in mice receiving the lower dose. In contrast to the control group, the higher dose reduced immunological response, suggesting the negative influence of a higher dose of extracts on the immune reaction. Conclusions: The results demonstrate that orchid extracts can potentially modulate the innate immune system in the experimental animal.

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Research paper thumbnail of A Demographic Approach for Understanding the Prevalence of β Thalassemia Patterns and Other Hemoglobinopathies: Selective Study in Chittagong City Perspective

Asian Journal of Biological Sciences, 2013

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Research paper thumbnail of Assessment of antibacterial, thrombolytic and cytotoxic potential of Cassia alata seed oil

Cassia alata is a pan tropical shrub. It has been reported to have medicinal activities like laxa... more Cassia alata is a pan tropical shrub. It has been reported to have medicinal activities like laxative effect and active against ringworm, skin diseases and ulcer. The leaf extract of this plant has shown antibacterial activity. In this study, seed oil extracted from Cassia alata , was studied for Antibacterial, Thrombolytic and Cytotoxic activity by using in vitro techniques. Chloroform extract of the seed oil was tested for Antibacterial activity using disc diffusion method and that extract showed potent antibacterial activity against both Gram(+) and Gram(-) bacteria. DMSO extract of the seed oil was tested for Brine shrimp lethality bioassay using Brine shrimp nauplii. The LC50 of DMSO extract of Cassia alata seed oil was found to be 250µg/ml, indicates that the oil has moderate pharmacological action. The DMSO extract of the seed oil was also tested for in vitro thrombolytic activity. The extract showed reasonable thrombolytic activity against negative control (water).Further in...

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