Guy Putet | Uneversité Claude Bernard Lyon 1 (original) (raw)
Papers by Guy Putet
Cahiers d'anesthésiologie, 1994
La digoxine etant un medicament a intervalle therapeutique etroit, les interactions medicamenteus... more La digoxine etant un medicament a intervalle therapeutique etroit, les interactions medicamenteuses peuvent etre dangereuses. Nous rapportons le cas d'un nouveau-ne ayant subi une intoxication a la digoxine apres administration deux jours auparavant d'erythromycine. Plusieurs mecanismes contribuant a accroitre la concentration plasmatique de digoxine peuvent etre mis en cause : inhibition par les macrolides des glycoproteines P de transport, destruction d'une bacterie de la flore intestinale metabolisant la digoxine, augmentation de la vidange gastrique. Une estimation des parametres pharmacocinetiques du patient avant et apres introduction d'erythromycine suggere que l'intoxication serait plutot due a une augmentation de l'absorption digestive de digoxine. Cette observation permet de montrer l'importance et la gravite potentielle de l'interaction medicamenteuse entre la digoxine et l'erythromycine.
Médecine et Maladies Infectieuses
La vancomycine est un antibiotique majeur dans le traitement d‘infections a germes a Gram +, pour... more La vancomycine est un antibiotique majeur dans le traitement d‘infections a germes a Gram +, pour lequel il est necessaire de combiner une efficacite et une non toxicite du traitement. La pharmacie de l‘hopital Debrousse assure le suivi therapeutique de la vancomycine pour le service de reanimation neonatale depuis 5 ans, par l‘adaptation bayesienne des posologies. Une etude retrospective portant sur 145 nouveau‐nes a ete menee avec pour objectif de discuter de l‘interet de l‘adaptation des posologies. Les patients ont ete divises en deux groupes suivant qu‘ils recevaient le traitement en perfusion continue (groupe I) ou en perfusions discontinues (groupe II). Les doses et les concentrations plasmatiques, avant et apres l‘adaptation bayesienne des posologies, ont ete analysees. Les resultats montrent que les posologies, apres la premiere adaptation bayesienne ont ete modifiees pour 71,6 % des patients du groupe I et 90,0 % du groupe II. L‘adaptation bayesienne de posologies a permis d‘augmenter le pourcentage de concentrations plasmatiques de vancomycine situees dans les cibles pour les deux groupes : + 26 % dans le groupe I et + 23 % dans le groupe II. Meme si le suivi therapeutique de la vancomycine ne permet pas dans tous les cas d‘obtenir des concentrations plasmatiques correctes de vancomycine, cette activite est utile pour les patients de reanimation neonatale qui montrent une variabilite pharmacocinetique inter‐ et intra‐individuelle importante, impossible a gerer avec des posologies standards.
Pediatrics, 1982
Energy requirements are partitioned between needs for maintenance (including resting metabolism, ... more Energy requirements are partitioned between needs for maintenance (including resting metabolism, thermoregulation, and muscular activity) and needs for synthesis and storage of new tissue. The partition of energy utilization was evaluated by 22 metabolic and nutritional balance studies in 13 formula-fed (SMA 20/24), growing, appropriate-for-gestational age, very low-birth-weight infants (mean ± SE birth weight, 1,155 ± 39 gm; study weight, 1,271 ± 60 gm; age at study, 21 ± 2 days; weight gain, 16.8 ± 1 gm/kg/day). Continuous opencircuit, indirect calorimetry was performed for periods of 6 ± 0.25 hours in a thermoneutral environment. Results expressed as mean kilocalories per kilogram per day (± SE) were: energy intake, 148.6 (± 3.9); stool and urine losses, 18.2 (± 1.5); metabolizable energy, 130.4 (± 3.5); "basal" metabolic rate, 47.0 (± 0.75); energy cost of activity, 4.3 (± 0.9); thermic effect of food, 11.3 (± 0.65); energy stored in new tissue, 67.8 (± 3.0). These res...
The American Journal of Clinical Nutrition, 1990
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1995
Carbon dioxide emission (VCO2) was computed every 20 min from continuous CO2 concentration record... more Carbon dioxide emission (VCO2) was computed every 20 min from continuous CO2 concentration recordings taken during 3-30 consecutive days, in strictly controlled environmental conditions, in 54 OF1 mice, 99 Japanese quail, 66 Sprague-Dawley rats, 50 Hartley guinea pigs, 7 chicks, for 7-15 days on 2 Cynomolgus monkeys, and for 24 h on 7 premature infants. This VCO2 shows circadian and ultradian oscillations that were analyzed for frequencies and amplitudes in light-dark 12-h alternation (LD 12:12), continuous light (LL), and continuous dark (DD). Circadians were not always identified or were often masked in LL or DD (mostly in guinea pigs, quail, and rats), while ultradians (tau > or = 40 min) were found in all species, at every time, and in all light regimens. Analysis of variance and chi 2 show significant (P < 0.001) interspecies differences for ultradian (1.07 < tau < 1.40 h) intervals and for circadian and ultradian VCO2 amplitudes. Relationships between ultradian and...
The American Journal of Clinical Nutrition, 1992
Net calcium absorption was evaluated in 103 low-birth-weight preterm infants by a 72-h balance te... more Net calcium absorption was evaluated in 103 low-birth-weight preterm infants by a 72-h balance technique. At birth the infants had a mean (+/- SE) gestational age of 30.9 +/- 0.2 wk and weighed 1.43 +/- 0.03 kg. When tested 3 wk later, their net calcium absorption averaged 58 +/- 1% with an intake of 80 +/- 2 mg Ca.kg body wt-1.d-1. Of the 103 infants, 58 had been fed low-birth-weight formulas supplemented with vitamin D. The remainder received banked human milk, of whom 34 were supplemented with vitamin D and calcium; 11 infants received no supplementation. Calcium absorption in the four subgroups did not differ significantly, with neither vitamin D supplementation nor supplementation with vitamin D and calcium affecting percent absorption significantly. Net calcium absorption was a linear function of intake (40-130 mg Ca.kg body wt-1.d-1) with a zero intercept. Because vitamin D supplementation did not increase net calcium absorption, it is concluded that in preterm low-birth-weight infants calcium absorption proceeds by a nonsaturable route, with the transcellular, vitamin D-regulated mechanism not yet expressed.
International Journal of Pediatric Otorhinolaryngology, 1995
In neonates and infants, hearing impairment leads to impaired language and cognitive development.... more In neonates and infants, hearing impairment leads to impaired language and cognitive development. For that reason, early detection of this sensory deficit is of outstanding importance, particularly in pre-term neonates, who constitute a high risk population in regard to very early acquired hearing loss. Evoked (EOAE) and spontaneous otoacoustic emission (SOAE) recording in 93 pre-term and full-term neonates revealed that this technique is potentially useful for auditory screening in neonatology units. EOAEs and SOAEs can be recorded successfully from 30 weeks of conceptional age. SOAEs were found to be prevalent in females and presented higher peak numbers in right than in left ears. Furthermore, SOAE incidence in pre-term and full-term neonates was found to be high in EOAE positive ears, associated with strong and robust EOAEs.
Archives françaises de pédiatrie, 1991
Over a period of 24 years, 23 women who had undergone renal transplantation gave birth to 26 chil... more Over a period of 24 years, 23 women who had undergone renal transplantation gave birth to 26 children whose gestational ages were above 28 weeks. The average duration of stable kidney function tests before the onset of pregnancy was 34.5 months (6 to 109 months). Immunosuppressive treatment consisted mostly of azathioprine and steroids (20/26), steroids and cyclosporin A (CyA) in one case, and azathioprine, steroids and CyA in 5 cases. Average gestational age at birth was 35.2 weeks (30-40 weeks), average birth weight was 2,330 g (1,160-3,700 g). Caesarean section was performed in 73% of cases. The most frequent neonatal pathological condition was the occurrence of respiratory distress, most often related to prematurity and the mode of delivery. No child presented with any lethal congenital malformation. Children born to mothers who were given CyA did not present with more congenital malformations or renal function impairment.
Archives françaises de pédiatrie, 1988
Seventeen premature babies were ventilated with high frequency oscillation (HFO) for severe hyali... more Seventeen premature babies were ventilated with high frequency oscillation (HFO) for severe hyaline membrane disease. The results were compared to a group of 16 babies ventilated with classical positive pressure ventilation and presenting with hyaline membrane disease of the same severity. The results demonstrated an improvement of the mortality rate with HFO without any significant difference of pulmonary or neurologic complications. Furthermore, a controlled study in order to demonstrate an improvement of this type of ventilation is required.
Archives françaises de pédiatrie, 1987
The authors report a controlled study of the use of 2 types of amino-acid solutions for premature... more The authors report a controlled study of the use of 2 types of amino-acid solutions for premature infants nutrition in the first days of life, one of the solution (solution I) being adapted for prematures. The average amino-acid blood levels in prematures receiving solution I were close to those observed in cord blood; Plasma taurine, alanine and arginine concentrations were significantly lower with normalized levels of aromatic amino-acids, lysine, taurine and proline; serum ammonia level was also lower. This study shows that using an amino-acid solution adapted to prematures as a supplement to parenteral nutrition during the first days of life allows to progressively increase the nitrogen intakes without inducing dangerous plasma levels of some amino-acids.
Fetal and Neonatal Physiology, 2004
The Journal of Pediatrics, 1984
Nutrient balance, energy utilization, and composition of weight gain in very-low-birth.weight inf... more Nutrient balance, energy utilization, and composition of weight gain in very-low-birth.weight infants fed pooled human milk or a preterm formula Growth, protein, and energy balances were studied in two groups of very-low-birth-weight premature infants fed pooled pasteurized human milk (HM) or a preterm formula (PF). Each infant was studied at 33 and 36 weeks gestational age with a combined technique of nutrient balance and indirect calorimetry measurement. Weight and length gains were higher with PF than with HM, but head circumference growth was similar with both milks. Although the volume of milk given was lower, energy intake Was higher with PF than with HM in both studies (126 to 130 vs 103 to 109 kcal/kg/day).
The Journal of Pediatrics, 1983
MOST ESTIMATES for fluid replacement therapy in the critically ill newborn infant have been based... more MOST ESTIMATES for fluid replacement therapy in the critically ill newborn infant have been based on the measurement of urine output and data from studies that have determined insensible water loss in well premature infants. TM Several factors make the estimation of insensible
Journal of Pediatric Gastroenterology and Nutrition, 1986
Fat, phosphorus, and calcium balance studies were performed in normal very low birth weight infan... more Fat, phosphorus, and calcium balance studies were performed in normal very low birth weight infants (BW less than or equal to 1,500 g) fed either normal or calcium- and phosphorus-supplemented pooled pasteurized human milk. Calcium and phosphorus supplements were 27 mg/dl and 24.5 mg/dl, respectively, throughout the study. Measured calcium and phosphorus intake in the supplemented group averaged 90 +/- 6 mg/kg/day and 62 mg/kg/day, respectively, compared to 47 +/- 7 mg/kg/day and 24 +/- 6 mg/kg/day in the nonsupplemented group. The percent of fat, calcium, and phosphorus absorption was similar in the two groups: respectively, 71 +/- 23%, 73 +/- 13%, and 93 +/- 2% in the supplemented group compared to 75 +/- 11%, 71 +/- 14%, and 92 +/- 4% in the nonsupplemented group. Calcium and phosphorus retention reached 62 +/- 12 mg/kg/day and 53 +/- 4 mg/kg/day in the supplemented group against 21 +/- 10 mg/kg/day and 21 +/- 5 mg/kg/day in the nonsupplemented group. These data support the notion that calcium, in addition to phosphorus supplementation in pooled human breast milk, improves both calcium and phosphorus retention in preterm infants.
The Journal of Clinical Endocrinology & Metabolism, 1981
A pregnant woman suffering from idiopathic hypoparathyroidism was treated with calcitriol [0.5-2 ... more A pregnant woman suffering from idiopathic hypoparathyroidism was treated with calcitriol [0.5-2 micrograms/day 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3)]. Her twin infants were delivered by cesarian section at 37 weeks of gestation. Laboratory investigations in the perinatal period disclosed: 1) normal serum calcium and phosphorus levels in the mother, 2) normal babies with no clinical or biochemical signs of hyperparathyroidism, 3) a low serum level of 25-hydroxyvitamin D despite a normal serum level of 1,25-(OH)2D in the mother, and 4) a low level of 25-hydroxyvitamin D and a high level of 1,25-(OH)2D in cord serum in both infants. It is suggested that calcitriol is an effective treatment of hypoparathyroidism during pregnancy and produces no ill effects on the baby.
The Journal of Clinical Endocrinology & Metabolism, 1989
Basal plasma GH levels and the GH responses to an injection of 1 microgram/kg 1-44(NH2) GHRH were... more Basal plasma GH levels and the GH responses to an injection of 1 microgram/kg 1-44(NH2) GHRH were determined on day 3 postnatally in 5 small gestational age (SGA) twin newborns and their appropriate gestational age (AGA) co-twins, and in 10 SGA singleton newborns and 6 AGA singleton newborns. The mean basal plasma GH level was higher in the SGA than in the AGA infants but the difference was significant only for singleton newborns (p less than 0.01). The mean peak plasma GH level was markedly increased in SGA compared to AGA infants (p less than 0.05 for twins, p less than 0.01 for singletons). Twelve SGA infants re-tested at 1 month had lower basal and peak plasma GH levels (p less than 0.001 and p less than 0.01). In 21 SGA and 17 AGA infants, serum IGF-I, measured by RIA between 12 and 96 hours after birth, was significantly higher in SGA than in AGA (p less than 0.001). These results suggest that, whatever the mechanism, functional hypersomatotropism is present at day 3 in SGA infants. This hypersomatotropism may participate in the early catch-up growth process.
Hearing Research, 1995
A number of lines of evidence indicate that the human cochlea is fully functional as a mature sou... more A number of lines of evidence indicate that the human cochlea is fully functional as a mature sound transducer by 6 months of age. However, information about the development of the active cochlear mechanisms and notably the development of outer hair cell (OHC) activity is yet incomplete. Recording and analysis of otoacoustic emissions (OAEs), probably generated by the OHCs of the organ of Corti, have led to a better understanding, in humans, of how sounds are analysed in the cochlea by means of active mechanisms. Evoked OAEs (EOAEs) and spontaneous OAEs (SOAEs), when they can be recorded in full-term and preterm neonates, show different characteristics from those in adults, suggesting that maturation of the peripheral auditory system is incomplete at birth. To learn more about this maturation, using the best-established facts concerning SOAEs in adults, such as their greater prevalence in females and also in right ears, SOAEs were studied in more detail in 81 preterm neonates, from 30 to 40 weeks of conceptional age, all presenting bilateral EOAEs according to objective criteria. The first finding of this study was that SOAEs existed and could be recorded as of 30 weeks of conceptional age in humans. Some SOAE characteristics in preterm neonates, such as prevalence, peak number and acoustic frequencies, showed similarity with full-term neonates. Comparison of other criteria between the two populations, such as greater SOAE prevalence in right ears and higher SOAE peak number in females, suggested that these developmental factors emerge around term in humans. Comparison of SOAE characteristics between male and female preterms suggested that male preterms were less advanced in peripheral auditory development than were female preterms.
European Journal of Clinical Microbiology & Infectious Diseases, 2005
Cahiers d'anesthésiologie, 1994
La digoxine etant un medicament a intervalle therapeutique etroit, les interactions medicamenteus... more La digoxine etant un medicament a intervalle therapeutique etroit, les interactions medicamenteuses peuvent etre dangereuses. Nous rapportons le cas d'un nouveau-ne ayant subi une intoxication a la digoxine apres administration deux jours auparavant d'erythromycine. Plusieurs mecanismes contribuant a accroitre la concentration plasmatique de digoxine peuvent etre mis en cause : inhibition par les macrolides des glycoproteines P de transport, destruction d'une bacterie de la flore intestinale metabolisant la digoxine, augmentation de la vidange gastrique. Une estimation des parametres pharmacocinetiques du patient avant et apres introduction d'erythromycine suggere que l'intoxication serait plutot due a une augmentation de l'absorption digestive de digoxine. Cette observation permet de montrer l'importance et la gravite potentielle de l'interaction medicamenteuse entre la digoxine et l'erythromycine.
Médecine et Maladies Infectieuses
La vancomycine est un antibiotique majeur dans le traitement d‘infections a germes a Gram +, pour... more La vancomycine est un antibiotique majeur dans le traitement d‘infections a germes a Gram +, pour lequel il est necessaire de combiner une efficacite et une non toxicite du traitement. La pharmacie de l‘hopital Debrousse assure le suivi therapeutique de la vancomycine pour le service de reanimation neonatale depuis 5 ans, par l‘adaptation bayesienne des posologies. Une etude retrospective portant sur 145 nouveau‐nes a ete menee avec pour objectif de discuter de l‘interet de l‘adaptation des posologies. Les patients ont ete divises en deux groupes suivant qu‘ils recevaient le traitement en perfusion continue (groupe I) ou en perfusions discontinues (groupe II). Les doses et les concentrations plasmatiques, avant et apres l‘adaptation bayesienne des posologies, ont ete analysees. Les resultats montrent que les posologies, apres la premiere adaptation bayesienne ont ete modifiees pour 71,6 % des patients du groupe I et 90,0 % du groupe II. L‘adaptation bayesienne de posologies a permis d‘augmenter le pourcentage de concentrations plasmatiques de vancomycine situees dans les cibles pour les deux groupes : + 26 % dans le groupe I et + 23 % dans le groupe II. Meme si le suivi therapeutique de la vancomycine ne permet pas dans tous les cas d‘obtenir des concentrations plasmatiques correctes de vancomycine, cette activite est utile pour les patients de reanimation neonatale qui montrent une variabilite pharmacocinetique inter‐ et intra‐individuelle importante, impossible a gerer avec des posologies standards.
Pediatrics, 1982
Energy requirements are partitioned between needs for maintenance (including resting metabolism, ... more Energy requirements are partitioned between needs for maintenance (including resting metabolism, thermoregulation, and muscular activity) and needs for synthesis and storage of new tissue. The partition of energy utilization was evaluated by 22 metabolic and nutritional balance studies in 13 formula-fed (SMA 20/24), growing, appropriate-for-gestational age, very low-birth-weight infants (mean ± SE birth weight, 1,155 ± 39 gm; study weight, 1,271 ± 60 gm; age at study, 21 ± 2 days; weight gain, 16.8 ± 1 gm/kg/day). Continuous opencircuit, indirect calorimetry was performed for periods of 6 ± 0.25 hours in a thermoneutral environment. Results expressed as mean kilocalories per kilogram per day (± SE) were: energy intake, 148.6 (± 3.9); stool and urine losses, 18.2 (± 1.5); metabolizable energy, 130.4 (± 3.5); "basal" metabolic rate, 47.0 (± 0.75); energy cost of activity, 4.3 (± 0.9); thermic effect of food, 11.3 (± 0.65); energy stored in new tissue, 67.8 (± 3.0). These res...
The American Journal of Clinical Nutrition, 1990
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1995
Carbon dioxide emission (VCO2) was computed every 20 min from continuous CO2 concentration record... more Carbon dioxide emission (VCO2) was computed every 20 min from continuous CO2 concentration recordings taken during 3-30 consecutive days, in strictly controlled environmental conditions, in 54 OF1 mice, 99 Japanese quail, 66 Sprague-Dawley rats, 50 Hartley guinea pigs, 7 chicks, for 7-15 days on 2 Cynomolgus monkeys, and for 24 h on 7 premature infants. This VCO2 shows circadian and ultradian oscillations that were analyzed for frequencies and amplitudes in light-dark 12-h alternation (LD 12:12), continuous light (LL), and continuous dark (DD). Circadians were not always identified or were often masked in LL or DD (mostly in guinea pigs, quail, and rats), while ultradians (tau > or = 40 min) were found in all species, at every time, and in all light regimens. Analysis of variance and chi 2 show significant (P < 0.001) interspecies differences for ultradian (1.07 < tau < 1.40 h) intervals and for circadian and ultradian VCO2 amplitudes. Relationships between ultradian and...
The American Journal of Clinical Nutrition, 1992
Net calcium absorption was evaluated in 103 low-birth-weight preterm infants by a 72-h balance te... more Net calcium absorption was evaluated in 103 low-birth-weight preterm infants by a 72-h balance technique. At birth the infants had a mean (+/- SE) gestational age of 30.9 +/- 0.2 wk and weighed 1.43 +/- 0.03 kg. When tested 3 wk later, their net calcium absorption averaged 58 +/- 1% with an intake of 80 +/- 2 mg Ca.kg body wt-1.d-1. Of the 103 infants, 58 had been fed low-birth-weight formulas supplemented with vitamin D. The remainder received banked human milk, of whom 34 were supplemented with vitamin D and calcium; 11 infants received no supplementation. Calcium absorption in the four subgroups did not differ significantly, with neither vitamin D supplementation nor supplementation with vitamin D and calcium affecting percent absorption significantly. Net calcium absorption was a linear function of intake (40-130 mg Ca.kg body wt-1.d-1) with a zero intercept. Because vitamin D supplementation did not increase net calcium absorption, it is concluded that in preterm low-birth-weight infants calcium absorption proceeds by a nonsaturable route, with the transcellular, vitamin D-regulated mechanism not yet expressed.
International Journal of Pediatric Otorhinolaryngology, 1995
In neonates and infants, hearing impairment leads to impaired language and cognitive development.... more In neonates and infants, hearing impairment leads to impaired language and cognitive development. For that reason, early detection of this sensory deficit is of outstanding importance, particularly in pre-term neonates, who constitute a high risk population in regard to very early acquired hearing loss. Evoked (EOAE) and spontaneous otoacoustic emission (SOAE) recording in 93 pre-term and full-term neonates revealed that this technique is potentially useful for auditory screening in neonatology units. EOAEs and SOAEs can be recorded successfully from 30 weeks of conceptional age. SOAEs were found to be prevalent in females and presented higher peak numbers in right than in left ears. Furthermore, SOAE incidence in pre-term and full-term neonates was found to be high in EOAE positive ears, associated with strong and robust EOAEs.
Archives françaises de pédiatrie, 1991
Over a period of 24 years, 23 women who had undergone renal transplantation gave birth to 26 chil... more Over a period of 24 years, 23 women who had undergone renal transplantation gave birth to 26 children whose gestational ages were above 28 weeks. The average duration of stable kidney function tests before the onset of pregnancy was 34.5 months (6 to 109 months). Immunosuppressive treatment consisted mostly of azathioprine and steroids (20/26), steroids and cyclosporin A (CyA) in one case, and azathioprine, steroids and CyA in 5 cases. Average gestational age at birth was 35.2 weeks (30-40 weeks), average birth weight was 2,330 g (1,160-3,700 g). Caesarean section was performed in 73% of cases. The most frequent neonatal pathological condition was the occurrence of respiratory distress, most often related to prematurity and the mode of delivery. No child presented with any lethal congenital malformation. Children born to mothers who were given CyA did not present with more congenital malformations or renal function impairment.
Archives françaises de pédiatrie, 1988
Seventeen premature babies were ventilated with high frequency oscillation (HFO) for severe hyali... more Seventeen premature babies were ventilated with high frequency oscillation (HFO) for severe hyaline membrane disease. The results were compared to a group of 16 babies ventilated with classical positive pressure ventilation and presenting with hyaline membrane disease of the same severity. The results demonstrated an improvement of the mortality rate with HFO without any significant difference of pulmonary or neurologic complications. Furthermore, a controlled study in order to demonstrate an improvement of this type of ventilation is required.
Archives françaises de pédiatrie, 1987
The authors report a controlled study of the use of 2 types of amino-acid solutions for premature... more The authors report a controlled study of the use of 2 types of amino-acid solutions for premature infants nutrition in the first days of life, one of the solution (solution I) being adapted for prematures. The average amino-acid blood levels in prematures receiving solution I were close to those observed in cord blood; Plasma taurine, alanine and arginine concentrations were significantly lower with normalized levels of aromatic amino-acids, lysine, taurine and proline; serum ammonia level was also lower. This study shows that using an amino-acid solution adapted to prematures as a supplement to parenteral nutrition during the first days of life allows to progressively increase the nitrogen intakes without inducing dangerous plasma levels of some amino-acids.
Fetal and Neonatal Physiology, 2004
The Journal of Pediatrics, 1984
Nutrient balance, energy utilization, and composition of weight gain in very-low-birth.weight inf... more Nutrient balance, energy utilization, and composition of weight gain in very-low-birth.weight infants fed pooled human milk or a preterm formula Growth, protein, and energy balances were studied in two groups of very-low-birth-weight premature infants fed pooled pasteurized human milk (HM) or a preterm formula (PF). Each infant was studied at 33 and 36 weeks gestational age with a combined technique of nutrient balance and indirect calorimetry measurement. Weight and length gains were higher with PF than with HM, but head circumference growth was similar with both milks. Although the volume of milk given was lower, energy intake Was higher with PF than with HM in both studies (126 to 130 vs 103 to 109 kcal/kg/day).
The Journal of Pediatrics, 1983
MOST ESTIMATES for fluid replacement therapy in the critically ill newborn infant have been based... more MOST ESTIMATES for fluid replacement therapy in the critically ill newborn infant have been based on the measurement of urine output and data from studies that have determined insensible water loss in well premature infants. TM Several factors make the estimation of insensible
Journal of Pediatric Gastroenterology and Nutrition, 1986
Fat, phosphorus, and calcium balance studies were performed in normal very low birth weight infan... more Fat, phosphorus, and calcium balance studies were performed in normal very low birth weight infants (BW less than or equal to 1,500 g) fed either normal or calcium- and phosphorus-supplemented pooled pasteurized human milk. Calcium and phosphorus supplements were 27 mg/dl and 24.5 mg/dl, respectively, throughout the study. Measured calcium and phosphorus intake in the supplemented group averaged 90 +/- 6 mg/kg/day and 62 mg/kg/day, respectively, compared to 47 +/- 7 mg/kg/day and 24 +/- 6 mg/kg/day in the nonsupplemented group. The percent of fat, calcium, and phosphorus absorption was similar in the two groups: respectively, 71 +/- 23%, 73 +/- 13%, and 93 +/- 2% in the supplemented group compared to 75 +/- 11%, 71 +/- 14%, and 92 +/- 4% in the nonsupplemented group. Calcium and phosphorus retention reached 62 +/- 12 mg/kg/day and 53 +/- 4 mg/kg/day in the supplemented group against 21 +/- 10 mg/kg/day and 21 +/- 5 mg/kg/day in the nonsupplemented group. These data support the notion that calcium, in addition to phosphorus supplementation in pooled human breast milk, improves both calcium and phosphorus retention in preterm infants.
The Journal of Clinical Endocrinology & Metabolism, 1981
A pregnant woman suffering from idiopathic hypoparathyroidism was treated with calcitriol [0.5-2 ... more A pregnant woman suffering from idiopathic hypoparathyroidism was treated with calcitriol [0.5-2 micrograms/day 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3)]. Her twin infants were delivered by cesarian section at 37 weeks of gestation. Laboratory investigations in the perinatal period disclosed: 1) normal serum calcium and phosphorus levels in the mother, 2) normal babies with no clinical or biochemical signs of hyperparathyroidism, 3) a low serum level of 25-hydroxyvitamin D despite a normal serum level of 1,25-(OH)2D in the mother, and 4) a low level of 25-hydroxyvitamin D and a high level of 1,25-(OH)2D in cord serum in both infants. It is suggested that calcitriol is an effective treatment of hypoparathyroidism during pregnancy and produces no ill effects on the baby.
The Journal of Clinical Endocrinology & Metabolism, 1989
Basal plasma GH levels and the GH responses to an injection of 1 microgram/kg 1-44(NH2) GHRH were... more Basal plasma GH levels and the GH responses to an injection of 1 microgram/kg 1-44(NH2) GHRH were determined on day 3 postnatally in 5 small gestational age (SGA) twin newborns and their appropriate gestational age (AGA) co-twins, and in 10 SGA singleton newborns and 6 AGA singleton newborns. The mean basal plasma GH level was higher in the SGA than in the AGA infants but the difference was significant only for singleton newborns (p less than 0.01). The mean peak plasma GH level was markedly increased in SGA compared to AGA infants (p less than 0.05 for twins, p less than 0.01 for singletons). Twelve SGA infants re-tested at 1 month had lower basal and peak plasma GH levels (p less than 0.001 and p less than 0.01). In 21 SGA and 17 AGA infants, serum IGF-I, measured by RIA between 12 and 96 hours after birth, was significantly higher in SGA than in AGA (p less than 0.001). These results suggest that, whatever the mechanism, functional hypersomatotropism is present at day 3 in SGA infants. This hypersomatotropism may participate in the early catch-up growth process.
Hearing Research, 1995
A number of lines of evidence indicate that the human cochlea is fully functional as a mature sou... more A number of lines of evidence indicate that the human cochlea is fully functional as a mature sound transducer by 6 months of age. However, information about the development of the active cochlear mechanisms and notably the development of outer hair cell (OHC) activity is yet incomplete. Recording and analysis of otoacoustic emissions (OAEs), probably generated by the OHCs of the organ of Corti, have led to a better understanding, in humans, of how sounds are analysed in the cochlea by means of active mechanisms. Evoked OAEs (EOAEs) and spontaneous OAEs (SOAEs), when they can be recorded in full-term and preterm neonates, show different characteristics from those in adults, suggesting that maturation of the peripheral auditory system is incomplete at birth. To learn more about this maturation, using the best-established facts concerning SOAEs in adults, such as their greater prevalence in females and also in right ears, SOAEs were studied in more detail in 81 preterm neonates, from 30 to 40 weeks of conceptional age, all presenting bilateral EOAEs according to objective criteria. The first finding of this study was that SOAEs existed and could be recorded as of 30 weeks of conceptional age in humans. Some SOAE characteristics in preterm neonates, such as prevalence, peak number and acoustic frequencies, showed similarity with full-term neonates. Comparison of other criteria between the two populations, such as greater SOAE prevalence in right ears and higher SOAE peak number in females, suggested that these developmental factors emerge around term in humans. Comparison of SOAE characteristics between male and female preterms suggested that male preterms were less advanced in peripheral auditory development than were female preterms.
European Journal of Clinical Microbiology & Infectious Diseases, 2005