keskanya subbalekha | Chulalongkorn University (original) (raw)
Papers by keskanya subbalekha
Clinical Oral Implants Research
ObjectiveThis scoping review aimed to (1) critically evaluate the outcomes measures used to asses... more ObjectiveThis scoping review aimed to (1) critically evaluate the outcomes measures used to assess the accuracy of implant placement with Computer Assisted Implant Surgery (CAIS) and (2) review the evidence supporting the efficient implementation of CAIS in training and education of clinicians.MethodsA scoping literature review was conducted aiming to identify (a) clinical trials assessing accuracy of implant placement with CAIS, and (b) clinical trials or simulation/cadaver studies where CAIS was utilised and assessed for the training/education of clinicians. Studies since 1995 were assessed for suitability and data related to the outcomes measures of accuracy and educational efficacy were extracted and synthesised.ResultsAccuracy of CAIS has been mainly assessed through surrogate measures. Individual clinical trials have not shown any difference between static and dynamic CAIS, but recent meta‐analyses suggest an advantage of dynamic CAIS in reducing angular deviation. The combina...
Journal of Periodontal Research, Jan 11, 2016
Background and ObjectiveNotch signaling regulates bone homeostasis. The present study investigate... more Background and ObjectiveNotch signaling regulates bone homeostasis. The present study investigated the effect of Jagged1 on osteoprotegerin (OPG) and receptor activator of nuclear factor kappa‐B ligand (RANKL) expression in human periodontal ligament stromal (hPDL) cells.Material and MethodshPDL cells were seeded on to indirect immobilized Jagged1 surfaces. OPG expression was determined using real‐time polymerase chain reaction and enzyme‐linked immunosorbent assay. Lentiviral small hairpin RNA particles against NOTCH2 were employed to inhibit NOTCH2 expression. Osteoclast formation was evaluated using RAW264.7 cells. An influence of exogenous OPG on osteogenic differentiation was determined by real‐time polymerase chain reaction and Alizarin Red S staining.ResultsJagged1 significantly enhanced HES1 and HEY1mRNA expression in a dose‐dependent manner. Furthermore, OPG mRNA and protein levels dramatically decreased upon exposing hPDL cells to Jagged1. However, RANKL mRNA levels were not significantly different. There was also no difference in M‐CSF and MCP‐1mRNA expression. A γ‐secretase inhibitor and cycloheximide treatment rescued Jagged1‐attenuated OPG expression. Furthermore, shNOTCH2 overexpressing hPDL cells did not exhibit a decrease in OPG expression upon exposure to Jagged1, implying the involvement of NOTCH2 in the regulatory mechanism. Culturing RAW264.7 cells with conditioned medium from Jagged1‐treated hPDL cells enhanced osteoclast formation compared with those cultured with conditioned medium of the control group. Lastly, OPG treatment did not influence osteogenic differentiation by hPDL cells.ConclusionThese results suggest that Jagged1 activates Notch signaling in hPDL cells, leading to decreased OPG expression. This may imply an indirect role of Jagged1 on the regulation of osteoclast differentiation via hPDL cells.
Clinical Implant Dentistry and Related Research, Jan 11, 2023
PurposeThe aim of this study was to investigate the effects of deproteinized bovine bone (DBB, Bi... more PurposeThe aim of this study was to investigate the effects of deproteinized bovine bone (DBB, Bio‐Oss®) and freeze‐dried bone allograft (FDBA, SureOss®) on bone healing during maxillary sinus floor augmentation (MSFA) using histology, immunohistochemistry, and gene expressions of the marker genes including Runx2, Opn, Ocn, Col1a1, Rankl, and Tnf‐α.Materials and MethodsFourteen participants who required two‐stage maxillary sinus augmentation were randomly assigned to DBB and FDBA bone grafting groups. Six months after the sinus augmentation procedure, bone samples were collected before implant placement with a trephine bur. Gene expression of Runx2, Opn, Ocn, Col1a1, Rankl, and Tnf‐α of the bone samples was assessed by real‐time polymerase chain reaction as a primary outcome. Histological analysis of H&E‐stained sections, immunohistochemistry for OPN quantification, and CBCT‐based bone tissue examination were performed to investigate the bone healing effects of DBB and FDBA substitutes.ResultsThe FDBA treated group showed higher gene expression when compared with the DBB treated group in Opn (2.83 ± 1.23 vs. 1.40 ± 0.69; p = 0.04), Runx2 (1.49 ± 0.44 vs. 0.67 ± 0.14; p = 0.01), and Rankl (2.34 ± 0.85 vs. 0.69 ± 0.39; p = 0.03). In the DBB treated group a downregulated expression was found of Ocn relative to maxillary edentulous bone (1.18 ± 0.40 vs. 2.51 ± 0.78; p = 0.02).ConclusionTwo‐stage maxillary sinus augmentation with FDBA upregulated specific bone remodeling genes when compared to DBB. The outcome of gene expression matched with the ones for OPN immunoreactivity, being higher in the FDBA group. FDBA had an expression pattern similar to native bone and showed stronger expression of bone forming related‐genes suggesting it may be clinically preferable over DBB.This clinical trial was not registered prior to participant recruitment and randomization (clinical registration number TCTR20221217002).
Hno, Jun 1, 2015
Eine 26-jährige Frau stellte sichmit einer über mehrere Monate rezidivierenden, unilateralen Sinu... more Eine 26-jährige Frau stellte sichmit einer über mehrere Monate rezidivierenden, unilateralen Sinusitis maxillaris rechts in einer kieferchirurgischen Klinik vor. Die Beschwerden traten intermittierend auf und äußerten sich in unilateralen infraorbitalen Schmerzen und zeitweiliger Absonderung von trübem Nasensekret. Konservative Behandlungen einschließlich einerAntibiotikatherapie erbrachten keine Besserung. Anamnestisch war die operative Entfernung eines retinierten und impaktierten Weisheitszahnes im Bereich des Oberkiefers rechts (18) in einer oralchirurgischen Praxis vor sechs Monaten durchgeführt worden. Dieser Eingriff erfolgte nach Angaben der Patientin ohne Komplikationen. Nebenerkrankungen waren nicht bekannt.
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Jul 1, 2021
Abstract Objective To investigate effect of platelet-rich fibrin (PRF) on bone regeneration in re... more Abstract Objective To investigate effect of platelet-rich fibrin (PRF) on bone regeneration in repairing alveolar clefts with autologous particulate cancellous bone and marrow (PCBM) from iliac crest. Methods Alveolar cleft patients were randomly divided into the PRF group (mixing PCBM with liquid PRF and covering the graft with PRF membranes) or control group (PCBM only). After bone graft, the regenerated bone volume was assessed by cone beam computed tomography (CBCT) at 6 months, the bone density was evaluated by CBCT at 6 months and periapical radiographs at 1, 3, and 6 months. The position of the regenerated bone at 6-months was classified using the Chelsea scale. The Mann-Whitney U test was used to analyze differences in bone volume and density between groups. Results Fifteen alveolar cleft sites (13 patients, aged 8–14 years old) were analyzed. The PRF and control group consisted of 8 and 7 cleft sites, respectively. The regenerated bone volume and density were not significantly different between both groups. The Chelsea scale results were similar in both groups. All clefts healed uneventfully. Conclusions PRF did not affect bone regeneration when repairing alveolar clefts with autologous PCBM.
PubMed, 2022
Background: Reconstruction of the helical upper-third is often technically demanding, especially ... more Background: Reconstruction of the helical upper-third is often technically demanding, especially when the defect is huge and the ear is severely deformed. The aim of this short communication was to present an alternative technique to rebuild this difficult task, using a modification of the Bardach's three-legged rotation flap for scalp closure. Methods: To achieve the flap design, we raised the retro- and supraauricular tissue with the Dieffenbach's postauricular advancement fl ap. The Gillies' V-Y advancement fl ap helped to develop the preauricular fl ap, and the Mustardé's otoplastik technique was used to reduce the gap between the resected ear cartilage and the temple. Conclusion: This flap technique appears simple and quick; thereby, it can be used as a single-staged reconstruction alternative in aging patients with multiple comorbidities.
Surgical Oncology-oxford, Sep 1, 2022
Korean Journal of Family Medicine, Jan 20, 2023
Patients with angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema (ACEIIA) may visi... more Patients with angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema (ACEIIA) may visit family physicians. The aim of this article was to describe a case of delayed-onset ACEIIA and to present a concise scoping review. Using a case report and a scoping review study design, we report a case of ACEIIA, with clinically confirmed diagnosis. The symptoms resolved after replacing the offending ACEI with another antihypertensive agent. After excluding other causes of perioral swelling and discontinuation of ACEI, the patient was symptom-free within a few days thereafter. Based on this case presentation, we performed a meta-narrative scoping review including up-todate diagnosis and management of ACEIIA, based on published data in English, French, and German from inception to April 1, 2021. Patients with angioedema of unknown origin should be cautiously examined to rule out oral diseases, including allergy to dental materials and drug-induced angioedema. Clinicopathological aspects and current treatment guidelines for ACEI-associated angioedema are also presented.
International Journal of Oral and Maxillofacial Surgery, Feb 1, 2023
Clinical Implant Dentistry and Related Research, Jul 7, 2021
ObjectiveThe purpose of this study was to compare patient‐reported outcomes and experiences (PROs... more ObjectiveThe purpose of this study was to compare patient‐reported outcomes and experiences (PROs and PREs) among three techniques of dental implant placement, including (a) conventional freehand, (b) dynamic, and (c) static computer‐aided implant surgery (CAIS).Material and methodsNinety patients were randomly assigned to have dental implant placed with one of the three protocols. Participants were asked to fill in a series of self‐administered questionnaires assessing (1) preoperative expectations, (2) postoperative healing events during the first week after surgery, and (3) experiences and overall satisfaction with the procedures at 2 weeks. Differences within the groups were analyzed by Wilcoxson signed‐rank test. Kruskal–Wallis test was used for comparisons among the three groups.ResultsEighty‐eight patients completed the study. Patients' expectations on chewing difficulty, the postoperative experience of duration of pain, speaking limitations, and impact on routine activities were significantly different among groups (p = 0.04, 0.01, 0.038, and 0.046, respectively). Overall, patients appeared to significantly underestimate the duration of postoperative pain (p = 0.035) and swelling (p = 0.001). No significant difference in magnitude of postoperative pain, swelling, and painkiller consumption was found among the groups. The short‐term functional limitations after surgery were deemed acceptable by most participants and 89% were satisfied by the overall procedure.ConclusionsSurgical placement of dental implant with conventional freehand, static, and dynamic CAIS techniques did not result in any difference in the level of postoperative pain and swelling, and appeared to lead to equal levels of satisfaction as expressed by the patients postoperatively.
Journal of Stomatology, Oral and Maxillofacial Surgery
International Journal of Oral and Maxillofacial Surgery
International Journal of Oral and Maxillofacial Surgery, 2019
Please cite this article in press as: Kiatkroekkrai P, et al. Accuracy of implant position when p... more Please cite this article in press as: Kiatkroekkrai P, et al. Accuracy of implant position when placed using static computer-assisted implant surgical guides manufactured with two different optical scanning techniques: a randomized clinical trial, Int J Oral Maxillofac Randomised Clinical Trial Dental Implants
Journal of Stomatology, Oral and Maxillofacial Surgery, 2017
A 27-year-old black woman presented for the diagnosis and management of a painless mass affixed a... more A 27-year-old black woman presented for the diagnosis and management of a painless mass affixed at the gum lying over her right upper central incisor. She first noticed the swelling approximately 3 months ago, but could not recall any trauma to the area. The patient's medical history was unremarkable, except for an allergy to antimicrobial quinolones. Clinical examination revealed a well-defined gum mass located in the area of tooth n o 11, covered by normal mucosa. The lesion measured approximately 2 Â 2 cm, firm on palpation and painless (Fig. 1). There was no associated facial deformity or skin lesion, and no cervical mass or lymphadenopathy was found. Laboratory blood examination was within normal limits. Radiographically, there was no bone abnormality. An excisional biopsy was performed under local anaesthesia. The mass was non-encapsulated. The specimen measured 15 Â 12 Â 5 mm. Histopathologic examination showed a lobulated tumour composed of haphazardly arranged stellate and spindleshaped cells in a myxoid stroma interspersed with variable amounts of collagen fibres. Islets of odontogenic epithelium were also present (Fig. 2).
Journal of Stomatology, Oral and Maxillofacial Surgery
Journal of Stomatology, Oral and Maxillofacial Surgery
Journal of Maxillofacial and Oral Surgery
Objectives To examine outcomes of the coronal scalp approach to craniomaxillofacial (CMF) fractur... more Objectives To examine outcomes of the coronal scalp approach to craniomaxillofacial (CMF) fractures performed by oral-maxillofacial or craniofacial plastic surgery residents (OMFS/CFPS-Rs) vs. trauma surgery residents (TS-Rs), and to determine differences in treatment outcomes between both operator groups. Methods This retrospective cohort study enrolled a sample of CMF fracture adult patients treated via the coronal approach in a German level one trauma center during a two-year interval. The predictor variable was training background (OMFS/CFPS-Rs vs. TS-Rs; each n = 5). All trainees must assist in ≥ two surgeries before self-performance. The main outcomes were length of hospital stay (LHS) and coronal flap-related complications (CFRCs). Appropriate statistics were computed at α = 95%. Results Of the 97 patients identified during the study period; 71 of whom (19.7% females; mean age, 40.2 ± 15.2 years; 46.5% operated by TS-Rs; 38% combined upper and midfacial fractures) met the inc...
Journal of Cutaneous Medicine and Surgery
Purpose To answer the following clinical research question: “Among patients with multiple basal c... more Purpose To answer the following clinical research question: “Among patients with multiple basal cell carcinomas (mBCCs), can panoramic radiograph (PaR) facilitate the diagnosis of Gorlin-Goltz syndrome (GGS)?” Methods This retrospective study enrolled mBCCs subjects who presented to a German tertiary care center between 1 January 2015 and 31 December 2021. The primary predictor was presence of syndromic mBCCs, and the main outcomes were jaw cysts and odontogenic keratocysts (OKCs). Descriptive, bi- and multivariate statistics, diagnostic test evaluation, and number needed to screen (NNS) were computed at α = 95%. Results The sample comprised 527 mBCCs patients (36.1% females; 6.8% GGS; 5.5% OKCs; mean age, 74.5 ± 15.8 years [range, 15-102]). There was a significant association between syndromic mBCCs and jaw cysts ( P < .0001; NNS = 2 [95% CI, CI, 1.1 to 1.4]). In the adjusted logistic model, PaR identified GGS via radiographic diagnosis of jaw cysts in case of 1) age ≤ 35 years,...
Clinical Oral Implants Research
ObjectiveThis scoping review aimed to (1) critically evaluate the outcomes measures used to asses... more ObjectiveThis scoping review aimed to (1) critically evaluate the outcomes measures used to assess the accuracy of implant placement with Computer Assisted Implant Surgery (CAIS) and (2) review the evidence supporting the efficient implementation of CAIS in training and education of clinicians.MethodsA scoping literature review was conducted aiming to identify (a) clinical trials assessing accuracy of implant placement with CAIS, and (b) clinical trials or simulation/cadaver studies where CAIS was utilised and assessed for the training/education of clinicians. Studies since 1995 were assessed for suitability and data related to the outcomes measures of accuracy and educational efficacy were extracted and synthesised.ResultsAccuracy of CAIS has been mainly assessed through surrogate measures. Individual clinical trials have not shown any difference between static and dynamic CAIS, but recent meta‐analyses suggest an advantage of dynamic CAIS in reducing angular deviation. The combina...
Journal of Periodontal Research, Jan 11, 2016
Background and ObjectiveNotch signaling regulates bone homeostasis. The present study investigate... more Background and ObjectiveNotch signaling regulates bone homeostasis. The present study investigated the effect of Jagged1 on osteoprotegerin (OPG) and receptor activator of nuclear factor kappa‐B ligand (RANKL) expression in human periodontal ligament stromal (hPDL) cells.Material and MethodshPDL cells were seeded on to indirect immobilized Jagged1 surfaces. OPG expression was determined using real‐time polymerase chain reaction and enzyme‐linked immunosorbent assay. Lentiviral small hairpin RNA particles against NOTCH2 were employed to inhibit NOTCH2 expression. Osteoclast formation was evaluated using RAW264.7 cells. An influence of exogenous OPG on osteogenic differentiation was determined by real‐time polymerase chain reaction and Alizarin Red S staining.ResultsJagged1 significantly enhanced HES1 and HEY1mRNA expression in a dose‐dependent manner. Furthermore, OPG mRNA and protein levels dramatically decreased upon exposing hPDL cells to Jagged1. However, RANKL mRNA levels were not significantly different. There was also no difference in M‐CSF and MCP‐1mRNA expression. A γ‐secretase inhibitor and cycloheximide treatment rescued Jagged1‐attenuated OPG expression. Furthermore, shNOTCH2 overexpressing hPDL cells did not exhibit a decrease in OPG expression upon exposure to Jagged1, implying the involvement of NOTCH2 in the regulatory mechanism. Culturing RAW264.7 cells with conditioned medium from Jagged1‐treated hPDL cells enhanced osteoclast formation compared with those cultured with conditioned medium of the control group. Lastly, OPG treatment did not influence osteogenic differentiation by hPDL cells.ConclusionThese results suggest that Jagged1 activates Notch signaling in hPDL cells, leading to decreased OPG expression. This may imply an indirect role of Jagged1 on the regulation of osteoclast differentiation via hPDL cells.
Clinical Implant Dentistry and Related Research, Jan 11, 2023
PurposeThe aim of this study was to investigate the effects of deproteinized bovine bone (DBB, Bi... more PurposeThe aim of this study was to investigate the effects of deproteinized bovine bone (DBB, Bio‐Oss®) and freeze‐dried bone allograft (FDBA, SureOss®) on bone healing during maxillary sinus floor augmentation (MSFA) using histology, immunohistochemistry, and gene expressions of the marker genes including Runx2, Opn, Ocn, Col1a1, Rankl, and Tnf‐α.Materials and MethodsFourteen participants who required two‐stage maxillary sinus augmentation were randomly assigned to DBB and FDBA bone grafting groups. Six months after the sinus augmentation procedure, bone samples were collected before implant placement with a trephine bur. Gene expression of Runx2, Opn, Ocn, Col1a1, Rankl, and Tnf‐α of the bone samples was assessed by real‐time polymerase chain reaction as a primary outcome. Histological analysis of H&E‐stained sections, immunohistochemistry for OPN quantification, and CBCT‐based bone tissue examination were performed to investigate the bone healing effects of DBB and FDBA substitutes.ResultsThe FDBA treated group showed higher gene expression when compared with the DBB treated group in Opn (2.83 ± 1.23 vs. 1.40 ± 0.69; p = 0.04), Runx2 (1.49 ± 0.44 vs. 0.67 ± 0.14; p = 0.01), and Rankl (2.34 ± 0.85 vs. 0.69 ± 0.39; p = 0.03). In the DBB treated group a downregulated expression was found of Ocn relative to maxillary edentulous bone (1.18 ± 0.40 vs. 2.51 ± 0.78; p = 0.02).ConclusionTwo‐stage maxillary sinus augmentation with FDBA upregulated specific bone remodeling genes when compared to DBB. The outcome of gene expression matched with the ones for OPN immunoreactivity, being higher in the FDBA group. FDBA had an expression pattern similar to native bone and showed stronger expression of bone forming related‐genes suggesting it may be clinically preferable over DBB.This clinical trial was not registered prior to participant recruitment and randomization (clinical registration number TCTR20221217002).
Hno, Jun 1, 2015
Eine 26-jährige Frau stellte sichmit einer über mehrere Monate rezidivierenden, unilateralen Sinu... more Eine 26-jährige Frau stellte sichmit einer über mehrere Monate rezidivierenden, unilateralen Sinusitis maxillaris rechts in einer kieferchirurgischen Klinik vor. Die Beschwerden traten intermittierend auf und äußerten sich in unilateralen infraorbitalen Schmerzen und zeitweiliger Absonderung von trübem Nasensekret. Konservative Behandlungen einschließlich einerAntibiotikatherapie erbrachten keine Besserung. Anamnestisch war die operative Entfernung eines retinierten und impaktierten Weisheitszahnes im Bereich des Oberkiefers rechts (18) in einer oralchirurgischen Praxis vor sechs Monaten durchgeführt worden. Dieser Eingriff erfolgte nach Angaben der Patientin ohne Komplikationen. Nebenerkrankungen waren nicht bekannt.
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Jul 1, 2021
Abstract Objective To investigate effect of platelet-rich fibrin (PRF) on bone regeneration in re... more Abstract Objective To investigate effect of platelet-rich fibrin (PRF) on bone regeneration in repairing alveolar clefts with autologous particulate cancellous bone and marrow (PCBM) from iliac crest. Methods Alveolar cleft patients were randomly divided into the PRF group (mixing PCBM with liquid PRF and covering the graft with PRF membranes) or control group (PCBM only). After bone graft, the regenerated bone volume was assessed by cone beam computed tomography (CBCT) at 6 months, the bone density was evaluated by CBCT at 6 months and periapical radiographs at 1, 3, and 6 months. The position of the regenerated bone at 6-months was classified using the Chelsea scale. The Mann-Whitney U test was used to analyze differences in bone volume and density between groups. Results Fifteen alveolar cleft sites (13 patients, aged 8–14 years old) were analyzed. The PRF and control group consisted of 8 and 7 cleft sites, respectively. The regenerated bone volume and density were not significantly different between both groups. The Chelsea scale results were similar in both groups. All clefts healed uneventfully. Conclusions PRF did not affect bone regeneration when repairing alveolar clefts with autologous PCBM.
PubMed, 2022
Background: Reconstruction of the helical upper-third is often technically demanding, especially ... more Background: Reconstruction of the helical upper-third is often technically demanding, especially when the defect is huge and the ear is severely deformed. The aim of this short communication was to present an alternative technique to rebuild this difficult task, using a modification of the Bardach's three-legged rotation flap for scalp closure. Methods: To achieve the flap design, we raised the retro- and supraauricular tissue with the Dieffenbach's postauricular advancement fl ap. The Gillies' V-Y advancement fl ap helped to develop the preauricular fl ap, and the Mustardé's otoplastik technique was used to reduce the gap between the resected ear cartilage and the temple. Conclusion: This flap technique appears simple and quick; thereby, it can be used as a single-staged reconstruction alternative in aging patients with multiple comorbidities.
Surgical Oncology-oxford, Sep 1, 2022
Korean Journal of Family Medicine, Jan 20, 2023
Patients with angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema (ACEIIA) may visi... more Patients with angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema (ACEIIA) may visit family physicians. The aim of this article was to describe a case of delayed-onset ACEIIA and to present a concise scoping review. Using a case report and a scoping review study design, we report a case of ACEIIA, with clinically confirmed diagnosis. The symptoms resolved after replacing the offending ACEI with another antihypertensive agent. After excluding other causes of perioral swelling and discontinuation of ACEI, the patient was symptom-free within a few days thereafter. Based on this case presentation, we performed a meta-narrative scoping review including up-todate diagnosis and management of ACEIIA, based on published data in English, French, and German from inception to April 1, 2021. Patients with angioedema of unknown origin should be cautiously examined to rule out oral diseases, including allergy to dental materials and drug-induced angioedema. Clinicopathological aspects and current treatment guidelines for ACEI-associated angioedema are also presented.
International Journal of Oral and Maxillofacial Surgery, Feb 1, 2023
Clinical Implant Dentistry and Related Research, Jul 7, 2021
ObjectiveThe purpose of this study was to compare patient‐reported outcomes and experiences (PROs... more ObjectiveThe purpose of this study was to compare patient‐reported outcomes and experiences (PROs and PREs) among three techniques of dental implant placement, including (a) conventional freehand, (b) dynamic, and (c) static computer‐aided implant surgery (CAIS).Material and methodsNinety patients were randomly assigned to have dental implant placed with one of the three protocols. Participants were asked to fill in a series of self‐administered questionnaires assessing (1) preoperative expectations, (2) postoperative healing events during the first week after surgery, and (3) experiences and overall satisfaction with the procedures at 2 weeks. Differences within the groups were analyzed by Wilcoxson signed‐rank test. Kruskal–Wallis test was used for comparisons among the three groups.ResultsEighty‐eight patients completed the study. Patients' expectations on chewing difficulty, the postoperative experience of duration of pain, speaking limitations, and impact on routine activities were significantly different among groups (p = 0.04, 0.01, 0.038, and 0.046, respectively). Overall, patients appeared to significantly underestimate the duration of postoperative pain (p = 0.035) and swelling (p = 0.001). No significant difference in magnitude of postoperative pain, swelling, and painkiller consumption was found among the groups. The short‐term functional limitations after surgery were deemed acceptable by most participants and 89% were satisfied by the overall procedure.ConclusionsSurgical placement of dental implant with conventional freehand, static, and dynamic CAIS techniques did not result in any difference in the level of postoperative pain and swelling, and appeared to lead to equal levels of satisfaction as expressed by the patients postoperatively.
Journal of Stomatology, Oral and Maxillofacial Surgery
International Journal of Oral and Maxillofacial Surgery
International Journal of Oral and Maxillofacial Surgery, 2019
Please cite this article in press as: Kiatkroekkrai P, et al. Accuracy of implant position when p... more Please cite this article in press as: Kiatkroekkrai P, et al. Accuracy of implant position when placed using static computer-assisted implant surgical guides manufactured with two different optical scanning techniques: a randomized clinical trial, Int J Oral Maxillofac Randomised Clinical Trial Dental Implants
Journal of Stomatology, Oral and Maxillofacial Surgery, 2017
A 27-year-old black woman presented for the diagnosis and management of a painless mass affixed a... more A 27-year-old black woman presented for the diagnosis and management of a painless mass affixed at the gum lying over her right upper central incisor. She first noticed the swelling approximately 3 months ago, but could not recall any trauma to the area. The patient's medical history was unremarkable, except for an allergy to antimicrobial quinolones. Clinical examination revealed a well-defined gum mass located in the area of tooth n o 11, covered by normal mucosa. The lesion measured approximately 2 Â 2 cm, firm on palpation and painless (Fig. 1). There was no associated facial deformity or skin lesion, and no cervical mass or lymphadenopathy was found. Laboratory blood examination was within normal limits. Radiographically, there was no bone abnormality. An excisional biopsy was performed under local anaesthesia. The mass was non-encapsulated. The specimen measured 15 Â 12 Â 5 mm. Histopathologic examination showed a lobulated tumour composed of haphazardly arranged stellate and spindleshaped cells in a myxoid stroma interspersed with variable amounts of collagen fibres. Islets of odontogenic epithelium were also present (Fig. 2).
Journal of Stomatology, Oral and Maxillofacial Surgery
Journal of Stomatology, Oral and Maxillofacial Surgery
Journal of Maxillofacial and Oral Surgery
Objectives To examine outcomes of the coronal scalp approach to craniomaxillofacial (CMF) fractur... more Objectives To examine outcomes of the coronal scalp approach to craniomaxillofacial (CMF) fractures performed by oral-maxillofacial or craniofacial plastic surgery residents (OMFS/CFPS-Rs) vs. trauma surgery residents (TS-Rs), and to determine differences in treatment outcomes between both operator groups. Methods This retrospective cohort study enrolled a sample of CMF fracture adult patients treated via the coronal approach in a German level one trauma center during a two-year interval. The predictor variable was training background (OMFS/CFPS-Rs vs. TS-Rs; each n = 5). All trainees must assist in ≥ two surgeries before self-performance. The main outcomes were length of hospital stay (LHS) and coronal flap-related complications (CFRCs). Appropriate statistics were computed at α = 95%. Results Of the 97 patients identified during the study period; 71 of whom (19.7% females; mean age, 40.2 ± 15.2 years; 46.5% operated by TS-Rs; 38% combined upper and midfacial fractures) met the inc...
Journal of Cutaneous Medicine and Surgery
Purpose To answer the following clinical research question: “Among patients with multiple basal c... more Purpose To answer the following clinical research question: “Among patients with multiple basal cell carcinomas (mBCCs), can panoramic radiograph (PaR) facilitate the diagnosis of Gorlin-Goltz syndrome (GGS)?” Methods This retrospective study enrolled mBCCs subjects who presented to a German tertiary care center between 1 January 2015 and 31 December 2021. The primary predictor was presence of syndromic mBCCs, and the main outcomes were jaw cysts and odontogenic keratocysts (OKCs). Descriptive, bi- and multivariate statistics, diagnostic test evaluation, and number needed to screen (NNS) were computed at α = 95%. Results The sample comprised 527 mBCCs patients (36.1% females; 6.8% GGS; 5.5% OKCs; mean age, 74.5 ± 15.8 years [range, 15-102]). There was a significant association between syndromic mBCCs and jaw cysts ( P < .0001; NNS = 2 [95% CI, CI, 1.1 to 1.4]). In the adjusted logistic model, PaR identified GGS via radiographic diagnosis of jaw cysts in case of 1) age ≤ 35 years,...