Francis McCormack | University of Cincinnati College of Medicine (original) (raw)

Uploads

Papers by Francis McCormack

Research paper thumbnail of Peptides with antioxidant and antimicrobial properties

Research paper thumbnail of Kinetic Moment Equations for a Gas of Polyatomic Molecules with Many Internal Degrees of Freedom

Physics of Fluids, 1970

ABSTRACT

Research paper thumbnail of IONIZATION, ELECTRON ATTACHMENT, AND INELASTIC COLLISIONS IN THE MICROSCOPIC THEORY OF MOLECULAR AND IONIZED GASES (Thesis)

Research paper thumbnail of Kinetic Equations for Polyatomic Gases: The 17-Moment Approximation

Physics of Fluids, 1968

ABSTRACT

Research paper thumbnail of Inelastic Boltzmann Equation for Slightly Ionized Gases

Physical Review, 1969

... (28) constitute the purely elastic contribution, and are in agreement with the results obtain... more ... (28) constitute the purely elastic contribution, and are in agreement with the results obtained by Chapman and Cowling' and Desloge and Matthysse.6V ... E. . (29) If this be the case, we can reasonably approximate vii andfo*(vij) in (27) by the first few terms of their Taylor series. ...

Research paper thumbnail of Construction of linearized kinetic models for gaseous mixtures and molecular gases

Research paper thumbnail of Anisotropic Relaxation in Binary Mixture of Maxwell Molecules

Physics of Fluids, 1972

The relaxation of initial temperature difference, stresses and heat fluxes in a binary mixture of... more The relaxation of initial temperature difference, stresses and heat fluxes in a binary mixture of Maxwell molecules is studied by solving the two-temperature 13-moment equations for the mixture under the assumption of spatial homogeneity. For simplicity, the flow velocities for each gas are assumed to be the same, and the rates at which the stresses and heat fluxes relax are

Research paper thumbnail of Greenspan Rule for Combined Absorption of Sound in Polyatomic Gases with Many Internal Degrees of Freedom

The Journal of the Acoustical Society of America, 1972

Research paper thumbnail of 17-Moment Theory of Sound Propagation in Polyatomic Gases

The Journal of the Acoustical Society of America, 1972

Research paper thumbnail of Kinetic theory of sound propagation in gaseous mixtures. I. Two-fluid 5-moment, 13-moment, and Navier-Stokes Theories

The Journal of the Acoustical Society of America, 1974

Research paper thumbnail of Rate of Exchange of Energy through Inelastic Collisions between Two Gases at Different Temperatures

The Journal of Chemical Physics, 1968

Research paper thumbnail of FORMAC routine for computing the matrix elements of the linearized cross-collision operators of gaseous mixtures

Computer Physics Communications, 1975

ABSTRACT

Research paper thumbnail of Comments on: “Derivation of the Davydov Distribution from the Boltzmann Equation”

American Journal of Physics, 1971

Research paper thumbnail of The Poorman's Macroscopic Scattering Analyzer

American Journal of Physics, 1969

A scattering apparatus has been developed which is quite useful for teaching concepts in atomic a... more A scattering apparatus has been developed which is quite useful for teaching concepts in atomic and nuclear physics. The apparatus permits the students the opportunity for actually measuring differential cross sections, back angle scattering cross sections, capture cross sections, threshold energies and resonant energies. The classical mechanics problem involved in this scattering apparatus is discussed.

Research paper thumbnail of Smooth transitions between the three damping cases for the harmonic oscillator

American Journal of Physics, 1995

Research paper thumbnail of Pulmonary Alveolar Microlithiasis

American Journal of Respiratory and Critical Care Medicine, Jan 10, 2013

A 59-year-old Middle Eastern female with a history of pulmonary alveolar microlithiasis (PAM) was... more A 59-year-old Middle Eastern female with a history of pulmonary alveolar microlithiasis (PAM) was referred to our clinic for second opinion. The patient had been diagnosed in her childhood but was asymptomatic until she developed exertional dyspnea at the age of 54 years. Chest examination revealed bibasilar crackles. Pulmonary function tests revealed mild restriction and reduced diffusing capacity. Six-minute-walk test revealed normal exercise capacity (distance walked, 1,800 ft) with mild exertional desaturation to 88%. Chest X-ray ( ) showed remarkable, fine nodular lower lung zone opacities, and computed tomography of the chest showed symmetrical lower lobe predominant micronodular calcifications along bronchovascular bundles and interlobular septal thickening, findings pathognomonic for PAM (1). PAM is caused by inactivating mutations in the SCL34A2 gene (2, 3). The mutation leads to reduced phosphate reuptake by type IIb sodium phosphate transporter in the apical membrane of type II alveolar cells, resulting in calcium phosphate chelation and microlith formation in alveolar air spaces. PAM is associated with consanguinity, and the incidence is higher in Turkey, Japan, India, and Italy. PAM can be diagnosed on the basis of characteristic radiological findings (4), and biopsy is not usually required. The clinical course of PAM is highly variable, with some patients developing pulmonary fibrosis and others remaining asymptomatic for decades. Etidronate, a bisphosphonate, reduces the formation of calcium hydroxyapatite crystals and has led to clinical and radiological improvement in few cases of PAM (5). The patient was started on treatment with etidronate.

Research paper thumbnail of Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations

Biochemistry, Jan 5, 2016

Surfactant protein A (SP-A) is a collagenous C-type lectin (collectin) that is critical for pulmo... more Surfactant protein A (SP-A) is a collagenous C-type lectin (collectin) that is critical for pulmonary defense against inhaled microorganisms. Bifunctional avidity of SP-A for pathogen-associated molecular patterns (PAMPs) such as lipid A and for dipalmitoylphosphatidylcholine (DPPC), the major component of surfactant membranes lining the air-liquid interface of the lung, ensures that the protein is poised for first-line interactions with inhaled pathogens. To improve our understanding of the motifs that are required for interactions with microbes and surfactant structures, we explored the role of the tyrosine-rich binding surface on the carbohydrate recognition domain of SP-A in the interaction with DPPC and lipid A using crystallography, site-directed mutagenesis, and molecular dynamics simulations. Critical binding features for DPPC binding include a three-walled tyrosine cage that binds the choline headgroup through cation-π interactions and a positively charged cluster that bind...

Research paper thumbnail of Lymphangioleiomyomatosis: Insights about, and from, a Rare Disease

Amer J Respir Crit Care Med, 2003

... Insights about, and from, a Rare Disease. Kathy E. Sietsema, MD a and Francis X. McCormack, M... more ... Insights about, and from, a Rare Disease. Kathy E. Sietsema, MD a and Francis X. McCormack, MD b ... Taveira-DaSilva AM, Stylianou MP, Hedin CJ, Kristof AS, Avila NA, Rabel A, Travis WD, Moss J. Maximal oxygen uptake and severity of disease in lymphangioleiomyomatosis. ...

Research paper thumbnail of Reply: Characterization of Lymphangioleiomyomatosis as a Neoplastic Disease

American Journal of Respiratory and Critical Care Medicine, Aug 1, 2013

Research paper thumbnail of Susceptibility of Hermansky-Pudlak Mice to Bleomycin-Induced Type II Cell Apoptosis and Fibrosis

American Journal of Respiratory Cell and Molecular Biology, Dec 20, 2012

Pulmonary inflammation, abnormalities in type II cell and macrophage morphology, and pulmonary fi... more Pulmonary inflammation, abnormalities in type II cell and macrophage morphology, and pulmonary fibrosis are features of Hermansky-Pudlak Syndrome (HPS), a recessive disorder associated with intracellular trafficking defects. We have previously reported that "Pearl" (HPS2) and "Pale Ear" (HPS1) mouse models have pulmonary inflammatory dysregulation and constitutive alveolar macrophage (AM) activation (Young LR et al., J Immunol 2006;176:4361-4368). In the current study, we used these HPS models to investigate mechanisms of lung fibrosis. Unchallenged HPS1 and HPS2 mice have subtle airspace enlargement and foamy AMs, but little or no histologic evidence of lung fibrosis. Seven days after intratracheal bleomycin (0.025 units), HPS1 and HPS2 mice exhibited increased mortality and diffuse pulmonary fibrosis compared to strain-matched C57BL/6J wildtype (WT) mice. HPS mice had significantly increased collagen deposition, and reduced quasi-static and static compliance consistent with a restrictive defect. The early airway and parenchymal cellular inflammatory responses to bleomycin were similar in HPS2 and WT mice. Greater elevations in levels of TGF-␤ and IL-12p40 were produced in the lungs and AMs from bleomycin-challenged HPS mice than in WT mice. TUNEL staining revealed apoptosis of type II cells as early as 5 h after low-dose bleomycin challenge in HPS mice, suggesting that type II cell susceptibility to apoptosis may play a role in the fibrotic response. We conclude that the trafficking abnormalities in HPS promote alveolar apoptosis and pulmonary fibrosis in response to bleomycin challenge.

Research paper thumbnail of Peptides with antioxidant and antimicrobial properties

Research paper thumbnail of Kinetic Moment Equations for a Gas of Polyatomic Molecules with Many Internal Degrees of Freedom

Physics of Fluids, 1970

ABSTRACT

Research paper thumbnail of IONIZATION, ELECTRON ATTACHMENT, AND INELASTIC COLLISIONS IN THE MICROSCOPIC THEORY OF MOLECULAR AND IONIZED GASES (Thesis)

Research paper thumbnail of Kinetic Equations for Polyatomic Gases: The 17-Moment Approximation

Physics of Fluids, 1968

ABSTRACT

Research paper thumbnail of Inelastic Boltzmann Equation for Slightly Ionized Gases

Physical Review, 1969

... (28) constitute the purely elastic contribution, and are in agreement with the results obtain... more ... (28) constitute the purely elastic contribution, and are in agreement with the results obtained by Chapman and Cowling' and Desloge and Matthysse.6V ... E. . (29) If this be the case, we can reasonably approximate vii andfo*(vij) in (27) by the first few terms of their Taylor series. ...

Research paper thumbnail of Construction of linearized kinetic models for gaseous mixtures and molecular gases

Research paper thumbnail of Anisotropic Relaxation in Binary Mixture of Maxwell Molecules

Physics of Fluids, 1972

The relaxation of initial temperature difference, stresses and heat fluxes in a binary mixture of... more The relaxation of initial temperature difference, stresses and heat fluxes in a binary mixture of Maxwell molecules is studied by solving the two-temperature 13-moment equations for the mixture under the assumption of spatial homogeneity. For simplicity, the flow velocities for each gas are assumed to be the same, and the rates at which the stresses and heat fluxes relax are

Research paper thumbnail of Greenspan Rule for Combined Absorption of Sound in Polyatomic Gases with Many Internal Degrees of Freedom

The Journal of the Acoustical Society of America, 1972

Research paper thumbnail of 17-Moment Theory of Sound Propagation in Polyatomic Gases

The Journal of the Acoustical Society of America, 1972

Research paper thumbnail of Kinetic theory of sound propagation in gaseous mixtures. I. Two-fluid 5-moment, 13-moment, and Navier-Stokes Theories

The Journal of the Acoustical Society of America, 1974

Research paper thumbnail of Rate of Exchange of Energy through Inelastic Collisions between Two Gases at Different Temperatures

The Journal of Chemical Physics, 1968

Research paper thumbnail of FORMAC routine for computing the matrix elements of the linearized cross-collision operators of gaseous mixtures

Computer Physics Communications, 1975

ABSTRACT

Research paper thumbnail of Comments on: “Derivation of the Davydov Distribution from the Boltzmann Equation”

American Journal of Physics, 1971

Research paper thumbnail of The Poorman's Macroscopic Scattering Analyzer

American Journal of Physics, 1969

A scattering apparatus has been developed which is quite useful for teaching concepts in atomic a... more A scattering apparatus has been developed which is quite useful for teaching concepts in atomic and nuclear physics. The apparatus permits the students the opportunity for actually measuring differential cross sections, back angle scattering cross sections, capture cross sections, threshold energies and resonant energies. The classical mechanics problem involved in this scattering apparatus is discussed.

Research paper thumbnail of Smooth transitions between the three damping cases for the harmonic oscillator

American Journal of Physics, 1995

Research paper thumbnail of Pulmonary Alveolar Microlithiasis

American Journal of Respiratory and Critical Care Medicine, Jan 10, 2013

A 59-year-old Middle Eastern female with a history of pulmonary alveolar microlithiasis (PAM) was... more A 59-year-old Middle Eastern female with a history of pulmonary alveolar microlithiasis (PAM) was referred to our clinic for second opinion. The patient had been diagnosed in her childhood but was asymptomatic until she developed exertional dyspnea at the age of 54 years. Chest examination revealed bibasilar crackles. Pulmonary function tests revealed mild restriction and reduced diffusing capacity. Six-minute-walk test revealed normal exercise capacity (distance walked, 1,800 ft) with mild exertional desaturation to 88%. Chest X-ray ( ) showed remarkable, fine nodular lower lung zone opacities, and computed tomography of the chest showed symmetrical lower lobe predominant micronodular calcifications along bronchovascular bundles and interlobular septal thickening, findings pathognomonic for PAM (1). PAM is caused by inactivating mutations in the SCL34A2 gene (2, 3). The mutation leads to reduced phosphate reuptake by type IIb sodium phosphate transporter in the apical membrane of type II alveolar cells, resulting in calcium phosphate chelation and microlith formation in alveolar air spaces. PAM is associated with consanguinity, and the incidence is higher in Turkey, Japan, India, and Italy. PAM can be diagnosed on the basis of characteristic radiological findings (4), and biopsy is not usually required. The clinical course of PAM is highly variable, with some patients developing pulmonary fibrosis and others remaining asymptomatic for decades. Etidronate, a bisphosphonate, reduces the formation of calcium hydroxyapatite crystals and has led to clinical and radiological improvement in few cases of PAM (5). The patient was started on treatment with etidronate.

Research paper thumbnail of Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations

Biochemistry, Jan 5, 2016

Surfactant protein A (SP-A) is a collagenous C-type lectin (collectin) that is critical for pulmo... more Surfactant protein A (SP-A) is a collagenous C-type lectin (collectin) that is critical for pulmonary defense against inhaled microorganisms. Bifunctional avidity of SP-A for pathogen-associated molecular patterns (PAMPs) such as lipid A and for dipalmitoylphosphatidylcholine (DPPC), the major component of surfactant membranes lining the air-liquid interface of the lung, ensures that the protein is poised for first-line interactions with inhaled pathogens. To improve our understanding of the motifs that are required for interactions with microbes and surfactant structures, we explored the role of the tyrosine-rich binding surface on the carbohydrate recognition domain of SP-A in the interaction with DPPC and lipid A using crystallography, site-directed mutagenesis, and molecular dynamics simulations. Critical binding features for DPPC binding include a three-walled tyrosine cage that binds the choline headgroup through cation-π interactions and a positively charged cluster that bind...

Research paper thumbnail of Lymphangioleiomyomatosis: Insights about, and from, a Rare Disease

Amer J Respir Crit Care Med, 2003

... Insights about, and from, a Rare Disease. Kathy E. Sietsema, MD a and Francis X. McCormack, M... more ... Insights about, and from, a Rare Disease. Kathy E. Sietsema, MD a and Francis X. McCormack, MD b ... Taveira-DaSilva AM, Stylianou MP, Hedin CJ, Kristof AS, Avila NA, Rabel A, Travis WD, Moss J. Maximal oxygen uptake and severity of disease in lymphangioleiomyomatosis. ...

Research paper thumbnail of Reply: Characterization of Lymphangioleiomyomatosis as a Neoplastic Disease

American Journal of Respiratory and Critical Care Medicine, Aug 1, 2013

Research paper thumbnail of Susceptibility of Hermansky-Pudlak Mice to Bleomycin-Induced Type II Cell Apoptosis and Fibrosis

American Journal of Respiratory Cell and Molecular Biology, Dec 20, 2012

Pulmonary inflammation, abnormalities in type II cell and macrophage morphology, and pulmonary fi... more Pulmonary inflammation, abnormalities in type II cell and macrophage morphology, and pulmonary fibrosis are features of Hermansky-Pudlak Syndrome (HPS), a recessive disorder associated with intracellular trafficking defects. We have previously reported that "Pearl" (HPS2) and "Pale Ear" (HPS1) mouse models have pulmonary inflammatory dysregulation and constitutive alveolar macrophage (AM) activation (Young LR et al., J Immunol 2006;176:4361-4368). In the current study, we used these HPS models to investigate mechanisms of lung fibrosis. Unchallenged HPS1 and HPS2 mice have subtle airspace enlargement and foamy AMs, but little or no histologic evidence of lung fibrosis. Seven days after intratracheal bleomycin (0.025 units), HPS1 and HPS2 mice exhibited increased mortality and diffuse pulmonary fibrosis compared to strain-matched C57BL/6J wildtype (WT) mice. HPS mice had significantly increased collagen deposition, and reduced quasi-static and static compliance consistent with a restrictive defect. The early airway and parenchymal cellular inflammatory responses to bleomycin were similar in HPS2 and WT mice. Greater elevations in levels of TGF-␤ and IL-12p40 were produced in the lungs and AMs from bleomycin-challenged HPS mice than in WT mice. TUNEL staining revealed apoptosis of type II cells as early as 5 h after low-dose bleomycin challenge in HPS mice, suggesting that type II cell susceptibility to apoptosis may play a role in the fibrotic response. We conclude that the trafficking abnormalities in HPS promote alveolar apoptosis and pulmonary fibrosis in response to bleomycin challenge.