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TY - CHAP AU - Hourani, Mou'ath AU - Berretta, Regina AU - Mendes, Alexandre AU - Moscato, Pablo ED - Keith, Jonathan M. PY - 2008 DA - 2008// TI - Genetic Signatures for a Rodent Model of Parkinson's Disease Using Combinatorial Optimization Methods BT - Bioinformatics: Structure, Function and Applications SP - 379 EP - 392 PB - Humana Press CY - Totowa, NJ AB - This chapter illustrates the use of the combinatorial optimization models presented in Chapter 19for the Feature Set selection and Gene Ordering problems to find genetic signatures for diseases using micro-array data. We demonstrate the quality of this approach by using a microarray dataset from a mouse model of Parkinson's disease. The results are accompanied by a description of the currently known molecular functions and biological processes of the genes in the signatures. SN - 978-1-60327-429-6 UR - https://doi.org/10.1007/978-1-60327-429-6\_20 DO - 10.1007/978-1-60327-429-6_20 ID - Hourani2008 ER -