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TY - CHAP AU - Spruck, Charles H. AU - Rideout, William M. AU - Jones, Peter A. ED - Jost, Jean-Pierre ED - Saluz, Hans-Peter PY - 1993 DA - 1993// TI - DNA Methylation and cancer BT - DNA Methylation: Molecular Biology and Biological Significance SP - 487 EP - 509 PB - Birkhäuser Basel CY - Basel AB - The methylation of cytosine at the 5′ position in the CpG dinucleotide palindrome is the only known epigenetic modification in vertebrate DNA. Although 5-methylcytosine (5-mC) comprises only 1–3% of the bases in the genome, it may play an important role in carcinogenesis through its ability to influence gene expression and increase mutational frequencies in genes involved in carcinogenesis. SN - 978-3-0348-9118-9 UR - https://doi.org/10.1007/978-3-0348-9118-9\_22 DO - 10.1007/978-3-0348-9118-9_22 ID - Spruck1993 ER -