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TY - JOUR AU - Defais, Martine AU - Caillet-Fauquet, Perrine AU - Fox, Maurice S. AU - Radman, Miroslav PY - 1976 DA - 1976/01/01 TI - Induction kinetics of mutagenic DNA repair activity in E. coli following ultraviolet irradiation JO - Molecular and General Genetics MGG SP - 125 EP - 130 VL - 148 IS - 2 AB - Ultraviolet mutagenesis of phage λ is produced by host functions which are inducible by ultraviolet irradiation of the host cell. Induction kinetics and the half life of the inducible mutagenic DNA repair (SOS-repair) in E. coli have been determined using phage λ assays. At 37°C, both mutagenic and repair activities are maximal approximately 30 min following irradiation and decay with a half life of approximately 30 min. The presence of 100 μg/ml chloramphenicol during the first 40 min after irradiation completely abolishes induction of repair and mutagenesis. The ultraviolet induction pattern of SOS repair very much resembles that of λ prophage in lysogenic induction (Monk and Kinross, 1975). SN - 1432-1874 UR - https://doi.org/10.1007/BF00268375 DO - 10.1007/BF00268375 ID - Defais1976 ER -