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TY - JOUR AU - Arber, Werner AU - Wauters-Willems, Danièle PY - 1970 DA - 1970/09/01 TI - Host specificity of DNA produced by Escherichia coli JO - Molecular and General Genetics MGG SP - 203 EP - 217 VL - 108 IS - 3 AB - E. coli 15T- carries two distinct sets of DNA restriction and modification activities. The genetic information for system A is contained in the bacterial chromosome and linked to the thr region. This fact suggests host specificity A to be related to those of strains K and B. The genes controlling system 15 are on a plasmid which is related to phage Pl: it competes with Pl for stable inheritance in the carried state and it genetically recombines with Pl. This recombination may produce plasmid genomes with newly assorted characters (see Table 3). One of them is an active, Pl-like prophage with the 15-specific instead of the parental Pl-specific restriction and modification characters. Superinfection of 15T- with Pl may also result in curing of the bacteria from the restriction plasmid. SN - 1432-1874 UR - https://doi.org/10.1007/BF00283350 DO - 10.1007/BF00283350 ID - Arber1970 ER -