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TY - JOUR AU - Georgopoulos, C. P. PY - 1977 DA - 1977/01/01 TI - A new bacterial gene (groPC) which affects λ DNA replication JO - Molecular and General Genetics MGG SP - 35 EP - 39 VL - 151 IS - 1 AB - A bacterial mutation affecting λ DNA replication, called groPC756, has been mapped between the thr and leu bacterial loci. Most of the parental λ DNA does not undergo even one round of replication in this host. Lambda mutants, called π, which map in the λ P gene are able to overcome the inhibitory effect of the groPC756 mutation. It is shown that the mutation at the groPC locus also interferes with bacterial growth at 42°C. A λ-transducing phage, carrying the groPC+ allele, was isolated as a plaqueformer on groPC756 bacteria. Upon lysogenization, it restores both the gro+ and temperature resistant phenotypes. SN - 1432-1874 UR - https://doi.org/10.1007/BF00446910 DO - 10.1007/BF00446910 ID - Georgopoulos1977 ER -