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TY - JOUR AU - Jukes, Thomas H. AU - Bhushan, Vikas PY - 1986 DA - 1986/12/01 TI - Silent nucleotide substitutions and G+C content of some mitochondrial and bacterial genes JO - Journal of Molecular Evolution SP - 39 EP - 44 VL - 24 IS - 1 AB - The G+C content of DNA varies widely in different organisms, especially microorganisms. This variation is accompanied by changes in the nucleotide composition of silent positions in codons. (Silent positions are defined and explained in the text.) These changes are mostly neutral or near neutral, and appear to result from mutation pressure in the direction of increasing either A+T (AT pressure) or G+C(GC pressure) content. Variations in G+C content are also accompanied by substitutions at replacement positions in codons. These substituions produce changes in the amino acid content of homologous proteins. The examples studied were genes for 13 mitochondrial proteins in five species, and A and B genes for bacterial tryptophan synthase in four species. SN - 1432-1432 UR - https://doi.org/10.1007/BF02099949 DO - 10.1007/BF02099949 ID - Jukes1986 ER -