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TY - JOUR AU - Nakashima, M. AU - Eguchi, K. AU - Ishikawa, N. AU - Yamashita, I. AU - Sakai, M. AU - Ida, H. AU - Kawabe, Y. AU - Ito, K. AU - Nagataki, S. PY - 1994 DA - 1994/12/01 TI - Expression of adhesion molecule ICAM-1 (CD54) in thyroid papillary adenocarcinoma JO - Journal of Endocrinological Investigation SP - 843 EP - 848 VL - 17 IS - 11 AB - The expression of adhesion molecules in thyroid specimens from 10 cases of papillary adenocarcinoma, 5 cases of follicular adenoma and 3 normal thyroid specimens was examined by an immunohistochemical method. Thyroid epithelial cells from all cases of papillary adenocarcinoma expressed the intercellular adhesion molecule 1 (ICAM-1, CD54). The ICAM-1-positive staining in these was detected predominantly on the apical site of malignant thyroid epithelial cells. However, no ICAM-1 expression was detected on thyrocytes of adenoma, and normal thyroid tissues. Furthermore, thyroid epithelial cells in patients with thyroid tumor and normal thyroid tissue did not react with anti-LFA-1, anti-VLA-4, anti-VCAM-1 and anti-ELAM-1 monoclonal antibodies. It is speculated that ICAM-1 expression in thyroid papillary adenocarcinoma may have a functional significance. SN - 1720-8386 UR - https://doi.org/10.1007/BF03347789 DO - 10.1007/BF03347789 ID - Nakashima1994 ER -