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TY - JOUR AU - Blackburn, Neil T. AU - Clarke, Anthony J. PY - 2001 DA - 2001/01/01 TI - Identification of Four Families of Peptidoglycan Lytic Transglycosylases JO - Journal of Molecular Evolution SP - 78 EP - 84 VL - 52 IS - 1 AB - The lytic transglycosylases are a class of autolysins which cleave the bacterial cell wall heteropolymer peptidoglycan (murein) to facilitate its biosynthesis and turnover. A search of the National Center for Biotechnology Information (NCBI) databases using the primary sequences of the six characterized lytic transglycosylases of Escherichia coli, a membrane-bound form of the enzyme from Pseudomonas aeruginosa, and the endolysins of λ bacteriophage permitted the identification of a total of 127 known and hypothetical enzymes from a wide variety of bacteria and bacteriophage. These amino acid sequences have been arranged into four families based on alignments, and consensus motifs have been identified. Family 1 represents a superfamily comprising 86 sequences which are subdivided into five (1A–1E) subfamilies. SN - 1432-1432 UR - https://doi.org/10.1007/s002390010136 DO - 10.1007/s002390010136 ID - Blackburn2001 ER -