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TY - JOUR AU - Ugurel, Selma AU - Schrama, David AU - Keller, Gunhild AU - Schadendorf, Dirk AU - Bröcker, Eva-Bettina AU - Houben, Roland AU - Zapatka, Marc AU - Fink, Wolfram AU - Kaufman, Howard L. AU - Becker, Jürgen C. PY - 2008 DA - 2008/05/01 TI - Impact of the CCR5 gene polymorphism on the survival of metastatic melanoma patients receiving immunotherapy JO - Cancer Immunology, Immunotherapy SP - 685 EP - 691 VL - 57 IS - 5 AB - Chemokines influence both tumor progression and anti-tumor immune response. A 32-bp-deletion polymorphism in the chemokine receptor 5 gene (CCR5Δ32) has been shown to result in a non-functional protein. This study was aimed at evaluating the potential impact of this gene polymorphism on disease progression and treatment outcome in patients with melanoma. SN - 1432-0851 UR - https://doi.org/10.1007/s00262-007-0407-z DO - 10.1007/s00262-007-0407-z ID - Ugurel2008 ER -