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TY - JOUR AU - Wandall, Annelise AU - Tranebjærg, Lisbeth AU - Tommerup, Niels PY - 1998 DA - 1998/12/01 TI - A neocentromere on human chromosome 3 without detectable α-satellite DNA forms morphologically normal kinetochores JO - Chromosoma SP - 359 EP - 365 VL - 107 IS - 6 AB - A neocentromere at 3q26 was observed in a father and his daughter on a chromosome 3 with deleted centromeric region. No α-satellite DNA was detectable at the 3q26 neocentromere, but it was weakly positive with anticentromere (CREST) antibodies. Electron microscopy showed that the neocentromere formed microtubule-associated kinetochores with normal morphology and of the same size as the kinetochores of other large chromosomes. The deleted centromere formed a small linear marker chromosome that reacted strongly with anticentromere antibodies, but showed reduced kinetochore size. The 3q26 neokinetochore was stable under adverse growth conditions, which often caused kinetochore loss in the original 3-centromere on the small marker. SN - 1432-0886 UR - https://doi.org/10.1007/s004120050319 DO - 10.1007/s004120050319 ID - Wandall1998 ER -