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TY - JOUR AU - Telford, M. J. AU - Thomas, Richard H. PY - 1998 DA - 1998/11/01 TI - Of mites and zen: expression studies in a chelicerate arthropod confirm zen is a divergent Hox gene JO - Development Genes and Evolution SP - 591 EP - 594 VL - 208 IS - 10 AB - We have cloned, from an oribatid mite, a gene homologous to the zerknült (zen) genes of insects and the Hox 3 genes of vertebrates. Hox genes specify cell fates in specific regions of the body in all metazoans studied and are expressed in antero-posteriorly restricted regions of the embryo. This is true of the vertebrate Hox 3 but not of the zen genes, the insect homologs, and it has been proposed that the zen genes have lost their Hox-like function in the ancestor of the insects. We studied expression of a mite Hox 3/zen homolog and found that it is expressed in a discrete antero-posterior region of the body with an anterior boundary coinciding with that of the chelicerate homolog of the Drosophila Hox gene, proboscipedia, and propose that its loss of Hox function in insects is due to functional redundancy due to this overlap with another Hox gene. SN - 1432-041X UR - https://doi.org/10.1007/s004270050219 DO - 10.1007/s004270050219 ID - Telford1998 ER -