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TY - JOUR AU - Boivin, A. AU - Fauvarque, M.-O. AU - Dura, J.-M. PY - 1999 DA - 1999/02/01 TI - One-to-one correspondence between the two genetic units and the tandemly duplicated transcriptional units of the polyhomeotic locus of Drosophila JO - Molecular and General Genetics MGG SP - 196 EP - 200 VL - 261 IS - 1 AB - polyhomeotic (ph) is a complex locus in Drosophila defined by two genetic units. Two mutational events are necessary to obtain the null lethal phenotype. Molecular analysis has shown that the ph locus contains two transcriptional units coding for two very similar proteins. Although a strong argument in favor of a strict correlation between the genetic and molecular units can be constructed, there is no direct evidence for the hypothesis. Here, we show for all cases with detectable molecular defects that X-ray-induced generation of an amorphic allele from a pre-existing X-ray-induced hypomorphic allele with a lesion limited to one unit invariably involves a rearrangement in the other unit. This result proves that each genetic unit corresponds to one transcription unit. SN - 1432-1874 UR - https://doi.org/10.1007/s004380050957 DO - 10.1007/s004380050957 ID - Boivin1999 ER -