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TY - JOUR AU - GUO, HONGHUI AU - LING, WENHUA AU - WANG, QING AU - LIU, CHI AU - HU, YAN AU - XIA, MIN AU - FENG, XIANG AU - XIA, XIAODONG PY - 2007 DA - 2007/03/01 TI - Effect of Anthocyanin-Rich Extract from Black Rice (Oryza sativa L. indica) on Hyperlipidemia and Insulin Resistance in Fructose-Fed Rats JO - Plant Foods for Human Nutrition SP - 1 EP - 6 VL - 62 IS - 1 AB - This study was designed to evaluate the effect of an anthocyanin-rich extract from black rice on hyperlipidemia and insulin resistance in fructose-fed rats. Rats fed fructose diet for 4 weeks exhibited significantly higher plasma insulin levels and lower insulin sensitivity than the control rats fed AIN-93G diet. Dietary supplementation with the anthocyanin-rich extract (5 g/kg of high-fructose diet) prevented the development of fructose-induced insulin resistance. After fructose-induced insulin resistance had been established, 4-week treatment with the anthocyanin-rich extract (5 g/kg of high-fructose diet) or pioglitazone (270 mg/kg of high-fructose diet) ameliorated the glucose intolerance and hyperlipidemia, but the extract failed to reverse the fructose-induced hyperinsulinemia as pioglitazone did. In addition, rats supplemented by the extract exhibited lower oxidative stress than the fructose-fed controls, as indicated by the lower concentrations of plasma thiobarbituric acid reactive substances and blood oxidized glutathione. Overall, these results suggest that the anthocyanin-rich extract from black rice improves certain metabolic abnormalities associated with diets high in fructose. SN - 1573-9104 UR - https://doi.org/10.1007/s11130-006-0031-7 DO - 10.1007/s11130-006-0031-7 ID - GUO2007 ER -