(original) (raw)

TY - JOUR AU - Nagatomo, Akifumi AU - Inoue, Naoki AU - Konno, Takuya AU - Xu, Yin AU - Sakamoto, Chinatsu AU - Sone, Mayuko AU - Shibasaka, Aya AU - Muraoka, Osamu AU - Ninomiya, Kiyofumi AU - Yoshikawa, Masayuki AU - Manse, Yoshiaki AU - Morikawa, Toshio PY - 2022 DA - 2022/06/01 TI - Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil. JO - Journal of Natural Medicines SP - 654 EP - 669 VL - 76 IS - 3 AB - The methanol extract from the leaves of Ilex paraguariensis A. St.-Hil. (Aquifoliaceae), popularly known as mate, maté, or yerba maté, inhibits the intracellular triglyceride accumulation in HepG2 cells and suppresses the plasma triglyceride elevation in olive oil-treated mice. Three new triterpene saponins, termed mateosides I (1), II (2), and III (3), were isolated from the extract along with 29 known compounds. The structures of 1–3 were elucidated based on chemical and spectroscopic evidence. Among the isolates, principal saponin constituents, 2 and matesaponins 1 (7) and 2 (9), potently inhibited the triglyceride accumulation in HepG2 cells simultaneously treated with oleic acid and high glucose. In vivo assay of the methanol extract of I. paraguariensis revealed that 7 and 9 showed anti-hyperlipidemic activities in olive oil-treated mice. These results suggested that the saponin constituents of I. paraguariensis could be valuable bioactive marker for the anti-obesogenic activity. SN - 1861-0293 UR - https://doi.org/10.1007/s11418-022-01614-5 DO - 10.1007/s11418-022-01614-5 ID - Nagatomo2022 ER -