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TY - JOUR AU - Su, Tung-Ping AU - Schmidt, Peter J AU - Danaceau, Merry A AU - Tobin, Marie B AU - Rosenstein, Donald L AU - Murphy, Dennis L AU - Rubinow, David R PY - 1997 DA - 1997/05/01 TI - Fluoxetine in the Treatment of Premenstrual Dysphoria JO - Neuropsychopharmacology SP - 346 EP - 356 VL - 16 IS - 5 AB - We performed a double-blind, placebo-controlled, crossover trial of fluoxetine in 17 women with prospectively confirmed PMS who also met criteria for premenstrual dysphoric disorder (PMDD). A subset of 10 women with PMDD and an additional 10 controls participated in a single-dose m-chlorophenylpiperazine (m-CPP) challenge during the follicular and luteal phases of the menstrual cycle. We evaluated the ability of the acute behavioral response to luteal phase m-CPP administration to predict therapeutic response to fluoxetine. Compared with baseline, fluoxetine, but not placebo, treatment significantly improved both emotional and physical symptoms. We identified 11 (65%) fluoxetine responders who no longer met diagnostic criteria for PMDD during fluoxetine but remained symptomatic during placebo treatment. In addition, acute symptomatic improvement also occurred following m-CPP administration in 7 of 10 women with PMDD. The small number of m-CPP nonresponders did not respond to fluoxetine either. Our findings confirm that fluoxetine is an effective treatment of PMDD. SN - 1740-634X UR - https://doi.org/10.1016/S0893-133X(96)00245-X DO - 10.1016/S0893-133X(96)00245-X ID - Su1997 ER -