(original) (raw)

TY - JOUR AU - Magnusson, Patrik K. E. AU - Sparén, Pär AU - Gyllensten, Ulf B. PY - 1999 DA - 1999/07/01 TI - Genetic link to cervical tumours JO - Nature SP - 29 EP - 30 VL - 400 IS - 6739 AB - Cervical cancer is strongly associated with infection by oncogenic types of human papilloma virus (HPV). But only a small fraction of those infected develop cancer, indicating that other factors contribute to the progression to cervical cancer. We have compared incidence of the disease in relatives of cases of cervical tumour and controls, and find a significant familial clustering among biological, but not adoptive, relatives. We find no difference in the risk to siblings who have a mother or father in common, so the clustering cannot be explained by vertical transmission of HPV from mother to child. These results provide epidemiological evidence of a genetic predisposition to cervical cancer. SN - 1476-4687 UR - https://doi.org/10.1038/21801 DO - 10.1038/21801 ID - Magnusson1999 ER -