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TY - JOUR AU - LIN, SYR-YAUNG AU - RIGGS, ARTHUR D. PY - 1970 DA - 1970/12/01 TI - Lac Repressor Binding to DNA not containing the Lac Operator and to Synthetic Poly dAT JO - Nature SP - 1184 EP - 1186 VL - 228 IS - 5277 AB - THE lac represser binds very specifically and tightly to the lac operator1–3. In conditions where the repressor binds to operator with a dissociation constant of 10−13 M, the binding of represser to DNA not containing the Escherichia coli lac operator (non-operator DNA) was less tight by several orders of magnitude3. Although weak, we thought this non-operator DNA binding could be highly significant and deserved careful study. We report here on the binding of lac represser to non-operator DNA from several natural sources and also to synthetic poly dAT. SN - 1476-4687 UR - https://doi.org/10.1038/2281184a0 DO - 10.1038/2281184a0 ID - LIN1970 ER -