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TY - JOUR AU - PFIZENMAIER, KLAUS AU - TROSTMANN, HOLGER AU - RÖLLINGHOFF, MARTIN AU - WAGNER, HERMANN PY - 1975 DA - 1975/11/01 TI - Temporary presence of self-reactive cytotoxic T lymphocytes during murine lymphocytic choriomeningitis JO - Nature SP - 238 EP - 240 VL - 258 IS - 5532 AB - MICE injected with lymphocytic choriomeningitis (LCM) virus generate specifically sensitised thymus-derived (T) lymphocytes1–3. Such cells have been shown1,2,4 in in vitro 51Cr-release assays to be cytotoxic to target cells infected with LCM virus. The specificity of the cytotoxic reaction has been inferred by the observation that the cytotoxic T lymphocytes (CTL) do not lyse noninfected target cells. Moreover, there is evidence that the activity of the CTLs generated is restricted to those virus infected target cells which are compatible with the CTLs in regard to the major histocompatibility complex (MHC)5. This peculiar restriction prompted us to study the specificity of CTLs generated in murine LCM. We observed that 4–6 d after infection with the LCM virus the CTLs generated are specifically cytotoxic to syngeneic target cells, irrespective of whether or not they are infected with LCM virus. On the other hand, as the infection proceeds in time, T-cell mediated cytotoxicity is increasingly restricted to virus-infected syngeneic cells. The results imply that during the early phase after infection, murine LCM may represent an autoimmune phenomenon. SN - 1476-4687 UR - https://doi.org/10.1038/258238a0 DO - 10.1038/258238a0 ID - PFIZENMAIER1975 ER -