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TY - JOUR AU - Alberts, Bruce AU - Sternglanz, Rolf PY - 1977 DA - 1977/10/01 TI - Recent excitement in the DNA replication problem JO - Nature SP - 655 EP - 661 VL - 269 IS - 5630 AB - It is now possible to reproduce most of the reactions involved in DNA replication using prokaryotic enzymes in vitro. Such systems have revealed that DNA replication is a complex process depending on a relatively large number of proteins, and that nucleoside triphosphate hydrolysis energy is used at several discrete steps. Much of the complexity of DNA replication may arise from the need for extreme copying fidelity. SN - 1476-4687 UR - https://doi.org/10.1038/269655a0 DO - 10.1038/269655a0 ID - Alberts1977 ER -