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TY - JOUR AU - Ishii, Naoaki AU - Fujii, Michihiko AU - Hartman, Philip S. AU - Tsuda, Michio AU - Yasuda, Kayo AU - Senoo-Matsuda, Nanami AU - Yanase, Sumino AU - Ayusawa, Dai AU - Suzuki, Kenshi PY - 1998 DA - 1998/08/01 TI - A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes JO - Nature SP - 694 EP - 697 VL - 394 IS - 6694 AB - Much attention has focused on the aetiology of oxidative damagein cellular and organismal ageing1,2,3,4. Especially toxic arethe reactive oxygen byproducts of respiration and other biological processes5. A mev-1 (kn1 ) mutant of Caenorhabditis elegans has been found to be hypersensitive to raised oxygen concentrations6,7. Unlike the wild type, its lifespan decreases dramatically as oxygen concentrations are increased from 1 to 60% (ref. 7). Strains bearing this mutation accumulate markers of ageing (such as fluorescent materials and protein carbonyls) faster than the wild type8,9. We show here that mev-1 encodes a subunit of the enzyme succinate dehydrogenase cytochrome b , which is a component of complex II of the mitochondrial electron transport chain. We found that the ability of complex II to catalyse electron transport from succinate to ubiquinone is compromised in mev-1 animals. This may cause an indirect increase in superoxide levels, which in turn leads to oxygen hypersensitivity and premature ageing. Our results indicate that mev-1 governs the rate of ageing by modulating the cellular response to oxidative stress. SN - 1476-4687 UR - https://doi.org/10.1038/29331 DO - 10.1038/29331 ID - Ishii1998 ER -