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TY - JOUR AU - Chang, Esther H. AU - Furth, Mark E. AU - Scolnick, Edward M. AU - Lowy, Douglas R. PY - 1982 DA - 1982/06/01 TI - Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus JO - Nature SP - 479 EP - 483 VL - 297 IS - 5866 AB - A normal human gene homologous to the p21 ras oncogene of Harvey murine sarcoma virus induced oncogenic transformation and high p21 ras levels in murine fibroblasts when this gene was ligated to a control element (the long terminal repeat) from a murine or feline retrovirus. These results indicate that high levels of a gene product encoded by a normal human oncogene can induce tumorigenic transformation. SN - 1476-4687 UR - https://doi.org/10.1038/297479a0 DO - 10.1038/297479a0 ID - Chang1982 ER -