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TY - JOUR AU - Lomedico, Peter T. AU - McAndrew, Stephen J. PY - 1982 DA - 1982/09/01 TI - Eukaryotic ribosomes can recognize preproinsulin initiation codons irrespective of their position relative to the 5′ end of mRNA JO - Nature SP - 221 EP - 226 VL - 299 IS - 5880 AB - The functional assay of a eukaryotic mRNA, into which additional AUG codons have been introduced by in vitro mutagenesis, shows that a translational initiation site need not necessarily be the nearest AUG codon to the 5′ end of a mRNA. Hence, the sequence surrounding the AUG, and not simply its position relative to the 5′ end of mRNA, appears to be important in determining initiation efficiency. SN - 1476-4687 UR - https://doi.org/10.1038/299221a0 DO - 10.1038/299221a0 ID - Lomedico1982 ER -