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TY - JOUR AU - Tabin, Clifford J. AU - Bradley, Scott M. AU - Bargmann, Cornelia I. AU - Weinberg, Robert A. AU - Papageorge, Alex G. AU - Scolnick, Edward M. AU - Dhar, Ravi AU - Lowy, Douglas R. AU - Chang, Esther H. PY - 1982 DA - 1982/11/01 TI - Mechanism of activation of a human oncogene JO - Nature SP - 143 EP - 149 VL - 300 IS - 5888 AB - The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein. SN - 1476-4687 UR - https://doi.org/10.1038/300143a0 DO - 10.1038/300143a0 ID - Tabin1982 ER -