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TY - JOUR AU - Schwab, Manfred AU - Alitalo, Kari AU - Varmus, Harold E. AU - Bishop, J. Michael AU - George, Donna PY - 1983 DA - 1983/06/01 TI - A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells JO - Nature SP - 497 EP - 501 VL - 303 IS - 5917 AB - The cellular oncogene c-Ki-ras is amplified 30- to 60-fold in cells of the mouse adrenocortical tumour Y1. The amplified oncogene is located in double minute chromosomes and in a homogeneously staining chromosomal region, common karyotypical anomalies of tumour cells. The amounts of c-Ki-ras specific mRNA and of the protein (p21) encoded by the amplified gene are correspondingly elevated. Amplification and enhanced expression of cellular oncogenes may contribute to the genesis and/or maintenance of at least some naturally occurring tumours. SN - 1476-4687 UR - https://doi.org/10.1038/303497a0 DO - 10.1038/303497a0 ID - Schwab1983 ER -