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TY - JOUR AU - Ullrich, A. AU - Coussens, L. AU - Hayflick, J. S. AU - Dull, T. J. AU - Gray, A. AU - Tam, A. W. AU - Lee, J. AU - Yarden, Y. AU - Libermann, T. A. AU - Schlessinger, J. AU - Downward, J. AU - Mayes, E. L. V. AU - Whittle, N. AU - Waterfield, M. D. AU - Seeburg, P. H. PY - 1984 DA - 1984/05/01 TI - Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells JO - Nature SP - 418 EP - 425 VL - 309 IS - 5967 AB - The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains. A single transmembrane region of 23 amino acids separates the extracellular EGF binding and cytoplasmic domains. The receptor gene is amplified and apparently rearranged in A431 cells, generating a truncated 2.8-kilobase mRNA which encodes only the extracellular EGF binding domain. SN - 1476-4687 UR - https://doi.org/10.1038/309418a0 DO - 10.1038/309418a0 ID - Ullrich1984 ER -