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TY - JOUR AU - Cole, S. T. AU - Brosch, R. AU - Parkhill, J. AU - Garnier, T. AU - Churcher, C. AU - Harris, D. AU - Gordon, S. V. AU - Eiglmeier, K. AU - Gas, S. AU - Barry, C. E. AU - Tekaia, F. AU - Badcock, K. AU - Basham, D. AU - Brown, D. AU - Chillingworth, T. AU - Connor, R. AU - Davies, R. AU - Devlin, K. AU - Feltwell, T. AU - Gentles, S. AU - Hamlin, N. AU - Holroyd, S. AU - Hornsby, T. AU - Jagels, K. AU - Krogh, A. AU - McLean, J. AU - Moule, S. AU - Murphy, L. AU - Oliver, K. AU - Osborne, J. AU - Quail, M. A. AU - Rajandream, M.-A. AU - Rogers, J. AU - Rutter, S. AU - Seeger, K. AU - Skelton, J. AU - Squares, R. AU - Squares, S. AU - Sulston, J. E. AU - Taylor, K. AU - Whitehead, S. AU - Barrell, B. G. PY - 1998 DA - 1998/06/01 TI - Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence JO - Nature SP - 537 EP - 544 VL - 393 IS - 6685 AB - Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation. SN - 1476-4687 UR - https://doi.org/10.1038/31159 DO - 10.1038/31159 ID - Cole1998 ER -