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TY - JOUR AU - Berridge, Michael J. AU - Irvine, Robin F. PY - 1984 DA - 1984/11/01 TI - Inositol trisphosphate, a novel second messenger in cellular signal transduction JO - Nature SP - 315 EP - 321 VL - 312 IS - 5992 AB - There has recently been rapid progress in understanding receptors that generate intracellular signals from inositol lipids. One of these lipids, phosphatidylinositol 4,5-bisphosphate, is hydrolysed to diacylglycerol and inositol trisphosphate as part of a signal transduction mechanism for controlling a variety of cellular processes including secretion, metabolism, phototransduction and cell proliferation. Diacylglycerol operates within the plane of the membrane to activate protein kinase C, whereas inositol trisphosphate is released into the cytoplasm to function as a second messenger for mobilizing intracellular calcium. SN - 1476-4687 UR - https://doi.org/10.1038/312315a0 DO - 10.1038/312315a0 ID - Berridge1984 ER -