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TY - JOUR AU - Sporn, Michael B. AU - Roberts, Anita B. PY - 1985 DA - 1985/02/01 TI - Autocrine growth factors and cancer JO - Nature SP - 745 EP - 747 VL - 313 IS - 6005 AB - The ability of cancer cells to produce and to respond to their own growth factors (autocrine secretion) has become a central concept linking oncogene and growth factor research. Oncogenes confer growth factor autonomy on cells not only by coding directly for autocrine peptide growth factors or their receptors, but also by amplifying the mitogenic signals generated by a growth factor at its receptor. Antagonists of positive autocrine growth factors can inhibit growth of cancer cells in experimental animals. Recently identified negative autocrine growth factors might themselves control aberrant cell growth. SN - 1476-4687 UR - https://doi.org/10.1038/313745a0 DO - 10.1038/313745a0 ID - Sporn1985 ER -