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TY - JOUR AU - Rupp, Fabio AU - Acha-Orbea, Hans AU - Hengartner, Hans AU - Zinkernagel, Rolf AU - Joho, Rolf PY - 1985 DA - 1985/05/01 TI - Identical Vβ T-cell receptor genes used in alloreactive cytotoxic and antigen plus I–A specific helper T cells JO - Nature SP - 425 EP - 427 VL - 315 IS - 6018 AB - T lymphocytes involved in the cellular immune response carry cell-surface receptors, responsible for antigen and self recognition. This T-cell receptor molecule is a heterodimeric protein consisting of disulphide-linked α- and β-chains with variable (V) and constant (C) regions1–5. Several complementary DNA and genomic DNA clones have been isolated and characterized6–12. These analyses showed that the genomic arrangement and rearrangement of T-cell receptor genes using VT, diversity (DT), joining (JT) and CT gene segments is very similar to the structure of the known immunoglobulin genes (see ref. 13 for review). We have isolated two cDNA clones from an allospecific cytotoxic T cell, one of which shows a productive Vβ–Jβ–Cβ 1 rearrangement without an intervening Dβ segment. This Vβ gene segment is identical to the Vβ gene expressed in a helper T-cell clone specific for chicken red blood cells and H–2Ib (ref. 14). The other clone carries the Cβ2 gene of the T-cell receptor, but the Cβ2 sequence is preceded by a DNA sequence that does not show any similarity to Vβ or Jβ sequences. SN - 1476-4687 UR - https://doi.org/10.1038/315425a0 DO - 10.1038/315425a0 ID - Rupp1985 ER -