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TY - JOUR AU - Kopito, Ron R. AU - Lodish, Harvey F. PY - 1985 DA - 1985/07/01 TI - Primary structure and transmembrane orientation of the murine anion exchange protein JO - Nature SP - 234 EP - 238 VL - 316 IS - 6025 AB - The amino-acid sequence of murine band 3, deduced from the nucleotide sequence of a complementary DNA clone, confirms that this integral membrane glycoprotein is composed of two major structural domains which correlate with its dual functions as the anchor for the erythrocyte cytoskeleton and as a plasma membrane anion antiporter. This latter activity resides within a highly Hydrophobie domain that crosses the plasma membrane at least 12 times. SN - 1476-4687 UR - https://doi.org/10.1038/316234a0 DO - 10.1038/316234a0 ID - Kopito1985 ER -