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TY - JOUR AU - Hirano, Toshio AU - Yasukawa, Kiyoshi AU - Harada, Hisashi AU - Taga, Tetsuya AU - Watanabe, Yasuo AU - Matsuda, Tadashi AU - Kashiwamura, Shin-ichiro AU - Nakajima, Koichi AU - Koyama, Koichi AU - Iwamatsu, Akihiro AU - Tsunasawa, Susumu AU - Sakiyama, Fumio AU - Matsui, Hiroshi AU - Takahara, Yoshiyuki AU - Taniguchi, Tadatsugu AU - Kishimoto, Tadamitsu PY - 1986 DA - 1986/11/01 TI - Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin JO - Nature SP - 73 EP - 76 VL - 324 IS - 6092 AB - When stimulated with antigen, B cells are influenced by T cells to proliferate and differentiate into antibody-forming cells. Since it was reported1,2 that soluble factors could replace certain functions of helper T cells in the antibody response, several different kinds of lymphokines and monokines have been reported in B-cell growth and differentiation3,4. Among these, human B-cell differentiation factor (BCDF or BSF-2) has been shown to induce the final maturation of B cells into immunoglobulin-secreting cells5–8. BSF-2 was purified to homogeneity9 and its partial NH2-terminal amino-acid sequence was determined10. These studies indicated that BSF-2 is functionally and structurally unlike other known proteins. Here, we report the molecular cloning, structural analysis and functional expression of the cDNA encoding human BSF-2. The primary sequence of BSF-2 deduced from the cDNA reveals that BSF-2 is a novel interleukin consisting of 184 amino acids. SN - 1476-4687 UR - https://doi.org/10.1038/324073a0 DO - 10.1038/324073a0 ID - Hirano1986 ER -