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TY - JOUR AU - Vinson, Charles R. AU - Adler, Paul N. PY - 1987 DA - 1987/10/01 TI - Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila JO - Nature SP - 549 EP - 551 VL - 329 IS - 6139 AB - The function of the frizzled (fz) locus is required for the development of a parallel array of bristles and hairs on the adult cuticle of Drosophila melanogaster1,2. Marked fz mitotic clones from five alleles were generated and examined in the wing. Three alleles have a non-cell-autonomous hair polarity phenotype; wild-type cells distal to fz clones produce hairs that have an abnormal polarity. In contrast, fz clones of the other two fz alleles examined do not disrupt the polarity of neighbouring cells. These data suggest that fz has two mutably separate functions in establishing hair polarity on the wing. One function involves the transmittance and/or generation of a polarity signal along the proximal-distal axis of the wing. The second function involves the cellular interpretation of a polarity signal. SN - 1476-4687 UR - https://doi.org/10.1038/329549a0 DO - 10.1038/329549a0 ID - Vinson1987 ER -