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TY - JOUR AU - Kothary, R. AU - Clapoff, S. AU - Brown, A. AU - Campbell, R. AU - Peterson, A. AU - Rossant, J. PY - 1988 DA - 1988/09/01 TI - A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube JO - Nature SP - 435 EP - 437 VL - 335 IS - 6189 AB - The site of integration of transgenes in the host genome can affect levels of expression1 and occasionally confer ectopic patterns of expression on otherwise tissue-specific genes2. We describe here a line of mice in which an hsp68-lacZ transgene is expressed in unstressed developing neural tissue and where the transgene insertion has caused a mutation of a neural tissue-specific gene, dystonia musculorum (dt). This coincidence suggests that expression of the hsp68-lacZ construct may be controlled directly by cis-acting regulatory sequences that normally control the developmental expression of the dt gene. Such constructs may serve as useful tools for identifying new tissue-specific enhancers and their associated genes3,4. SN - 1476-4687 UR - https://doi.org/10.1038/335435a0 DO - 10.1038/335435a0 ID - Kothary1988 ER -