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TY - JOUR AU - Loetscher, Pius AU - Uguccioni, Mariagrazia AU - Bordoli, Lorenza AU - Baggiolini, Marco AU - Moser, Bernhard AU - Chizzolini, Carlo AU - Dayer, Jean-Michel PY - 1998 DA - 1998/01/01 TI - CCR5 is characteristic of Th1 lymphocytes JO - Nature SP - 344 EP - 345 VL - 391 IS - 6665 AB - CD4+ lymphocytes can be assigned to two subsets1. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites. Th2 lymphocytes preferentially express the chemokine receptor CCR3 (23). We have studied the occurrence of two additional chemokine receptors, CCR5 and CXCR3, in human, antigen-specific CD4+ Th1 and Th2 cell clones4. SN - 1476-4687 UR - https://doi.org/10.1038/34814 DO - 10.1038/34814 ID - Loetscher1998 ER -