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TY - JOUR AU - Spies, Thomas AU - Bresnahan, Maureen AU - Bahrain, Seiamak AU - Arnold, Daniele AU - Blanck, George AU - Mellins, Elizabeth AU - Pious, Donald AU - DeMars, Robert PY - 1990 DA - 1990/12/01 TI - A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway JO - Nature SP - 744 EP - 747 VL - 348 IS - 6303 AB - MAJOR histocompatibility complex (MHC) class I molecules export peptides to the cell surface for surveillance by cytotoxic T lymphocytes1-3. Intracellular peptide binding is critical for the proper assembly and transport of class I molecules4–6. This mechanism is impaired as a result of a non-functional peptide supply factor gene (PSF) in several human mutant cell lines with genomic lesions in the MHC. We have now identified PSF in the MHC class II region by deletion mapping in mutants and chromosome-walking. PSF is homologous to mammalian and bacterial ATP-dependent transport proteins, suggesting that it operates in the intracellular transport of peptides. SN - 1476-4687 UR - https://doi.org/10.1038/348744a0 DO - 10.1038/348744a0 ID - Spies1990 ER -