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TY - JOUR AU - Glotzer, Michael AU - Murray, Andrew W. AU - Kirschner, Marc W. PY - 1991 DA - 1991/01/01 TI - Cyclin is degraded by the ubiquitin pathway JO - Nature SP - 132 EP - 138 VL - 349 IS - 6305 AB - Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a hybrid protein susceptible to proteolysis at mitosis. During the course of degradation, both cyclin and the hybrid form conjugates with ubiquitin. The kinetic properties of the conjugates indicate that cyclin is degraded by ubiquitin-dependent proteolysis. Thus anaphase may be triggered by the recognition of cyclin by the ubiquitin-conjugating system. SN - 1476-4687 UR - https://doi.org/10.1038/349132a0 DO - 10.1038/349132a0 ID - Glotzer1991 ER -