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TY - JOUR AU - Krek, Wilhelm PY - 2000 DA - 2000/07/01 TI - VHL takes HIF’s breath away JO - Nature Cell Biology SP - E121 EP - E123 VL - 2 IS - 7 AB - Inactivation of the von Hippel–Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel–Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the α-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination. SN - 1476-4679 UR - https://doi.org/10.1038/35017129 DO - 10.1038/35017129 ID - Krek2000 ER -