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TY - JOUR AU - The Arabidopsis Genome Initiative PY - 2000 DA - 2000/12/01 TI - Analysis of the genome sequence of the flowering plant Arabidopsis thaliana JO - Nature SP - 796 EP - 815 VL - 408 IS - 6814 AB - The flowering plant Arabidopsis thaliana is an important model system for identifying genes and determining their functions. Here we report the analysis of the genomic sequence of Arabidopsis. The sequenced regions cover 115.4 megabases of the 125-megabase genome and extend into centromeric regions. The evolution of Arabidopsis involved a whole-genome duplication, followed by subsequent gene loss and extensive local gene duplications, giving rise to a dynamic genome enriched by lateral gene transfer from a cyanobacterial-like ancestor of the plastid. The genome contains 25,498 genes encoding proteins from 11,000 families, similar to the functional diversity of Drosophila and Caenorhabditis elegans— the other sequenced multicellular eukaryotes. Arabidopsis has many families of new proteins but also lacks several common protein families, indicating that the sets of common proteins have undergone differential expansion and contraction in the three multicellular eukaryotes. This is the first complete genome sequence of a plant and provides the foundations for more comprehensive comparison of conserved processes in all eukaryotes, identifying a wide range of plant-specific gene functions and establishing rapid systematic ways to identify genes for crop improvement. SN - 1476-4687 UR - https://doi.org/10.1038/35048692 DO - 10.1038/35048692 ID - The Arabidopsis Genome Initiative2000 ER -