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TY - JOUR AU - Grimm, Jeffrey W. AU - Hope, Bruce T. AU - Wise, Roy A. AU - Shaham, Yavin PY - 2001 DA - 2001/07/01 TI - Incubation of cocaine craving after withdrawal JO - Nature SP - 141 EP - 142 VL - 412 IS - 6843 AB - Relapse to cocaine addiction is frequently associated with subjective reports of craving, a poorly understood state that precedes and accompanies cocaine-seeking behaviours1. It has been suggested2 that over the first few weeks of withdrawal from cocaine, human addicts become sensitized to drug-associated environmental cues that act as external stimuli for craving, although the evidence for this is inconsistent3. Here we provide behavioural evidence from laboratory animals suggesting that the onset of craving is delayed and that craving does not decay, but rather increases progressively, over a two-month withdrawal period. SN - 1476-4687 UR - https://doi.org/10.1038/35084134 DO - 10.1038/35084134 ID - Grimm2001 ER -